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CYP4B1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS628671

CYP4B1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CYP4B1, Polyclonal Antibody
Full Product Name
CYP4B1, ID (Cytochrome P450 4B1, CYPIVB1, Cytochrome P450-HP)
Product Gene Name
anti-CYP4B1 antibody
Product Synonym Names
Anti -CYP4B1, ID (Cytochrome P450 4B1, CYPIVB1, Cytochrome P450-HP)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human CYP4B1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
58,991 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (47264670..47285021). Location: 1p34-p12
OMIM
124075
3D Structure
ModBase 3D Structure for P13584
Immunogen
Synthetic peptide selected from the Center region of human CYP4B1 (KLH).

Product Categories/Family for anti-CYP4B1 antibody

Antibodies; Abs to Enzymes; Cytochrome
Applications Tested/Suitable for anti-CYP4B1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-CYP4B1 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100

Western Blot (WB) of anti-CYP4B1 antibody

Western blot analysis of CYP4B1 Antibody (Center) in MDA-MB468 cell line lysates (35ug/lane). CYP4B1 (arrow) was detected using the purified Pab.
Rabbit Anti-CYP4B1 Polyclonal Antibody – Cat# MBS628671

Immunohistochemistry (IHC) of anti-CYP4B1 antibody

Formalin-fixed and paraffin-embedded human lung carcinoma reacted with GLUL Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-CYP4B1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS628671

Immunofluorescence (IF) of anti-CYP4B1 antibody

Confocal immunofluorescent analysis of CYP4B1 Antibody (Center) with Hela cell followed by Alexa Fluor搴?488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Rabbit Anti-CYP4B1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS628671

Other Notes

Small volumes of anti-CYP4B1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CYP4B1 purchase

MBS628671 is an antibody targeting CYP4B1. Also known as CYP4B1, ID (Cytochrome P450 4B1, CYPIVB1, Cytochrome P450-HP). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CYP4B1. It may not necessarily be applicable to this product.

NCBI GI #
153218660
NCBI GeneID
1580
NCBI Accession #
NP_000770.2
UniProt Primary Accession #
P13584
UniProt Secondary Accession #
Q1HBI2; Q8TD85; Q8WWF2; Q8WWU9; Q8WWV0
UniProt Related Accession #
P13584; Q8IZB0; Q8WWV1
GenBank Nucleotide #
NM_000779.3
NCBI Official Full Name
cytochrome P450 4B1 isoform b
NCBI Official Synonym Full Names
cytochrome P450, family 4, subfamily B, polypeptide 1
NCBI Official Symbol
CYP4B1
NCBI Official Synonym Symbols
CYPIVB1; P-450HP
UniProt Protein Name
Cytochrome P450 4B1
UniProt Synonym Protein Names
CYPIVB1; Cytochrome P450-HP
Protein Family
Cytochrome
UniProt Gene Name
CYP4B1
UniProt Entry Name
CP4B1_HUMAN
NCBI Protein Information
cytochrome P450 4B1; OTTHUMP00000009678; OTTHUMP00000009679; OTTHUMP00000009680; OTTHUMP00000237949; cytochrome P450-HP; microsomal monooxygenase; cytochrome P450, subfamily IVB, polypeptide 1

NCBI Summary for CYP4B1

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. Two transcript variants encoding slightly different isoforms have been found for this gene. [provided by RefSeq]
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UniProt Comments for CYP4B1

CYP4B1: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.14.14.1; Oxidoreductase

Chromosomal Location of Human Ortholog: 1p33

Cellular Component: endoplasmic reticulum membrane

Molecular Function: iron ion binding; heme binding; drug binding; oxygen binding; fluorene oxygenase activity

Biological Process: fluorene metabolic process; biphenyl metabolic process; xenobiotic metabolic process; exogenous drug catabolic process
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Research Articles on CYP4B1

1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CYP4B1 antibody

 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Cytochrome P450 - Arranged By Substrate Type Pathway antibodies  Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
 Fatty Acids Pathway antibodies  Fatty Acids Pathway Diagram
 Nuclear Receptors In Lipid Metabolism And Toxicity Pathway antibodies  Nuclear Receptors In Lipid Metabolism And Toxicity Pathway Diagram
 Phase 1 - Functionalization Of Compounds Pathway antibodies  Phase 1 - Functionalization Of Compounds Pathway Diagram

Diseases associated with anti-CYP4B1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >23 publications with CYP4B1 and Neoplasms
 Drug Toxicity Antibodies  >16 publications with CYP4B1 and Drug Toxicity
 Inflammation Antibodies  >8 publications with CYP4B1 and Inflammation
 Carcinoma Antibodies  >8 publications with CYP4B1 and Carcinoma
 Liver Neoplasms Antibodies  >8 publications with CYP4B1 and Liver Neoplasms
 Lung Diseases Antibodies  >7 publications with CYP4B1 and Lung Diseases
 Death Antibodies  >7 publications with CYP4B1 and Death
 Liver Diseases Antibodies  >6 publications with CYP4B1 and Liver Diseases
 Female Urogenital Diseases Antibodies  >5 publications with CYP4B1 and Female Urogenital Diseases
 Lung Neoplasms Antibodies  >5 publications with CYP4B1 and Lung Neoplasms

Organs/Tissues associated with anti-CYP4B1 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >31 publications with CYP4B1 and Lung
 Kidney Antibodies  >15 publications with CYP4B1 and Kidney
 Eye Antibodies  >9 publications with CYP4B1 and Eye
 Intestine Antibodies  >9 publications with CYP4B1 and Intestine
 Bladder Antibodies  >7 publications with CYP4B1 and Bladder
 Prostate Antibodies  >4 publications with CYP4B1 and Prostate
 Brain Antibodies  >4 publications with CYP4B1 and Brain
 Placenta Antibodies  >3 publications with CYP4B1 and Placenta
 Heart Antibodies  >3 publications with CYP4B1 and Heart
 Mouth Antibodies  >2 publications with CYP4B1 and Mouth
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