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Connexin 43 (GJA1) Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS628391

Gap junctions are composed of transmembrane channels that link the cytoplasm of neighboring cells. They differ from other membrane channels since they exist between two cells. Gap junctions are relatively non-specific and allow passive diffusion of small… More details

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Product Overview

Online Datasheet in PDF
Product Name
Connexin 43 (Gja1), Polyclonal Antibody
Full Product Name
Connexin 43 (Gap junction alpha-1 protein, Cx43, Connexin43, Connexin-43, Gap junction 43kD heart protein, GJA1)
Product Gene Name
anti-Gja1 antibody
Product Synonym Names
Anti -Connexin 43 (Gap junction alpha-1 protein, Cx43, Connexin43, Connexin-43, Gap junction 43kD heart protein, GJA1)
Clonality
Polyclonal
Isotype
IgG
Host
Goat
Species Reactivity
Rat
Form/Format
Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
Purity/Purification
Affinity Purified
Purified by affinity chromatography.
Specificity
Recognizes rat GJA1. Sequence Homology: human, canine, porcine.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
43,004 Da
Chromosome Location
Chromosome: 10; NC_000076.5 (56097106..56110225). Location: 10 B4; 10 29.0 cM
3D Structure
ModBase 3D Structure for P23242
Immunogen
Synthetic peptide corresponding to C-QPFDFPDDNQNSKK, from the internal region of rat GJA1(NP_000156.1).

Product Categories/Family for anti-Gja1 antibody

Antibodies; Abs to Connexin; Junction Proteins
Applications Tested/Suitable for anti-Gja1 antibody
Western Blot (WB)
Application Notes for anti-Gja1 antibody
Suitable for use in ELISA, Western Blot.
Dilution: ELISA: 1:64,000

Chemiluminescence of anti-Gja1 antibody

(0.3ug/ml) staining of Rat Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-GJA1 Polyclonal Antibody – Cat# MBS628391

Other Notes

Small volumes of anti-Gja1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Gja1 purchase

MBS628391 is an antibody targeting Gja1. Also known as Connexin 43 (Gap junction alpha-1 protein, Cx43, Connexin43, Connexin-43, Gap junction 43kD heart protein, GJA1). Reactive in Rat. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for Gja1. It may not necessarily be applicable to this product.

NCBI GI #
50510
NCBI GeneID
14609
UniProt Primary Accession #
P23242
UniProt Related Accession #
P23242; Q3UTR0; Q544I7; Q6T9D4; Q7TMQ1; Q8C4N2; Q8CE05; Q9CT20
NCBI Official Full Name
connexin 43
NCBI Official Synonym Full Names
gap junction protein, alpha 1
NCBI Official Symbol
Gja1
NCBI Official Synonym Symbols
Cx43; Npm1; Cnx43; Gja-1; AU042049; AW546267; Cx43alpha1; connexin43
UniProt Protein Name
Gap junction alpha-1 protein
UniProt Synonym Protein Names
Connexin-43; Cx43; Gap junction 43 kDa heart protein
Protein Family
Gap junction alpha-1 protein
UniProt Gene Name
Gja1
UniProt Synonym Gene Names
Cxn-43
UniProt Entry Name
CXA1_MOUSE
NCBI Protein Information
gap junction alpha-1 protein; connexin 43; connexin-43; alpha 1 connexin; gap junction 43 kDa heart protein; gap junction membrane channel protein alpha 1

UniProt Comments for Gja1

GJA1: an integral membrane protein of the connexin family, alpha-type (group II) subfamily. Hexamers of connexin-43 form connexons, which aggregate together to form gap junctions, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Channel, misc.; Membrane protein, multi-pass

Cellular Component: Golgi apparatus; focal adhesion; contractile fiber; lysosome; early endosome; integral to membrane; intermediate filament; intercellular junction; fascia adherens; cytosol; lipid raft; multivesicular body; connexon complex; mitochondrial outer membrane; membrane; late endosome; apical plasma membrane; cytoplasm; plasma membrane; gap junction; cell junction; endosome; lateral plasma membrane

