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ECGF1 (TYMP) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS628475

ECGF1 is an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in the gene encoding ECGF1… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
ECGF1 (TYMP), Polyclonal Antibody
Full Product Name
ECGF1, ID (Thymidine Phosphorylase, TdRPase, TP, Platelet-derived Endothelial Cell Growth Factor, PD-ECGF, Gliostatin, TYMP)
Product Gene Name
anti-TYMP antibody
Product Synonym Names
Anti -ECGF1, ID (Thymidine Phosphorylase, TdRPase, TP, Platelet-derived Endothelial Cell Growth Factor, PD-ECGF, Gliostatin, TYMP)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human ECGF1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
49,955 Da
Chromosome Location
Chromosome: 22; NC_000022.10 (50964181..50968514, complement). Location: 22q13.33
OMIM
131222
3D Structure
ModBase 3D Structure for P19971
Immunogen
Synthetic peptide at the Center of human ECGF1 (KLH).

Product Categories/Family for anti-TYMP antibody

Antibodies; Abs to Enzymes; Phosphorylase
Applications Tested/Suitable for anti-TYMP antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-TYMP antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100
Immunohistochemistry: 1:10-1:50

Western Blot (WB) of anti-TYMP antibody

Western blot analysis of anti-ECGF1(Center) Pab in HepG2 cell line lysates (35ug/lane). ECGF1(arrow) was detected using the purified Pab.
Rabbit Anti-TYMP Polyclonal Antibody – Cat# MBS628475

Immunohistochemistry (IHC) of anti-TYMP antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with ECGF1 antibody (Center) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-TYMP Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS628475

Other Notes

Small volumes of anti-TYMP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TYMP purchase

MBS628475 is an antibody targeting TYMP. Also known as ECGF1, ID (Thymidine Phosphorylase, TdRPase, TP, Platelet-derived Endothelial Cell Growth Factor, PD-ECGF, Gliostatin, TYMP). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TYMP. It may not necessarily be applicable to this product.

NCBI GI #
189701
NCBI GeneID
1890
NCBI Accession #
AAA60043.1
UniProt Primary Accession #
P19971
UniProt Secondary Accession #
Q13390; Q8WVB7; A8MW15; H9KVA0
UniProt Related Accession #
P19971
NCBI Official Full Name
endothelial cell growth factor
NCBI Official Synonym Full Names
thymidine phosphorylase
NCBI Official Symbol
TYMP
NCBI Official Synonym Symbols
TP; ECGF; ECGF1; MNGIE; MEDPS1; MTDPS1; PDECGF; hPD-ECGF
UniProt Protein Name
Thymidine phosphorylase
UniProt Synonym Protein Names
Gliostatin; Platelet-derived endothelial cell growth factor; PD-ECGF; TdRPase
UniProt Gene Name
TYMP
UniProt Synonym Gene Names
ECGF1; TP; PD-ECGF
UniProt Entry Name
TYPH_HUMAN
NCBI Protein Information
thymidine phosphorylase; tdRPase; gliostatin

NCBI Summary for TYMP

This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in this gene have been associated with mitochondrial neurogastrointestinal encephalomyopathy. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2012]
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UniProt Comments for TYMP

ECGF1: May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. Homodimer. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.

Protein type: Cytokine; DNA replication; Transferase; Nucleotide Metabolism - pyrimidine; EC 2.4.2.4; Motility/polarity/chemotaxis; Xenobiotic Metabolism - drug metabolism - other enzymes; Phosphorylase

Chromosomal Location of Human Ortholog: 22q13.33

Cellular Component: cytosol

Molecular Function: thymidine phosphorylase activity; growth factor activity; phosphorylase activity; transferase activity, transferring pentosyl groups; pyrimidine-nucleoside phosphorylase activity; platelet-derived growth factor receptor binding

Biological Process: mitochondrial genome maintenance; pyrimidine nucleoside catabolic process; pyrimidine base metabolic process; nucleobase, nucleoside and nucleotide metabolic process; pyrimidine nucleotide metabolic process; pyrimidine nucleoside salvage; angiogenesis; chemotaxis; DNA replication; cell differentiation

Disease: Mitochondrial Dna Depletion Syndrome 1 (mngie Type)
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Research Articles on TYMP

1. These findings suggest that thymidine phosphorylase plays an important role in angiogenesis, extracellular matrix remodeling and in the prognosis of patients with colorectal cancer

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TYMP antibody

 Reference Product  PubMed Publications
 TYMS antibody  >4 publications with TYMP and TYMS
 DPYD antibody  >3 publications with TYMP and DPYD
 UPP1 antibody  >2 publications with TYMP and UPP1

Pathways associated with anti-TYMP antibody

 Products by Pathway  Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
 Fluoropyrimidine Activity Pathway antibodies  Fluoropyrimidine Activity Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Pyrimidine Catabolism Pathway antibodies  Pyrimidine Catabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram

Diseases associated with anti-TYMP antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >21 publications with TYMP and Nervous System Diseases
 Brain Diseases Antibodies  >20 publications with TYMP and Brain Diseases
 Neoplasms Antibodies  >20 publications with TYMP and Neoplasms
 Carcinoma Antibodies  >7 publications with TYMP and Carcinoma
 Colorectal Neoplasms Antibodies  >7 publications with TYMP and Colorectal Neoplasms
 Mitochondrial neurogastrointestinal encephalopathy syndrome Antibodies  >6 publications with TYMP and Mitochondrial neurogastrointestinal encephalopathy syndrome
 Adenocarcinoma Antibodies  >5 publications with TYMP and Adenocarcinoma
 Diarrhea Antibodies  >4 publications with TYMP and Diarrhea
 Vomiting Antibodies  >4 publications with TYMP and Vomiting
 Pain Antibodies  >3 publications with TYMP and Pain

Organs/Tissues associated with anti-TYMP antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >17 publications with TYMP and Muscle
 Blood Antibodies  >12 publications with TYMP and Blood
 Liver Antibodies  >9 publications with TYMP and Liver
 Brain Antibodies  >9 publications with TYMP and Brain
 Skin Antibodies  >4 publications with TYMP and Skin
 Nerve Antibodies  >4 publications with TYMP and Nerve
 Intestine Antibodies  >2 publications with TYMP and Intestine
 Lung Antibodies  >2 publications with TYMP and Lung
 Heart Antibodies  >2 publications with TYMP and Heart
 Eye Antibodies  >2 publications with TYMP and Eye
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