Rabbit Anti-CNTROB Polyclonal Antibody – Cat# MBS6287406

CNTROB Antibody (Center) western blot analysis in mouse Neuro-2a cell line lysates (35ug/lane).This demonstrates the CNTROB antibody detected the CNTROB protein (arrow).

CNTROB Antibody – Rabbit Polyclonal

Name: CNTROB Antibody; Polyclonal; Rabbit; Human/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6287406
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6287406

CNTROB is a centrosomal protein that interacts with BRCA2 (MIM 600185) and is required for centriole duplication and cytokinesis (Zou et al., 2005 [PubMed 16275750]).[supplied by OMIM]. More details

$1060 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CNTROB, Polyclonal Antibody

Full Product Name

CNTROB, ID (CNTROB, LIP8, Centrobin, Centrosomal BRCA2-interacting protein, LYST-interacting protein 8) (APC)

Product Gene Name

anti-CNTROB antibody

Product Synonym Names

CNTROB; LIP8; Centrobin; Centrosomal BRCA2-interacting protein; LYST-interacting protein 8

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

101,253 Da

Chromosome Location

Chromosome: 17; NC_000017.10 (7835442..7853237). Location: 17p13.1

OMIM

611425

3D Structure

ModBase 3D Structure for Q8N137

Immunogen

CNTROB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 400-430 amino acids from the Central region of human CNTROB.

Conjugate

APC

Note

Preservative Free

Special Handling

Light sensitive

Product Categories/Family for anti-CNTROB antibody

Antibodies; Centrosomal Proteins

Applications Tested/Suitable for anti-CNTROB antibody

Western Blot (WB), FLISA

Application Notes for anti-CNTROB antibody

WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-CNTROB antibody

Lee, J., et al. J. Biol. Chem. 285(33):25476-25484(2010). Olson, J.E., et al. Breast Cancer Res. Treat. (2010). In press: Jeffery, J.M., et al. Oncogene 29(18):2649-2658(2010). Song, L., et al. Cell. Signal. 22(5):857-864(2010). Jeong, Y., et al. J. Cell. Sci. 120 (PT 12), 2106-2116 (2007).

Other Notes

Small volumes of anti-CNTROB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CNTROB purchase

MBS6287406 is an antibody targeting CNTROB. Also known as CNTROB, ID (CNTROB, LIP8, Centrobin, Centrosomal BRCA2-interacting protein, LYST-interacting protein 8) (APC). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CNTROB. It may not necessarily be applicable to this product.

NCBI GI #

191252785

NCBI GeneID

116840

NCBI Accession #

NP_444279.2

UniProt Primary Accession #

Q8N137

UniProt Secondary Accession #

Q331K3; Q69YV7; Q8NCB8; Q8WXV3; Q96CQ7; Q9C060; A6NHQ1

UniProt Related Accession #

Q8N137

GenBank Nucleotide #

NM_053051.3

NCBI Official Full Name

centrobin isoform alpha

NCBI Official Synonym Full Names

centrobin, centrosomal BRCA2 interacting protein

NCBI Official Symbol

CNTROB

NCBI Official Synonym Symbols

LIP8; PP1221

UniProt Protein Name

Centrobin

UniProt Synonym Protein Names

Centrosomal BRCA2-interacting protein; LYST-interacting protein 8

Protein Family

Centrobin

UniProt Gene Name

CNTROB

UniProt Synonym Gene Names

LIP8

UniProt Entry Name

CNTRB_HUMAN

NCBI Protein Information

centrobin; LYST-interacting protein 8; LYST-interacting protein LIP8; centrosomal BRCA2-interacting protein

NCBI Summary for CNTROB

This gene encodes a centrosomal protein that interacts with BRCA2, and is required for centriole duplication and cytokinesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

UniProt Comments for CNTROB

LIP8: Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: centriole; centrosome; cytoplasm

Molecular Function: protein domain specific binding; protein binding

Biological Process: centrosome separation; centriole replication

Research Articles on CNTROB

1. it is proposed that Centrobin might regulate microtubule nucleation and organization by controlling the amount of pericentriolar matrix

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CNTROB antibody

Reference Product	PubMed Publications
NEK2 antibody	>4 publications with CNTROB and NEK2
PLK1 antibody	>2 publications with CNTROB and PLK1

Organs/Tissues associated with anti-CNTROB antibody

Organ/Tissue Name	Pubmed Publications
Epididymis Antibodies	>1 publications with CNTROB and Epididymis
Lung Antibodies	>1 publications with CNTROB and Lung
Embryonic Tissue Antibodies	>1 publications with CNTROB and Embryonic Tissue
Brain Antibodies	>1 publications with CNTROB and Brain