Opioid Receptor, Mu (OPRM1) Antibody – Rabbit Polyclonal

This gene encodes one of three opioid receptors. The mu opioid receptor is the principal target of endogenous opioid peptides and opioid analgesic agents such a s beta-endorphn and enkephalins. The NM_001008503.1:c.118A>G allele had been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]

MOR-1: a Gi-protein-coupled receptor for beta-endorphin, morphine and other opiates. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Ligand-binding inactivates adenylyl cyclase, and activates a variety of G-beta-gamma-dependent pathways including the MAPK and the PI3K/Akt cascades. Two splice-variant isoforms have been described.

Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1

Chromosomal Location of Human Ortholog: 6q24-q25

Cellular Component: dendrite cytoplasm; Golgi apparatus; neuron projection; focal adhesion; integral to plasma membrane; endoplasmic reticulum; plasma membrane; perikaryon; sarcolemma; lipid raft

Molecular Function: voltage-gated calcium channel activity; G-protein coupled receptor activity; neuropeptide binding; protein domain specific binding; protein binding; G-protein beta-subunit binding; G-protein alpha-subunit binding; filamin binding; beta-endorphin receptor activity

Biological Process: positive regulation of nitric oxide biosynthetic process; wound healing; cellular response to stress; locomotory behavior; response to lipopolysaccharide; behavioral response to ethanol; sensory perception of pain; negative regulation of cell proliferation; synaptic transmission; elevation of cytosolic calcium ion concentration; neuropeptide signaling pathway; positive regulation of appetite; sensory perception; acute inflammatory response to antigenic stimulus; dopamine receptor, adenylate cyclase activating pathway; response to food; positive regulation of neurogenesis; negative regulation of nitric oxide biosynthetic process; negative regulation of adenylate cyclase activity; response to cocaine; G-protein signaling, coupled to cyclic nucleotide second messenger; reduction of cytosolic calcium ion concentration; opioid receptor, adenylate cyclase inhibiting pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of sensory perception of pain; regulation of excitatory postsynaptic membrane potential

Disease: Epilepsy, Idiopathic Generalized