Goat Anti-UBR2 Polyclonal Antibody – Cat# MBS628509

Ubiquitin Protein Ligase E3 Component N-Recognin 2 (UBR2) Antibody – Goat Polyclonal

Name: UBR2 Antibody; Polyclonal; Goat; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS628509
Price: 835 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS628509

This gene encodes an E3 ubiquitin ligase of the N-end rule proteolytic pathway that targets proteins with destabilizing N-terminal residues for polyubiquitylation and proteasome-mediated degradation. Alternative splicing results in multiple transcript… More details

$835 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

UBR2, Ubiquitin Protein Ligase E3 Component n-recognin 2, Polyclonal Antibody

Full Product Name

UBR2, Ubiquitin Protein Ligase E3 Component n-recognin 2

Product Gene Name

anti-UBR2 antibody

Product Synonym Names

Anti -UBR2, Ubiquitin Protein Ligase E3 Component n-recognin 2

Clonality

Polyclonal

Isotype

IgG

Host

Goat

Species Reactivity

Human

Form/Format

Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.

Purity/Purification

Affinity Purified
Purified by peptide affinity chromatography.

Specificity

Recognizes UBR2. Species sequence homology: human, mouse, bovine, canine.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

200,538 Da

Chromosome Location

Chromosome: 6; NC_000006.11 (42531760..42661243). Location: 6p21.1

OMIM

609134

3D Structure

ModBase 3D Structure for Q8IWV8

Immunogen

Synthetic peptide corresponding to SCPKSGGDKSRAPT, from the internal region of human UBR2 (NP_056070.1).

Product Categories/Family for anti-UBR2 antibody

Antibodies; Abs to Ubiquitin Ligases

Applications Tested/Suitable for anti-UBR2 antibody

ELISA (EL/EIA)

Application Notes for anti-UBR2 antibody

Suitable for use in ELISA.
Dilution: Peptide ELISA Titer: 1:32,000

Other Notes

Small volumes of anti-UBR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for UBR2 purchase

MBS628509 is an antibody targeting UBR2. Also known as UBR2, Ubiquitin Protein Ligase E3 Component n-recognin 2. Reactive in Human. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for UBR2. It may not necessarily be applicable to this product.

NCBI GI #

66347360

NCBI GeneID

23304

UniProt Primary Accession #

Q8IWV8

UniProt Secondary Accession #

O15057; Q4VXK2; Q5TFH6; Q6P2I2; Q6ZUD0

UniProt Related Accession #

Q8IWV8

NCBI Official Full Name

ubiquitin protein ligase E3 component n-recognin 2

NCBI Official Synonym Full Names

ubiquitin protein ligase E3 component n-recognin 2

NCBI Official Symbol

UBR2

NCBI Official Synonym Symbols

C6orf133; FLJ36357; KIAA0349; MGC71112; bA49A4.1; dJ242G1.1; dJ392M17.3; RP3-392M17.3; DKFZp686C08114

UniProt Protein Name

E3 ubiquitin-protein ligase UBR2

UniProt Synonym Protein Names

N-recognin-2; Ubiquitin-protein ligase E3-alpha-2; Ubiquitin-protein ligase E3-alpha-II

Protein Family

E3 ubiquitin-protein ligase

UniProt Gene Name

UBR2

UniProt Synonym Gene Names

C6orf133; KIAA0349

UniProt Entry Name

UBR2_HUMAN

NCBI Protein Information

E3 ubiquitin-protein ligase UBR2; OTTHUMP00000016403; OTTHUMP00000016405; OTTHUMP00000070741; ubiquitin-protein ligase E3-alpha-2; ubiquitin-protein ligase E3-alpha-II

UniProt Comments for UBR2

UBR2: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. Belongs to the UBR1 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; Ubiquitin ligase; Ligase; Ubiquitin conjugating system; EC 6.3.2.19

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: nucleoplasm; plasma membrane; chromatin; ubiquitin ligase complex

Molecular Function: protein binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activity

Biological Process: ubiquitin-dependent protein catabolic process; negative regulation of TOR signaling pathway; male meiosis I; chromatin silencing; spermatogenesis; histone H2A ubiquitination

Research Articles on UBR2

1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-UBR2 antibody

Reference Product	PubMed Publications
UBE2B antibody	>2 publications with UBR2 and UBE2B

Pathways associated with anti-UBR2 antibody

Products by Pathway	Pathway Diagram
Adaptive Immunity Signaling Pathway antibodies	Adaptive Immunity Signaling Pathway Diagram
Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies	Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies	Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram

Diseases associated with anti-UBR2 antibody

Disease Name	Pubmed Publications
Congenital Abnormalities Antibodies	>2 publications with UBR2 and Congenital Abnormalities
Carcinoma Antibodies	>1 publications with UBR2 and Carcinoma
Nervous System Malformations Antibodies	>1 publications with UBR2 and Nervous System Malformations

Organs/Tissues associated with anti-UBR2 antibody

Organ/Tissue Name	Pubmed Publications
Testis Antibodies	>3 publications with UBR2 and Testis
Heart Antibodies	>2 publications with UBR2 and Heart
Muscle Antibodies	>2 publications with UBR2 and Muscle
Pancreas Antibodies	>1 publications with UBR2 and Pancreas
Skin Antibodies	>1 publications with UBR2 and Skin
Bone Antibodies	>1 publications with UBR2 and Bone
Blood Antibodies	>1 publications with UBR2 and Blood
Uncharacterized Tissue Antibodies	>1 publications with UBR2 and Uncharacterized Tissue