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Wild Type (SUMO4) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS628954

SUMO4 is a member of the SUMO gene family. This family of small ubiquitin-related modifiers covalently modify target lysines in proteins and control the target proteins' subcellular localization, stability, or activity. Upon oxidative stress, SUMO4 conjugates… More details

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Product Overview

Online Datasheet in PDF
Product Name
SUMO4, wild type, Polyclonal Antibody
Full Product Name
SUMO4, wild type (M55) (Small Ubiquitin-related Modifier 4, Small Ubiquitin-like Protein 4, SUMO-4, SMT3H4)
Product Gene Name
anti-SUMO4 antibody
Product Synonym Names
Anti -SUMO4, wild type (M55) (Small Ubiquitin-related Modifier 4, Small Ubiquitin-like Protein 4, SUMO-4, SMT3H4)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human SUMO4.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
10,685 Da
Chromosome Location
Chromosome: 6; NC_000006.11 (149721495..149722182). Location: 6q25
OMIM
600320
3D Structure
ModBase 3D Structure for Q6EEV6
Immunogen
Synthetic peptide CEPRGLS(M)KQIRFRFG selected from human SUMO4 (KLH).

Product Categories/Family for anti-SUMO4 antibody

Antibodies; Abs to Ubiquitin
Applications Tested/Suitable for anti-SUMO4 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-SUMO4 antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100

Western Blot (WB) of anti-SUMO4 antibody

Western blot analysis of SUMO4 Antibody (M55 Wild type) in HepG2 cell line lysate (35ug/lane). SUMO4 wild type (arrow) was detected using the purified Pab.
Rabbit Anti-SUMO4 Polyclonal Antibody – Cat# MBS628954

Immunohistochemistry (IHC) of anti-SUMO4 antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with SUMO4 antibody (M55 Wild type) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-SUMO4 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS628954

Immunohistochemistry (IHC) of anti-SUMO4 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Rabbit Anti-SUMO4 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS628954

Other Notes

Small volumes of anti-SUMO4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SUMO4 purchase

MBS628954 is an antibody targeting SUMO4. Also known as SUMO4, wild type (M55) (Small Ubiquitin-related Modifier 4, Small Ubiquitin-like Protein 4, SUMO-4, SMT3H4). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SUMO4. It may not necessarily be applicable to this product.

NCBI GI #
50400081
NCBI GeneID
387082
NCBI Accession #
NP_001002255.1
UniProt Primary Accession #
Q6EEV6
UniProt Secondary Accession #
A1L3W5
UniProt Related Accession #
Q6EEV6
GenBank Nucleotide #
NM_001002255.1
NCBI Official Full Name
small ubiquitin-related modifier 4
NCBI Official Synonym Full Names
SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae)
NCBI Official Symbol
SUMO4
NCBI Official Synonym Symbols
IDDM5; SMT3H4; SUMO-4; dJ281H8.4
UniProt Protein Name
Small ubiquitin-related modifier 4
UniProt Synonym Protein Names
Small ubiquitin-like protein 4
Protein Family
Putative small ubiquitin-related modifier
UniProt Gene Name
SUMO4
UniProt Synonym Gene Names
SMT3H4
UniProt Entry Name
SUMO4_HUMAN
NCBI Protein Information
small ubiquitin-related modifier 4; OTTHUMP00000017390; SMT3 suppressor of mif two 3 homolog 2; small ubiquitin-like modifier 4 protein

NCBI Summary for SUMO4

This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism. [provided by RefSeq]
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UniProt Comments for SUMO4

SUMO4: Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. Belongs to the ubiquitin family. SUMO subfamily.

Protein type: Ubiquitin-like modifier

Chromosomal Location of Human Ortholog: 6q25

Cellular Component: nucleus

Biological Process: protein sumoylation

Disease: Diabetes Mellitus, Insulin-dependent, 5
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Research Articles on SUMO4

1. The SUMO4 gene single nucleotide polymorphism variant is not associated with susceptibility of the type 2 diabetes polymorphism.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SUMO4 antibody

 Reference Product  PubMed Publications
 FOS antibody  >2 publications with SUMO4 and FOS
 GAPDH antibody  >1 publications with SUMO4 and GAPDH

Pathways associated with anti-SUMO4 antibody

 Products by Pathway  Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram

Diseases associated with anti-SUMO4 antibody

 Disease Name  Pubmed Publications
 Diabetes Mellitus, Type 1 Antibodies  >27 publications with SUMO4 and Diabetes Mellitus, Type 1
 Inflammation Antibodies  >3 publications with SUMO4 and Inflammation
 Obesity Antibodies  >1 publications with SUMO4 and Obesity
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