• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

AADAC Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS628566

Arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens. More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
AADAC, Polyclonal Antibody
Full Product Name
AADAC, CT (Arylacetamide Deacetylase, DAC)
Product Gene Name
anti-AADAC antibody
Product Synonym Names
Anti -AADAC, CT (Arylacetamide Deacetylase, DAC)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.52% sodium azide.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human AADAC.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
45,734 Da
Chromosome Location
Chromosome: 3; NC_000003.11 (151531861..151546276). Location: 3q21.3-q25.2
OMIM
600338
3D Structure
ModBase 3D Structure for P22760
Immunogen
KLH-conjugated synthetic peptide corresponding to a portion of amino acids within residues 279-309 in the C-terminal region of human AADAC.

Product Categories/Family for anti-AADAC antibody

Antibodies; Abs to Enzymes
Applications Tested/Suitable for anti-AADAC antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-AADAC antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100

Western Blot (WB) of anti-AADAC antibody

Western blot analysis of AADAC Antibody (C-term) in 293 cell line lysates (35ug/lane). AADAC (arrow) was detected using the purified Pab.
Rabbit Anti-AADAC Polyclonal Antibody – Cat# MBS628566

Immunohistochemistry (IHC) of anti-AADAC antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma with AADAC Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-AADAC Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS628566

Flow Cytometry (FC/FACS) of anti-AADAC antibody

Flow cytometric analysis of widr cells using AADAC Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-AADAC Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS628566

Western Blot (WB) of anti-AADAC antibody

Western blot analysis of AADAC (arrow) using rabbit polyclonal AADAC Antibody (C-term) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the AADAC gene.
Rabbit Anti-AADAC Polyclonal Antibody, Western Blot (WB) – Cat# MBS628566

Other Notes

Small volumes of anti-AADAC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AADAC purchase

MBS628566 is an antibody targeting AADAC. Also known as AADAC, CT (Arylacetamide Deacetylase, DAC). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for AADAC. It may not necessarily be applicable to this product.

NCBI GI #
68299767
NCBI GeneID
13
NCBI Accession #
NP_001077.2
UniProt Primary Accession #
P22760
UniProt Secondary Accession #
Q8N1A9; A8K3L3; D3DNJ6
UniProt Related Accession #
P22760
GenBank Nucleotide #
NM_001086.2
NCBI Official Full Name
arylacetamide deacetylase
NCBI Official Synonym Full Names
arylacetamide deacetylase (esterase)
NCBI Official Symbol
AADAC
NCBI Official Synonym Symbols
DAC; CES5A1
UniProt Protein Name
Arylacetamide deacetylase
Protein Family
Arylacetamide deacetylase
UniProt Gene Name
AADAC
UniProt Synonym Gene Names
DAC
UniProt Entry Name
AAAD_HUMAN
NCBI Protein Information
arylacetamide deacetylase; OTTHUMP00000216826; OTTHUMP00000216827

NCBI Summary for AADAC

Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens [provided by RefSeq]

UniProt Comments for AADAC

AADAC: Arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens. Displays major serine hydrolase activity in liver microsomes. Hydrolyzes also flutamide, which is an antiandrogen drug used for the treatment of prostate cancer that occasionaly causes severe hepatotoxicity. Displays cellular triglyceride lipase activity in liver. Increases intracellular fatty acids derived from hydrolysis of newly formed triglyceride stores. Belongs to the 'GDXG' lipolytic enzyme family.

Protein type: Endoplasmic reticulum; Membrane protein, integral; Deacetylase; Motility/polarity/chemotaxis; EC 3.1.1.3; Lipase

Chromosomal Location of Human Ortholog: 3q25.1

Cellular Component: endoplasmic reticulum membrane; integral to membrane

Molecular Function: deacetylase activity; triacylglycerol lipase activity; serine hydrolase activity; lipase activity; catalytic activity

Biological Process: metabolic process
Show more

Research Articles on AADAC

1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-AADAC antibody

 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >1 publications with AADAC and Liver Diseases
 Neoplasms Antibodies  >1 publications with AADAC and Neoplasms
 Adenocarcinoma Antibodies  >1 publications with AADAC and Adenocarcinoma
 Carcinoma Antibodies  >1 publications with AADAC and Carcinoma
 Carcinoma, Hepatocellular Antibodies  >1 publications with AADAC and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >1 publications with AADAC and Liver Neoplasms
 Fatty Liver Antibodies  >1 publications with AADAC and Fatty Liver

Organs/Tissues associated with anti-AADAC antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >4 publications with AADAC and Liver
 Adipose Tissue Antibodies  >1 publications with AADAC and Adipose Tissue
 Connective Tissue Antibodies  >1 publications with AADAC and Connective Tissue
 Pancreas Antibodies  >1 publications with AADAC and Pancreas
 Adrenal Gland Antibodies  >1 publications with AADAC and Adrenal Gland
 Intestine Antibodies  >1 publications with AADAC and Intestine
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000