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MAGEL2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS628774

Melanoma-associated antigen (MAGE) are completely silent in normal tissues, with the exception of male germ cells, and, for some of them, placenta. These antigens ought to be strictly tumor specific, expressed in tumor cells of various histological types.… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
MAGEL2, Polyclonal Antibody
Full Product Name
MAGEL2, CT (MAGE-like Protein 2, Necdin-like Protein 1, Protein nM15, NDNL1)
Product Gene Name
anti-MAGEL2 antibody
Product Synonym Names
Anti -MAGEL2, CT (MAGE-like Protein 2, Necdin-like Protein 1, Protein nM15, NDNL1)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human MAGEL2.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
72,236 Da
Chromosome Location
Chromosome: 15; NC_000015.9 (23888696..23892993, complement). Location: 15q11-q12
3D Structure
ModBase 3D Structure for Q05BN9
Immunogen
Synthetic peptide selected from the C-terminal region of human MAGEL2 (KLH).

Product Categories/Family for anti-MAGEL2 antibody

Antibodies; Abs to Cancer Markers
Applications Tested/Suitable for anti-MAGEL2 antibody
ELISA (EL/EIA), Immunohistochemistry (IHC)
Application Notes for anti-MAGEL2 antibody
Suitable for use in ELISA and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Immunohistochemistry: 1:50-1:100

Western Blot (WB) of anti-MAGEL2 antibody

MAGEL2 Antibody (D514) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the MAGEL2 antibody detected the MAGEL2 protein (arrow).
Rabbit Anti-MAGEL2 Polyclonal Antibody – Cat# MBS628774

Immunohistochemistry (IHC) of anti-MAGEL2 antibody

MAGEL2 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MAGEL2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-MAGEL2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS628774

Other Notes

Small volumes of anti-MAGEL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MAGEL2 purchase

MBS628774 is an antibody targeting MAGEL2. Also known as MAGEL2, CT (MAGE-like Protein 2, Necdin-like Protein 1, Protein nM15, NDNL1). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MAGEL2. It may not necessarily be applicable to this product.

NCBI GI #
257900508
NCBI GeneID
54551
NCBI Accession #
NP_061939.3
UniProt Primary Accession #
Q05BN9
UniProt Related Accession #
Q05BN9; Q2M1Q7; Q6P3U4; Q9UJ55
GenBank Nucleotide #
NM_019066.4
NCBI Official Full Name
MAGE-like protein 2
NCBI Official Synonym Full Names
MAGE-like 2
NCBI Official Symbol
MAGEL2
NCBI Official Synonym Symbols
nM15; NDNL1
UniProt Protein Name
MAGEL2 protein
Protein Family
MAGE-like protein
UniProt Gene Name
MAGEL2
UniProt Entry Name
Q05BN9_HUMAN
NCBI Protein Information
MAGE-like protein 2; protein nM15; OTTHUMP00000236233; necdin-like protein 1

NCBI Summary for MAGEL2

Prader-Willi syndrome (PWS) is caused by the loss of expression of imprinted genes in chromosome 15q11-q13 region. Affected individuals exhibit neonatal hypotonia, developmental delay, and childhood-onset obesity. Necdin (NDN), a gene involved in the terminal differentiation of neurons, localizes to this region of the genome and has been implicated as one of the genes responsible for the etiology of PWS. This gene is structurally similar to NDN, is also localized to the PWS chromosomal region, and is paternally imprinted, suggesting a possible role for it in PWS. [provided by RefSeq]
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UniProt Comments for MAGEL2

MAGE-L2: May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Interacts with TRIM27

Chromosomal Location of Human Ortholog: 15q11.2

Cellular Component: retromer complex; early endosome; nucleus; endosome

Molecular Function: protein binding; ubiquitin-protein ligase activity

Biological Process: transcription, DNA-dependent; rhythmic process; negative regulation of transcription, DNA-dependent; regulation of circadian rhythm; retrograde transport, endosome to Golgi

Disease: Prader-willi Syndrome; Prader-willi-like Syndrome
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Research Articles on MAGEL2

1. Results suggest that MAGEL2 may not play a role in the pathophysiology of schizophrenia and mood disorders in the Japanese population.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-MAGEL2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >12 publications with MAGEL2 and Brain
 Embryonic Tissue Antibodies  >4 publications with MAGEL2 and Embryonic Tissue
 Lung Antibodies  >2 publications with MAGEL2 and Lung
 Testis Antibodies  >1 publications with MAGEL2 and Testis
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