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FKBP1B Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS628859

FKBP1B is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and… More details

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Product Overview

Online Datasheet in PDF
Product Name
FKBP1B, Polyclonal Antibody
Full Product Name
FKBP1B, NT (E6) (h-FKBP-12, Immunophilin FKBP12.6, 12.6kD FK506-binding Protein, 12.6kD FKBP, FKBP-12.6, Rotamase, FK506-binding Protein 1B, FKBP-1B, Peptidyl-prolyl cis-trans Isomerase FKBP1B, PPIase FKBP1B, FKBP12.6, FKBP1L, FKBP9, OTK4)
Product Gene Name
anti-FKBP1B antibody
Product Synonym Names
Anti -FKBP1B, NT (E6) (h-FKBP-12, Immunophilin FKBP12.6, 12.6kD FK506-binding Protein, 12.6kD FKBP, FKBP-12.6, Rotamase, FK506-binding Protein 1B, FKBP-1B, Peptidyl-prolyl cis-trans Isomerase FKBP1B, PPIase FKBP1B, FKBP12.6, FKBP1L, FKBP9, OTK4)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human FKBP1B. Species Crossreactivity: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
11,783 Da
Chromosome Location
Chromosome: 11; NC_007309.4 (77234374..77245241, complement)
3D Structure
ModBase 3D Structure for P68107
Immunogen
KLH-conjugated synthetic peptide corresponding to a portion of amino acids within aa1-30 from the N-terminal region of human FKBP1B.

Product Categories/Family for anti-FKBP1B antibody

Antibodies; Abs to Binding Proteins
Applications Tested/Suitable for anti-FKBP1B antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-FKBP1B antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1000
Western Blot: 1:50-1:100

Western Blot (WB) of anti-FKBP1B antibody

Western blot analysis of anti-FKBP1B Antibody (N-term E6) in CEM cell line lysates (35ug/lane). FKBP1B (arrow) was detected using the purified Pab.
Rabbit Anti-FKBP1B Polyclonal Antibody – Cat# MBS628859

Western Blot (WB) of anti-FKBP1B antibody

Western blot analysis of anti-FKBP1B Antibody (N-term E6) in mouse cerebellum tissue lysates (35ug/lane). FKBP1B (arrow) was detected using the purified Pab.
Rabbit Anti-FKBP1B Polyclonal Antibody, Western Blot (WB) – Cat# MBS628859

Immunofluorescence (IF) of anti-FKBP1B antibody

Confocal immunofluorescent analysis of FKBP1B Antibody (N-term E6) with 293 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Rabbit Anti-FKBP1B Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS628859

Other Notes

Small volumes of anti-FKBP1B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FKBP1B purchase

MBS628859 is an antibody targeting FKBP1B. Also known as FKBP1B, NT (E6) (h-FKBP-12, Immunophilin FKBP12.6, 12.6kD FK506-binding Protein, 12.6kD FKBP, FKBP-12.6, Rotamase, FK506-binding Protein 1B, FKBP-1B, Peptidyl-prolyl cis-trans Isomerase FKBP1B, PPIase FKBP1B, FKBP12.6, FKBP1L, FKBP9, OTK4). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FKBP1B. It may not necessarily be applicable to this product.

NCBI GI #
296482331
NCBI GeneID
785179
UniProt Primary Accession #
P68107
UniProt Secondary Accession #
Q13664; Q16645; Q9BQ40; A5D7G8
UniProt Related Accession #
P68107
NCBI Official Full Name
FK506 binding protein 1B, 12.6 kDa
NCBI Official Symbol
FKBP1B
NCBI Official Synonym Symbols
FKBP12.6
UniProt Protein Name
Peptidyl-prolyl cis-trans isomerase FKBP1B
UniProt Synonym Protein Names
12.6 kDa FK506-binding protein; 12.6 kDa FKBP; FKBP-12.6; FK506-binding protein 1B; FKBP-1B; Immunophilin FKBP12.6; Rotamase
Protein Family
Peptidyl-prolyl cis-trans isomerase
UniProt Gene Name
FKBP1B
UniProt Synonym Gene Names
FKBP12.6
UniProt Entry Name
FKB1B_BOVIN
NCBI Protein Information
peptidyl-prolyl cis-trans isomerase FKBP1B; FKBP-1B; FKBP-12.6; PPIase 1B; Rotamase 1B; 12.6 kDa FKBP; PPIase FKBP1B; Immunophilin FKBP12.6; FK506-binding protein 1B; 12.6 kDa FK506-binding protein; peptidyl-prolyl cis-trans isomerase 1B; peptidyl-prolyl cis-trans isomerase; PPIase

UniProt Comments for FKBP1B

FKBP1B: Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Belongs to the FKBP-type PPIase family. FKBP1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Isomerase; EC 5.2.1.8

Chromosomal Location of Human Ortholog: 2p23.3

Cellular Component: sarcoplasmic reticulum membrane; membrane; cytoplasm; cytosol; Z disc

Molecular Function: protein binding; FK506 binding; peptidyl-prolyl cis-trans isomerase activity; cyclic nucleotide binding; calcium channel inhibitor activity; ryanodine-sensitive calcium-release channel activity; receptor binding

Biological Process: positive regulation of sequestering of calcium ion; positive regulation of axon regeneration; protein maturation via protein folding; protein peptidyl-prolyl isomerization; negative regulation of heart rate; cytosolic calcium ion homeostasis; response to redox state; release of sequestered calcium ion by sarcoplasmic reticulum into cytosol; T cell proliferation; negative regulation of protein phosphatase type 2B activity; response to vitamin E; 'de novo' protein folding; smooth muscle contraction; response to hydrogen peroxide; insulin secretion; negative regulation of release of sequestered calcium ion into cytosol; action potential propagation; response to glucose stimulus; protein refolding; transmembrane transport
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-FKBP1B antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >3 publications with FKBP1B and Cardiovascular Diseases
 Hyperplasia Antibodies  >1 publications with FKBP1B and Hyperplasia
 Death Antibodies  >1 publications with FKBP1B and Death
 Immune System Diseases Antibodies  >1 publications with FKBP1B and Immune System Diseases

Organs/Tissues associated with anti-FKBP1B antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1 publications with FKBP1B and Brain
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