Rabbit Anti-COL9A3 Polyclonal Antibody – Cat# MBS6287778

COL9A3 Antibody (Center) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the COL9A3 antibody detected the COL9A3 protein (arrow).

COL9A3 Antibody – Rabbit Polyclonal

Name: COL9A3 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6287778
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6287778

This gene encodes one of the three alpha chains of type IX collagen, the major collagen component of hyaline cartilage. Type IX collagen, a heterotrimeric molecule, is usually found in tissues containing type II collagen, a fibrillar collagen. Mutations in… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

COL9A3, Polyclonal Antibody

Full Product Name

COL9A3, ID (COL9A3, Collagen alpha-3(IX) chain) (PE)

Product Gene Name

anti-COL9A3 antibody

Product Synonym Names

COL9A3; Collagen alpha-3(IX) chain

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

63,616 Da

Chromosome Location

Chromosome: 20; NC_000020.10 (61448414..61472511). Location: 20q13.3

OMIM

120270

3D Structure

ModBase 3D Structure for Q14050

Immunogen

COL9A3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 501-529 amino acids from the Central region of human COL9A3.

Conjugate

Note

Preservative Free

Special Handling

Light sensitive

Product Categories/Family for anti-COL9A3 antibody

Antibodies; Collagen

Applications Tested/Suitable for anti-COL9A3 antibody

Western Blot (WB), FLISA

Application Notes for anti-COL9A3 antibody

WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-COL9A3 antibody

Jackson, G.C., et al. Am. J. Med. Genet. A 152A (4), 863-869 (2010): Videman, T., et al. Arthritis Rheum. 60(2):470-481(2009). Karppinen, J., et al. Spine 33(11):1236-1241(2008). Decramer, S., et al. World J Urol 25(5):457-465(2007). Virtanen, I.M., et al. Spine 32(10):1129-1134(2007).

Other Notes

Small volumes of anti-COL9A3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for COL9A3 purchase

MBS6287778 is an antibody targeting COL9A3. Also known as COL9A3, ID (COL9A3, Collagen alpha-3(IX) chain) (PE). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for COL9A3. It may not necessarily be applicable to this product.

NCBI GI #

119508426

NCBI GeneID

1299

NCBI Accession #

NP_001844.3

UniProt Primary Accession #

Q14050

UniProt Secondary Accession #

Q13681; Q9H4G9; Q9UPE2

UniProt Related Accession #

Q14050

GenBank Nucleotide #

NM_001853.3

NCBI Official Full Name

collagen alpha-3(IX) chain

NCBI Official Synonym Full Names

collagen, type IX, alpha 3

NCBI Official Symbol

COL9A3

NCBI Official Synonym Symbols

IDD; MED; EDM3; DJ885L7.4.1

UniProt Protein Name

Collagen alpha-3(IX) chain

Protein Family

Collagen

UniProt Gene Name

COL9A3

UniProt Entry Name

CO9A3_HUMAN

NCBI Protein Information

collagen alpha-3(IX) chain; collagen alpha-3(IX) chain; collagen type IX proteoglycan; collagen IX, alpha-3 polypeptide

UniProt Comments for COL9A3

COL9A3: Structural component of hyaline cartilage and vitreous of the eye. Defects in COL9A3 are the cause of multiple epiphyseal dysplasia type 3 (EDM3); also known as multiple epiphyseal dysplasia with myopathy. EDM is a generalized skeletal dysplasia associated with significant morbidity. Joint pain, joint deformity, waddling gait, and short stature are the main clinical signs and symptoms. EDM is broadly categorized into the more severe Fairbank and the milder Ribbing types. Defects in COL9A3 are a cause of susceptibility to intervertebral disk disease (IDD). A common musculo- skeletal disorder caused by degeneration of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain. Susceptibility to intervertebral disk disease, is conferred by variant p.Arg103Trp (PubMed:11308397). Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 20q13.3

Cellular Component: proteinaceous extracellular matrix; endoplasmic reticulum lumen; extracellular region

Molecular Function: extracellular matrix structural constituent conferring tensile strength

Biological Process: extracellular matrix disassembly; axon guidance; collagen catabolic process; extracellular matrix organization and biogenesis; male gonad development; female gonad development

Disease: Epiphyseal Dysplasia, Multiple, 3; Intervertebral Disc Disease

Research Articles on COL9A3

1. The NC2 domain of type IX collagen determines the chain composition but also the chain register of the triple helix.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-COL9A3 antibody

Reference Product	PubMed Publications
COL2A1 antibody	>8 publications with COL9A3 and COL2A1

Pathways associated with anti-COL9A3 antibody

Products by Pathway	Pathway Diagram
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Collagen Formation Pathway antibodies	Collagen Formation Pathway Diagram
Degradation Of Collagen Pathway antibodies	Degradation Of Collagen Pathway Diagram
Degradation Of The Extracellular Matrix Pathway antibodies	Degradation Of The Extracellular Matrix Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram
Gastric Cancer Network 2 Pathway antibodies	Gastric Cancer Network 2 Pathway Diagram
NCAM Signaling For Neurite Out-growth Pathway antibodies	NCAM Signaling For Neurite Out-growth Pathway Diagram
NCAM1 Interactions Pathway antibodies	NCAM1 Interactions Pathway Diagram

Diseases associated with anti-COL9A3 antibody

Disease Name	Pubmed Publications
Epiphyseal dysplasia, multiple, 3 Antibodies	>16 publications with COL9A3 and Epiphyseal dysplasia, multiple, 3
Intervertebral disc disease Antibodies	>5 publications with COL9A3 and Intervertebral disc disease
Peripheral Nervous System Diseases Antibodies	>1 publications with COL9A3 and Peripheral Nervous System Diseases

Organs/Tissues associated with anti-COL9A3 antibody

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>21 publications with COL9A3 and Bone
Blood Antibodies	>8 publications with COL9A3 and Blood
Connective Tissue Antibodies	>8 publications with COL9A3 and Connective Tissue
Testis Antibodies	>3 publications with COL9A3 and Testis
Ear Antibodies	>3 publications with COL9A3 and Ear
Ovary Antibodies	>2 publications with COL9A3 and Ovary
Eye Antibodies	>2 publications with COL9A3 and Eye
Kidney Antibodies	>1 publications with COL9A3 and Kidney
Embryonic Tissue Antibodies	>1 publications with COL9A3 and Embryonic Tissue
Brain Antibodies	>1 publications with COL9A3 and Brain