Molecular Function: protein domain specific binding; protein binding; signal transducer activity; ion transmembrane transporter activity; beta-tubulin binding; transmembrane transporter activity; SH3 domain binding; gap junction channel activity; PDZ domain binding; receptor binding

Biological Process: lens development in camera-type eye; apoptosis; heart development; neuron migration; milk ejection; positive regulation of vasodilation; signal transduction; regulation of heart contraction; negative regulation of cell proliferation; elevation of cytosolic calcium ion concentration; cell-cell signaling; negative regulation of cardiac muscle cell proliferation; positive regulation of glomerular filtration; positive regulation of striated muscle development; cell communication; heart looping; transmembrane transport; adult heart development; ATP transport; intercellular junction assembly and maintenance; chronic inflammatory response; positive regulation of I-kappaB kinase/NF-kappaB cascade; epithelial cell maturation; in utero embryonic development; regulation of bone remodeling; positive regulation of insulin secretion; skeletal muscle regeneration; regulation of calcium ion transport; vascular transport; protein oligomerization; osteoblast differentiation; positive regulation of osteoblast differentiation; negative regulation of endothelial cell proliferation; positive regulation of protein catabolic process; positive regulation of vasoconstriction; blood vessel morphogenesis; embryonic heart tube development; embryonic digit morphogenesis; regulation of bone mineralization; neurite morphogenesis; response to pH
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Research Articles on Gja1

1. While Cx43 G60S/+ mutant mice had severe atrial tachycardia/fibrillation, Cx40-/- mice were resistant to carbachol-induced atrial tachycardia/fibrillation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Gja1 antibody

 Products by Pathway  Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Formation Of Annular Gap Junctions Pathway antibodies  Formation Of Annular Gap Junctions Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram
 Gap Junction Assembly Pathway antibodies  Gap Junction Assembly Pathway Diagram
 Gap Junction Degradation Pathway antibodies  Gap Junction Degradation Pathway Diagram
 Gap Junction Trafficking Pathway antibodies  Gap Junction Trafficking Pathway Diagram

Diseases associated with anti-Gja1 antibody

 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >51 publications with Gja1 and Congenital Abnormalities
 OCULODENTODIGITAL DYSPLASIA Antibodies  >40 publications with Gja1 and OCULODENTODIGITAL DYSPLASIA
 Cardiovascular Diseases Antibodies  >36 publications with Gja1 and Cardiovascular Diseases
 Eye Abnormalities Antibodies  >32 publications with Gja1 and Eye Abnormalities
 Heart Diseases Antibodies  >31 publications with Gja1 and Heart Diseases
 Limb Deformities, Congenital Antibodies  >31 publications with Gja1 and Limb Deformities, Congenital
 Neoplasms Antibodies  >26 publications with Gja1 and Neoplasms
 Craniofacial Abnormalities Antibodies  >20 publications with Gja1 and Craniofacial Abnormalities
 Arrhythmias, Cardiac Antibodies  >18 publications with Gja1 and Arrhythmias, Cardiac
 Skin Diseases Antibodies  >14 publications with Gja1 and Skin Diseases

Organs/Tissues associated with anti-Gja1 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >48 publications with Gja1 and Muscle
 Heart Antibodies  >46 publications with Gja1 and Heart
 Eye Antibodies  >45 publications with Gja1 and Eye
 Bone Antibodies  >24 publications with Gja1 and Bone
 Brain Antibodies  >19 publications with Gja1 and Brain
 Skin Antibodies  >15 publications with Gja1 and Skin
 Ovary Antibodies  >15 publications with Gja1 and Ovary
 Lung Antibodies  >10 publications with Gja1 and Lung
 Embryonic Tissue Antibodies  >9 publications with Gja1 and Embryonic Tissue
 Testis Antibodies  >8 publications with Gja1 and Testis
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