Rabbit Anti-CLCN2 Polyclonal Antibody – Cat# MBS6286354

CLCN2 Antibody – Rabbit Polyclonal

Name: CLCN2 Antibody; Polyclonal; Rabbit; Human/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6286354
Price: 1025 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6286354

The transmembrane protein encoded by this gene is a voltage-gated chloride channel that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Four transcript variants encoding different isoforms have… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CLCN2, Polyclonal Antibody

Full Product Name

CLCN2, NT (CLCN2, Chloride channel protein 2) (MaxLight 405)

Product Gene Name

anti-CLCN2 antibody

Product Synonym Names

CLCN2; Chloride channel protein 2

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight405.

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight405 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

OMIM

phenotype 615651

3D Structure

ModBase 3D Structure for P51788

Immunogen

CLCN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 208-237 amino acids from the N-terminal region of human CLCN2.

Conjugate

MaxLight405

Note

Preservative Free

Product Categories/Family for anti-CLCN2 antibody

Antibodies; Ion Channel

Applications Tested/Suitable for anti-CLCN2 antibody

Western Blot (WB), FLISA

Application Notes for anti-CLCN2 antibody

WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-CLCN2 antibody

Scheper, G.C., et al. Genet Test Mol Biomarkers 14(2):255-257(2010). Cornejo, I., et al. J. Cell. Physiol. 221(3):650-657(2009). Thompson, C.H., et al. J. Biol. Chem. 284(38):26051-26062(2009). Kleefuss-Lie, A., et al. Nat. Genet. 41(9):954-955(2009). Klaus, F., et al. Biochem. Biophys. Res. Commun. 381(3):407-411(2009).

Other Notes

Small volumes of anti-CLCN2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CLCN2 purchase

MBS6286354 is an antibody targeting CLCN2. Also known as CLCN2, NT (CLCN2, Chloride channel protein 2) (MaxLight 405). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CLCN2. It may not necessarily be applicable to this product.

NCBI GI #

283806618

NCBI GeneID

1181

NCBI Accession #

NP_001164559.1

UniProt Primary Accession #

P51788

UniProt Related Accession #

P51788

GenBank Nucleotide #

NP_001164559.1

NCBI Official Full Name

chloride channel protein 2 isoform 3

NCBI Official Synonym Full Names

chloride voltage-gated channel 2

NCBI Official Symbol

CLCN2

NCBI Official Synonym Symbols

CLC2; ECA2; ECA3; EGI3; EGMA; EJM6; EJM8; CIC-2; EGI11; HALD2; LKPAT; clC-2

UniProt Protein Name

Chloride channel protein 2

Protein Family

Chloride channel protein

UniProt Gene Name

CLCN2

UniProt Synonym Gene Names

ClC-2

UniProt Entry Name

CLCN2_HUMAN

NCBI Protein Information

chloride channel protein 2

NCBI Summary for CLCN2

This gene encodes a voltage-gated chloride channel. The encoded protein is a transmembrane protein that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]

UniProt Comments for CLCN2

CLCN2: Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. Defects in CLCN2 are associated with susceptibility to epilepsy, idiopathic generalized type 11 (EIG11). A disorder characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain. Defects in CLCN2 are associated with juvenile absence epilepsy type 2 (JAE2). JAE is a subtype of idiopathic generalized epilepsy (IGE) characterized by onset occurring around puberty, absence seizures, generalized tonic- clonic seizures (GTCS), GTCS on awakening and myoclonic seizures. Defects in CLCN2 are associated with juvenile myoclonic epilepsy type 8 (EJM8). A subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue. Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, chloride; Transporter, ion channel; Membrane protein, integral; Membrane protein, multi-pass; Transporter

Chromosomal Location of Human Ortholog: 3q27.1

Cellular Component: plasma membrane

Molecular Function: voltage-gated chloride channel activity

Biological Process: retina development in camera-type eye; transport; transmembrane transport

Disease: Epilepsy, Idiopathic Generalized, Susceptibility To, 11; Leukoencephalopathy With Ataxia

Research Articles on CLCN2

1. CLCN2 mutations cause primary aldosteronism, this highlight the importance of chloride in aldosterone biosynthesis and CLCN2 as the foremost chloride conductor of resting glomerulosa cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.