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KRT14 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS628483

KRT14 is a member of the keratin family, the most diverse group of intermediate filaments. This protein, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial… More details

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Product Overview

Online Datasheet in PDF
Product Name
KRT14, Polyclonal Antibody
Full Product Name
KRT14, ID (Keratin, Type I Cytoskeletal 14, Cytokeratin-14, CK-14, Keratin-14, K14)
Product Gene Name
anti-KRT14 antibody
Product Synonym Names
Anti -KRT14, ID (Keratin, Type I Cytoskeletal 14, Cytokeratin-14, CK-14, Keratin-14, K14)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human KRT14.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
51,561 Da
Chromosome Location
Chromosome: 17; NC_000017.10 (39738531..39743147, complement). Location: 17q12-q21
OMIM
125595
3D Structure
ModBase 3D Structure for P02533
Immunogen
Synthetic peptide selected from the Center region of human KRT14 (KLH).

Product Categories/Family for anti-KRT14 antibody

Antibodies; Abs to Keratin; Cytokeratin
Applications Tested/Suitable for anti-KRT14 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-KRT14 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100

Western Blot (WB) of anti-KRT14 antibody

Western blot analysis of KRT14 antibody (Center) in mouse NIH-3T3 cell line lysates (35ug/lane). KRT14 (arrow) was detected using the purified Pab.
Rabbit Anti-KRT14 Polyclonal Antibody – Cat# MBS628483

Immunohistochemistry (IHC) of anti-KRT14 antibody

Formalin-fixed and paraffin-embedded human breast carcinoma with KRT14 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-KRT14 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS628483

Flow Cytometry (FC/FACS) of anti-KRT14 antibody

KRT14 Antibody (Center) flow cytometry analysis of MDA-MB231 cells (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-KRT14 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS628483

Other Notes

Small volumes of anti-KRT14 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KRT14 purchase

MBS628483 is an antibody targeting KRT14. Also known as KRT14, ID (Keratin, Type I Cytoskeletal 14, Cytokeratin-14, CK-14, Keratin-14, K14). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for KRT14. It may not necessarily be applicable to this product.

NCBI GI #
15431310
NCBI GeneID
3861
NCBI Accession #
NP_000517.2
UniProt Primary Accession #
P02533
UniProt Secondary Accession #
Q14715; Q53XY3; Q9BUE3; Q9UBN2; Q9UBN3; Q9UCY4
UniProt Related Accession #
P02533; Q13092
GenBank Nucleotide #
NM_000526.4
NCBI Official Full Name
keratin, type I cytoskeletal 14
NCBI Official Synonym Full Names
keratin 14
NCBI Official Symbol
KRT14
NCBI Official Synonym Symbols
K14; NFJ; CK14; EBS3; EBS4
UniProt Protein Name
Keratin, type I cytoskeletal 14
UniProt Synonym Protein Names
Cytokeratin-14; CK-14; Keratin-14
Protein Family
Keratin
UniProt Gene Name
KRT14
UniProt Entry Name
K1C14_HUMAN
NCBI Protein Information
keratin, type I cytoskeletal 14; CK-14; keratin-14; cytokeratin 14; cytokeratin-14; OTTHUMP00000164624; keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner)

NCBI Summary for KRT14

This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11. [provided by RefSeq]
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UniProt Comments for KRT14

K14: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K5.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 17q21.2

Cellular Component: cytoplasm; keratin filament; intermediate filament; cytosol; nucleus

Molecular Function: protein binding; structural constituent of cytoskeleton

Biological Process: hemidesmosome assembly; epidermis development; epithelial cell differentiation; response to zinc ion; response to ionizing radiation; intermediate filament bundle assembly; aging; hair cycle

Disease: Epidermolysis Bullosa Simplex, Localized; Epidermolysis Bullosa Simplex, Generalized; Dermatopathia Pigmentosa Reticularis; Epidermolysis Bullosa Simplex, Autosomal Recessive 1; Naegeli Syndrome; Epidermolysis Bullosa Simplex, Dowling-meara Type
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Research Articles on KRT14

1. heterozygous G to A transition was found at nucleotide postion 1231 in exon 6 of KRT14 in family with epidermolysis bullosa simplex, generalized

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KRT14 antibody

 Reference Product  PubMed Publications
 KRT5 antibody  >57 publications with KRT14 and KRT5
 DST antibody  >2 publications with KRT14 and DST
 TRADD antibody  >1 publications with KRT14 and TRADD

Pathways associated with anti-KRT14 antibody

 Products by Pathway  Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram

Diseases associated with anti-KRT14 antibody

 Disease Name  Pubmed Publications
 Skin Diseases Antibodies  >122 publications with KRT14 and Skin Diseases
 Congenital Abnormalities Antibodies  >74 publications with KRT14 and Congenital Abnormalities
 Epidermolysis bullosa simplex, Koebner type Antibodies  >72 publications with KRT14 and Epidermolysis bullosa simplex, Koebner type
 Epidermolysis bullosa simplex, Cockayne-Touraine type Antibodies  >72 publications with KRT14 and Epidermolysis bullosa simplex, Cockayne-Touraine type
 Epidermolysis bullosa herpetiformis, Dowling-Meara Antibodies  >72 publications with KRT14 and Epidermolysis bullosa herpetiformis, Dowling-Meara
 Neoplasms Antibodies  >70 publications with KRT14 and Neoplasms
 Carcinoma Antibodies  >49 publications with KRT14 and Carcinoma
 Carcinoma, Squamous Cell Antibodies  >30 publications with KRT14 and Carcinoma, Squamous Cell
 Adenocarcinoma Antibodies  >17 publications with KRT14 and Adenocarcinoma
 Skin Neoplasms Antibodies  >16 publications with KRT14 and Skin Neoplasms

Organs/Tissues associated with anti-KRT14 antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >125 publications with KRT14 and Skin
 Blood Antibodies  >21 publications with KRT14 and Blood
 Mouth Antibodies  >12 publications with KRT14 and Mouth
 Esophagus Antibodies  >8 publications with KRT14 and Esophagus
 Lung Antibodies  >7 publications with KRT14 and Lung
 Mammary Gland Antibodies  >6 publications with KRT14 and Mammary Gland
 Liver Antibodies  >6 publications with KRT14 and Liver
 Connective Tissue Antibodies  >5 publications with KRT14 and Connective Tissue
 Cervix Antibodies  >5 publications with KRT14 and Cervix
 Thymus Antibodies  >4 publications with KRT14 and Thymus
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