Glutaredoxin-2, Mitochondrial, T135 (GLRX2) Antibody – Rabbit Polyclonal

GLRX2: Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release. Belongs to the glutaredoxin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; Oxidoreductase

Chromosomal Location of Human Ortholog: 1q31.2

Cellular Component: nucleoplasm; intracellular membrane-bound organelle; mitochondrion; nucleus

Molecular Function: 2 iron, 2 sulfur cluster binding; electron carrier activity; metal ion binding; protein disulfide isomerase activity; protein disulfide oxidoreductase activity; arsenate reductase (glutaredoxin) activity; glutathione disulfide oxidoreductase activity

Biological Process: response to organic substance; response to temperature stimulus; DNA protection; glutathione metabolic process; response to hydrogen peroxide; protein folding; regulation of transcription, DNA-dependent; cell redox homeostasis; apoptosis; regulation of signal transduction; response to redox state; cell differentiation