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CLIP3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6286767

MBS6286767 is an antibody targeting CLIP3. Also known as CLIP3, CT (CLIP3, CLIPR59, CAP-Gly domain-containing linker protein 3, Cytoplasmic linker protein 170-related 59kD protein) (AP). Reactive in Human. Host: Rabbit. Functions as a cytoplasmic linker… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CLIP3, Polyclonal Antibody
Full Product Name
CLIP3, CT (CLIP3, CLIPR59, CAP-Gly domain-containing linker protein 3, Cytoplasmic linker protein 170-related 59kD protein) (AP)
Product Gene Name
anti-CLIP3 antibody
Product Synonym Names
CLIP3; CLIPR59; CAP-Gly domain-containing linker protein 3; Cytoplasmic linker protein 170-related 59kD protein
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
OMIM
607382
3D Structure
ModBase 3D Structure for Q96DZ5
Immunogen
CLIP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 368-396 amino acids from the C-terminal region of human CLIP3.
Conjugate
AP
Note
Preservative Free

Product Categories/Family for anti-CLIP3 antibody

Antibodies; Proteins
Applications Tested/Suitable for anti-CLIP3 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-CLIP3 antibody
WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-CLIP3 antibody

CLIP3 Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the CLIP3 antibody detected the CLIP3 protein (arrow).
Rabbit Anti-CLIP3 Polyclonal Antibody – Cat# MBS6286767

Flow Cytometry (FC/FACS) of anti-CLIP3 antibody

CLIP3 Antibody (C-term) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-CLIP3 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6286767

Product References and Citations for anti-CLIP3 antibody

Sorice, M., et al. PLoS ONE 5 (1), E8567 (2010): Ding, J., et al. Mol. Cell. Biol. 29(6):1459-1471(2009). Lallemand-Breitenbach, V., et al. J. Biol. Chem. 279(39):41168-41178(2004). Perez, F., et al. J. Cell Biol. 156(4):631-642(2002).

Other Notes

Small volumes of anti-CLIP3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CLIP3. It may not necessarily be applicable to this product.

NCBI GI #
18496983
NCBI GeneID
25999
NCBI Accession #
NP_056341.1
UniProt Primary Accession #
Q96DZ5
UniProt Related Accession #
Q96DZ5
GenBank Nucleotide #
NP_056341.1
NCBI Official Full Name
CAP-Gly domain-containing linker protein 3
NCBI Official Synonym Full Names
CAP-Gly domain containing linker protein 3
NCBI Official Symbol
CLIP3
NCBI Official Synonym Symbols
RSNL1; CLIPR59; CLIPR-59
UniProt Protein Name
CAP-Gly domain-containing linker protein 3
UniProt Synonym Protein Names
Cytoplasmic linker protein 170-related 59 kDa protein
Protein Family
CAP-Gly domain-containing linker protein
UniProt Gene Name
CLIP3
UniProt Synonym Gene Names
CLIPR59; CLIP-170-related 59 kDa protein; CLIPR-59
UniProt Entry Name
CLIP3_HUMAN
NCBI Protein Information
CAP-Gly domain-containing linker protein 3

NCBI Summary for CLIP3

This gene encodes a member of the cytoplasmic linker protein 170 family. Members of this protein family contain a cytoskeleton-associated protein glycine-rich domain and mediate the interaction of microtubules with cellular organelles. The encoded protein plays a role in T cell apoptosis by facilitating the association of tubulin and the lipid raft ganglioside GD3. The encoded protein also functions as a scaffold protein mediating membrane localization of phosphorylated protein kinase B. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
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UniProt Comments for CLIP3

CLIPR-59: Functions as a cytoplasmic linker protein. Involved in TGN-endosome dynamics.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 19q13.12

Cellular Component: Golgi stack; early endosome membrane; recycling endosome membrane; plasma membrane; trans-Golgi network membrane; trans-Golgi network; lipid raft

Molecular Function: microtubule binding

Biological Process: peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine; fat cell differentiation; positive regulation of apoptosis; negative regulation of microtubule polymerization; positive regulation of endocytosis; positive regulation of protein amino acid phosphorylation
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Research Articles on CLIP3

1. this study indicates that inhibition of miRNA-593-3p by insulin promotes glucose metabolism through the regulation of Slc38a1 and CLIP3 expression, and provides a new insight into the role and mechanism of insulin-induced glycolysis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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