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ELMO1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS628800

ELMO1 interacts with the dedicator of cyto-kinesis 1 protein to promote phagocytosis and effect cell shape changes. Similarity to a C. elegans protein suggests that this protein may function in apoptosis and in cell migration. More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
ELMO1, Polyclonal Antibody
Full Product Name
ELMO1, ID (Protein Ced-12 Homolog, Engulfment And Cell Motility Protein 1, KIAA0281)
Product Gene Name
anti-ELMO1 antibody
Product Synonym Names
Anti -ELMO1, ID (Protein Ced-12 Homolog, Engulfment And Cell Motility Protein 1, KIAA0281)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human ELMO1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
83,829 Da
Chromosome Location
Chromosome: 7; NC_000007.13 (36892511..37488895, complement). Location: 7p14.1
OMIM
606420
3D Structure
ModBase 3D Structure for Q92556
Immunogen
Synthetic peptide selected from the Center region of human ELMO1 (KLH).

Product Categories/Family for anti-ELMO1 antibody

Antibodies; Abs to Apoptosis
Applications Tested/Suitable for anti-ELMO1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-ELMO1 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500

Western Blot (WB) of anti-ELMO1 antibody

Western blot analysis of ELMO1 Antibody (Center) in Ramos cell line lysates (35ug/lane). ELMO1 (arrow) was detected using the purified Pab.
Rabbit Anti-ELMO1 Polyclonal Antibody – Cat# MBS628800

Flow Cytometry (FC/FACS) of anti-ELMO1 antibody

ELMO1 Antibody (Center) flow cytometry analysis of Ramos cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-ELMO1 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS628800

Other Notes

Small volumes of anti-ELMO1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ELMO1 purchase

MBS628800 is an antibody targeting ELMO1. Also known as ELMO1, ID (Protein Ced-12 Homolog, Engulfment And Cell Motility Protein 1, KIAA0281). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ELMO1. It may not necessarily be applicable to this product.

NCBI GI #
18765702
NCBI GeneID
9844
NCBI Accession #
NP_569709.1
UniProt Primary Accession #
Q92556
UniProt Secondary Accession #
Q29R79; Q6ZTJ0; Q96PB0; Q9H0I1; A4D1X6
UniProt Related Accession #
Q92556
GenBank Nucleotide #
NM_130442.3
NCBI Official Full Name
engulfment and cell motility protein 1 isoform 2
NCBI Official Synonym Full Names
engulfment and cell motility 1
NCBI Official Symbol
ELMO1
NCBI Official Synonym Symbols
CED12; CED-12; ELMO-1
UniProt Protein Name
Engulfment and cell motility protein 1
UniProt Synonym Protein Names
Protein ced-12 homolog
Protein Family
Engulfment and cell motility protein
UniProt Gene Name
ELMO1
UniProt Synonym Gene Names
KIAA0281
UniProt Entry Name
ELMO1_HUMAN
NCBI Protein Information
engulfment and cell motility protein 1; ced-12 homolog 1

NCBI Summary for ELMO1

This gene encodes a member of the engulfment and cell motility protein family. These proteins interact with dedicator of cytokinesis proteins to promote phagocytosis and cell migration. Increased expression of this gene and dedicator of cytokinesis 1 may promote glioma cell invasion, and single nucleotide polymorphisms in this gene may be associated with diabetic nephropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
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UniProt Comments for ELMO1

ELMO1: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 7p14.1

Cellular Component: cytoskeleton; membrane; cytoplasm; plasma membrane; cytosol

Molecular Function: protein binding; SH3 domain binding

Biological Process: viral reproduction; apoptosis; Rac protein signal transduction; innate immune response; vascular endothelial growth factor receptor signaling pathway; phagocytosis, engulfment; cell motility; actin cytoskeleton organization and biogenesis; regulation of defense response to virus by virus
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Research Articles on ELMO1

1. ELMO1 mutations are associated with esophageal adenocarcinoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ELMO1 antibody

 Reference Product  PubMed Publications
 RAC1 antibody  >27 publications with ELMO1 and RAC1
 DOCK1 antibody  >24 publications with ELMO1 and DOCK1
 RHOG antibody  >10 publications with ELMO1 and RHOG
 CRK antibody  >9 publications with ELMO1 and CRK
 SRC antibody  >8 publications with ELMO1 and SRC
 RAC2 antibody  >3 publications with ELMO1 and RAC2
 HCK antibody  >2 publications with ELMO1 and HCK

Pathways associated with anti-ELMO1 antibody

 Products by Pathway  Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway antibodies  Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway Diagram
 HIV Infection Pathway antibodies  HIV Infection Pathway Diagram
 Host Interactions Of HIV Factors Pathway antibodies  Host Interactions Of HIV Factors Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram

Diseases associated with anti-ELMO1 antibody

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >15 publications with ELMO1 and Kidney Diseases
 Neoplasms Antibodies  >6 publications with ELMO1 and Neoplasms
 Proteinuria Antibodies  >5 publications with ELMO1 and Proteinuria
 Immune System Diseases Antibodies  >5 publications with ELMO1 and Immune System Diseases
 Renal Insufficiency Antibodies  >4 publications with ELMO1 and Renal Insufficiency
 Inflammation Antibodies  >2 publications with ELMO1 and Inflammation
 Brain Diseases Antibodies  >2 publications with ELMO1 and Brain Diseases
 Vascular Diseases Antibodies  >2 publications with ELMO1 and Vascular Diseases
 Nervous System Diseases Antibodies  >2 publications with ELMO1 and Nervous System Diseases
 Neoplasms, Experimental Antibodies  >1 publications with ELMO1 and Neoplasms, Experimental

Organs/Tissues associated with anti-ELMO1 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >12 publications with ELMO1 and Kidney
 Brain Antibodies  >10 publications with ELMO1 and Brain
 Blood Antibodies  >8 publications with ELMO1 and Blood
 Testis Antibodies  >3 publications with ELMO1 and Testis
 Lung Antibodies  >2 publications with ELMO1 and Lung
 Lymph Antibodies  >1 publications with ELMO1 and Lymph
 Lymph Node Antibodies  >1 publications with ELMO1 and Lymph Node
 Muscle Antibodies  >1 publications with ELMO1 and Muscle
 Thymus Antibodies  >1 publications with ELMO1 and Thymus
 Thyroid Antibodies  >1 publications with ELMO1 and Thyroid
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