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SRSF5 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS628550

SFRS5 plays a role in constitutive splicing and can modulate the selection of alternative splice sites. More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
SFRS5 (SRSF5), Polyclonal Antibody
Full Product Name
SFRS5, ID (Y85) (Splicing Factor, Arginine/Serine-rich 5, Pre-mRNA-splicing Factor SRP40, Delayed-early Protein HRS, SRP40, HRS)
Product Gene Name
anti-SRSF5 antibody
Product Synonym Names
Anti -SFRS5, ID (Y85) (Splicing Factor, Arginine/Serine-rich 5, Pre-mRNA-splicing Factor SRP40, Delayed-early Protein HRS, SRP40, HRS)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human SFRS5.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
31,264 Da
Chromosome Location
Chromosome: 14; NC_000014.8 (70233812..70238722). Location: 14q24
OMIM
600914
3D Structure
ModBase 3D Structure for Q13243
Immunogen
Synthetic peptide selected from the Center region of human SFRS5 (KLH).

Product Categories/Family for anti-SRSF5 antibody

Antibodies; Abs to Splicing Factors
Applications Tested/Suitable for anti-SRSF5 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-SRSF5 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100

Western Blot (WB) of anti-SRSF5 antibody

Western blot analysis of SFRS5 antibody (Center Y85) in NCI-H460 cell line lysates (35ug/lane). SFRS5 (arrow) was detected using the purified Pab.
Rabbit Anti-SRSF5 Polyclonal Antibody – Cat# MBS628550

Flow Cytometry (FC/FACS) of anti-SRSF5 antibody

SFRS5 Antibody (Center Y85) flow cytometric analysis of NCI-H292 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-SRSF5 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS628550

Other Notes

Small volumes of anti-SRSF5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SRSF5 purchase

MBS628550 is an antibody targeting SRSF5. Also known as SFRS5, ID (Y85) (Splicing Factor, Arginine/Serine-rich 5, Pre-mRNA-splicing Factor SRP40, Delayed-early Protein HRS, SRP40, HRS). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SRSF5. It may not necessarily be applicable to this product.

NCBI GI #
86991440
NCBI GeneID
6430
NCBI Accession #
NP_008856.2
UniProt Primary Accession #
Q13243
UniProt Secondary Accession #
O14797; Q16662; Q49AD6; Q6FGE0
UniProt Related Accession #
Q13243
GenBank Nucleotide #
NM_006925.3
NCBI Official Full Name
serine/arginine-rich splicing factor 5
NCBI Official Synonym Full Names
serine/arginine-rich splicing factor 5
NCBI Official Symbol
SRSF5
NCBI Official Synonym Symbols
HRS; SFRS5; SRP40
UniProt Protein Name
Serine/arginine-rich splicing factor 5
UniProt Synonym Protein Names
Delayed-early protein HRS; Pre-mRNA-splicing factor SRP40; Splicing factor, arginine/serine-rich 5
Protein Family
Serine/arginine-rich splicing factor
UniProt Gene Name
SRSF5
UniProt Synonym Gene Names
HRS; SFRS5; SRP40
UniProt Entry Name
SRSF5_HUMAN
NCBI Protein Information
serine/arginine-rich splicing factor 5; SR splicing factor 5; delayed-early protein HRS; pre-mRNA-splicing factor SRP40; splicing factor, arginine/serine-rich 5

NCBI Summary for SRSF5

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2010]
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UniProt Comments for SRSF5

SFRS5: Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Belongs to the splicing factor SR family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Spliceosome; RNA-binding; RNA processing

Chromosomal Location of Human Ortholog: 14q24

Cellular Component: nucleoplasm; cytoplasm; nucleolus; nuclear speck; nucleus

Molecular Function: protein binding; RS domain binding; nucleotide binding

Biological Process: nuclear mRNA splicing, via spliceosome; transcription from RNA polymerase II promoter; mRNA splice site selection; mRNA export from nucleus; regulation of cell cycle; RNA splicing; response to wounding; gene expression; mRNA 3'-end processing; mRNA processing; termination of RNA polymerase II transcription
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Research Articles on SRSF5

1. We show that changes in alternative splicing of hnRNP A/B, affected by up regulation of SRSF5 (SRp40) or by treatment with C6-ceramide, occur within supraspliceosomes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SRSF5 antibody

 Products by Pathway  Pathway Diagram
 Cleavage Of Growing Transcript In The Termination Region Pathway antibodies  Cleavage Of Growing Transcript In The Termination Region Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Processing Of Capped Intron-Containing Pre-mRNA Pathway antibodies  Processing Of Capped Intron-Containing Pre-mRNA Pathway Diagram
 RNA Polymerase II Transcription Pathway antibodies  RNA Polymerase II Transcription Pathway Diagram
 RNA Polymerase II Transcription Termination Pathway antibodies  RNA Polymerase II Transcription Termination Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 Transport Of Mature Transcript To Cytoplasm Pathway antibodies  Transport Of Mature Transcript To Cytoplasm Pathway Diagram

Diseases associated with anti-SRSF5 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >2 publications with SRSF5 and Neoplasms
 Ovarian Neoplasms Antibodies  >1 publications with SRSF5 and Ovarian Neoplasms
 Breast Neoplasms Antibodies  >1 publications with SRSF5 and Breast Neoplasms
 Carcinoma Antibodies  >1 publications with SRSF5 and Carcinoma

Organs/Tissues associated with anti-SRSF5 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1 publications with SRSF5 and Blood
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