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FOXC1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS628885

Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. More details

$895 / 0.2 mL +1 FREE 8GB USB
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
FOXC1, Polyclonal Antibody
Full Product Name
FOXC1, CT (Forkhead-related Transcription Factor 3, FREAC-3, Forkhead-related Protein FKHL7, Forkhead Box Protein C1, FKHL7, FREAC3)
Product Gene Name
anti-FOXC1 antibody
Product Synonym Names
Anti -FOXC1, CT (Forkhead-related Transcription Factor 3, FREAC-3, Forkhead-related Protein FKHL7, Forkhead Box Protein C1, FKHL7, FREAC3)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human CYP2E1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
56,789 Da
Chromosome Location
Chromosome: 6; NC_000006.11 (1610681..1614132). Location: 6p25
OMIM
601090
3D Structure
ModBase 3D Structure for Q12948
Immunogen
Synthetic peptide selected from the C-terminal region of human FOXC1 (KLH).

Product Categories/Family for anti-FOXC1 antibody

Antibodies; Abs to Transcription Factors
Applications Tested/Suitable for anti-FOXC1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-FOXC1 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500

Western Blot (WB) of anti-FOXC1 antibody

Western blot analysis of FOXC1 Antibody (C-term) in 293 cell line lysates (35ug/lane). FOXC1 (arrow) was detected using the purified Pab.
Rabbit Anti-FOXC1 Polyclonal Antibody – Cat# MBS628885

Flow Cytometry (FC/FACS) of anti-FOXC1 antibody

FOXC1 Antibody (C-term) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-FOXC1 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS628885

Other Notes

Small volumes of anti-FOXC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FOXC1 purchase

MBS628885 is an antibody targeting FOXC1. Also known as FOXC1, CT (Forkhead-related Transcription Factor 3, FREAC-3, Forkhead-related Protein FKHL7, Forkhead Box Protein C1, FKHL7, FREAC3). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FOXC1. It may not necessarily be applicable to this product.

NCBI GI #
119395716
NCBI GeneID
2296
NCBI Accession #
NP_001444.2
UniProt Primary Accession #
Q12948
UniProt Secondary Accession #
Q86UP7; Q9BYM1; Q9NUE5; Q9UDD0; Q9UP06
UniProt Related Accession #
Q12948
GenBank Nucleotide #
NM_001453.2
NCBI Official Full Name
forkhead box protein C1
NCBI Official Synonym Full Names
forkhead box C1
NCBI Official Symbol
FOXC1
NCBI Official Synonym Symbols
ARA; IGDA; IHG1; FKHL7; IRID1; RIEG3; FREAC3; FREAC-3
UniProt Protein Name
Forkhead box protein C1
UniProt Synonym Protein Names
Forkhead-related protein FKHL7; Forkhead-related transcription factor 3
Protein Family
Forkhead box protein
UniProt Gene Name
FOXC1
UniProt Synonym Gene Names
FKHL7; FREAC3
UniProt Entry Name
FOXC1_HUMAN
NCBI Protein Information
forkhead box protein C1; OTTHUMP00000017802; myeloid factor-delta; forkhead-related activator 3; forkhead-related protein FKHL7; forkhead, drosophila, homolog-like 7; forkhead-related transcription factor 3; forkhead/winged helix-like transcription factor 7

NCBI Summary for FOXC1

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly. [provided by RefSeq]
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UniProt Comments for FOXC1

FOXC1: Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Monomer. Expressed in all tissues and cell lines examined.

Protein type: Transcription factor; DNA-binding; Cell cycle regulation; Cell development/differentiation

Chromosomal Location of Human Ortholog: 6p25

Cellular Component: nucleoplasm; cytoplasm; nuclear heterochromatin; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; DNA binding; sequence-specific DNA binding; DNA bending activity; transcription factor binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; collagen fibril organization; glycosaminoglycan metabolic process; neural crest cell development; paraxial mesoderm formation; heart development; positive regulation of transcription, DNA-dependent; cardiac muscle cell proliferation; ovarian follicle development; regulation of transcription, DNA-dependent; ureteric bud development; germ cell migration; ventricular cardiac muscle morphogenesis; negative regulation of mitotic cell cycle; lacrimal gland development; regulation of blood vessel size; skeletal development; mesenchymal cell development; Notch signaling pathway; cell migration; somitogenesis; ossification; camera-type eye development; in utero embryonic development; regulation of organ growth; odontogenesis of dentine-containing teeth; cell proliferation; eye development; embryonic heart tube development; artery morphogenesis; positive regulation of transcription from RNA polymerase II promoter; blood vessel remodeling; brain development; lymph vessel development; vascular endothelial growth factor receptor signaling pathway

Disease: Axenfeld-rieger Syndrome, Type 3; Iridogoniodysgenesis, Type 1
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Research Articles on FOXC1

1. FOXC1 and PITX2 genetic defects explain 40% of our large anterior segment malformations.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-FOXC1 antibody

 Products by Pathway  Pathway Diagram
 Heart Development Pathway antibodies  Heart Development Pathway Diagram

Diseases associated with anti-FOXC1 antibody

 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >81 publications with FOXC1 and Congenital Abnormalities
 Eye Abnormalities Antibodies  >76 publications with FOXC1 and Eye Abnormalities
 Neoplasms Antibodies  >13 publications with FOXC1 and Neoplasms
 Craniofacial Abnormalities Antibodies  >10 publications with FOXC1 and Craniofacial Abnormalities
 Hearing Loss Antibodies  >9 publications with FOXC1 and Hearing Loss
 Skin Diseases Antibodies  >8 publications with FOXC1 and Skin Diseases
 Breast Neoplasms Antibodies  >6 publications with FOXC1 and Breast Neoplasms
 Carcinoma Antibodies  >5 publications with FOXC1 and Carcinoma
 Heart Defects, Congenital Antibodies  >5 publications with FOXC1 and Heart Defects, Congenital
 Nervous System Malformations Antibodies  >4 publications with FOXC1 and Nervous System Malformations

Organs/Tissues associated with anti-FOXC1 antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >106 publications with FOXC1 and Eye
 Embryonic Tissue Antibodies  >20 publications with FOXC1 and Embryonic Tissue
 Bone Antibodies  >14 publications with FOXC1 and Bone
 Heart Antibodies  >11 publications with FOXC1 and Heart
 Kidney Antibodies  >10 publications with FOXC1 and Kidney
 Vascular Antibodies  >10 publications with FOXC1 and Vascular
 Brain Antibodies  >8 publications with FOXC1 and Brain
 Nerve Antibodies  >8 publications with FOXC1 and Nerve
 Prostate Antibodies  >4 publications with FOXC1 and Prostate
 Skin Antibodies  >3 publications with FOXC1 and Skin
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