• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

CTF1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6289758

The protein encoded by this gene is a secreted cytokine that induces cardiac myocyte hypertrophy in vitro. It has been shown to bind and activate the ILST/gp130 receoptor. Two transcript variants encoding different isoforms have been found for this gene. More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CTF1, Polyclonal Antibody
Full Product Name
CTF1, CT (CTF1, Cardiotrophin-1) (PE)
Product Gene Name
anti-CTF1 antibody
Product Synonym Names
CTF1; Cardiotrophin-1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
21,227 Da
Chromosome Location
Chromosome: 16; NC_000016.9 (30907928..30914881). Location: 16p11.2
OMIM
600435
3D Structure
ModBase 3D Structure for Q16619
Immunogen
CTF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 165-194 amino acids from the C-terminal region of human CTF1.
Conjugate
PE
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-CTF1 antibody

Antibodies; Cardiac Markers
Applications Tested/Suitable for anti-CTF1 antibody
Flow Cytometry (FC/FACS), FLISA, Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-CTF1 antibody
FC/FACS: 1:10-50
FLISA: 1:1,000
IHC: 1:10-50
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-CTF1 antibody

CTF1 Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the CTF1 antibody detected the CTF1 protein (arrow).
Rabbit Anti-CTF1 Polyclonal Antibody – Cat# MBS6289758

Flow Cytometry (FC/FACS) of anti-CTF1 antibody

CTF1 Antibody (C-term) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-CTF1 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6289758

Immunohistochemistry (IHC) of anti-CTF1 antibody

CTF1 Antibody (C-term) (AP14905b)immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CTF1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-CTF1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6289758

Product References and Citations for anti-CTF1 antibody

Robador, P.A., et al. J. Hypertens. (2010). In press: Bailey, S.D., et al. Diabetes Care (2010). In press: Limongelli, G., et al. Cytokine 50(3):245-247(2010). Zimmerman, R.S., et al. Genet. Med. 12(5):268-278(2010). Fritzenwanger, M., et al. Mediators Inflamm. 2009, 489802 (2009).

Other Notes

Small volumes of anti-CTF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CTF1 purchase

MBS6289758 is an antibody targeting CTF1. Also known as CTF1, CT (CTF1, Cardiotrophin-1) (PE). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CTF1. It may not necessarily be applicable to this product.

NCBI GI #
4503121
NCBI GeneID
1489
NCBI Accession #
NP_001321.1
NCBI Related Accession #
NP_001136016.1
UniProt Primary Accession #
Q16619
UniProt Secondary Accession #
Q5U5Y7; A8MVX4
UniProt Related Accession #
Q16619
GenBank Nucleotide #
NM_001330.3
NCBI Official Full Name
cardiotrophin-1 isoform 1
NCBI Official Synonym Full Names
cardiotrophin 1
NCBI Official Symbol
CTF1
NCBI Official Synonym Symbols
CT1; CT-1
UniProt Protein Name
Cardiotrophin-1
Protein Family
Cardiotrophin
UniProt Gene Name
CTF1
UniProt Synonym Gene Names
CT-1
UniProt Entry Name
CTF1_HUMAN
NCBI Protein Information
cardiotrophin-1; cardiophin 1

UniProt Comments for CTF1

CTF1: Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor. Belongs to the IL-6 superfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: extracellular space; extracellular region

Molecular Function: leukemia inhibitory factor receptor binding; cytokine activity

Biological Process: nervous system development; cell proliferation; muscle development; cell-cell signaling; leukemia inhibitory factor signaling pathway; positive regulation of cell proliferation; neuron development
Show more

Research Articles on CTF1

1. Cardiotrophin-1 may serve as both a biomarker of left ventricular hypertrophy and dysfunction in hypertensive patients, and is potential target for therapies aimed to prevent and treat hypertensive heart disease beyond blood pressure control.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CTF1 antibody

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 MicroRNAs In Cardiomyocyte Hypertrophy Pathway antibodies  MicroRNAs In Cardiomyocyte Hypertrophy Pathway Diagram

Diseases associated with anti-CTF1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >8 publications with CTF1 and Neoplasms
 Neoplasms, Experimental Antibodies  >3 publications with CTF1 and Neoplasms, Experimental
 Neovascularization, Pathologic Antibodies  >1 publications with CTF1 and Neovascularization, Pathologic
 Hypertrophy Antibodies  >1 publications with CTF1 and Hypertrophy
 Reperfusion Injury Antibodies  >1 publications with CTF1 and Reperfusion Injury
 Acute Kidney Injury Antibodies  >1 publications with CTF1 and Acute Kidney Injury
 Heart Diseases Antibodies  >1 publications with CTF1 and Heart Diseases
 Inflammation Antibodies  >1 publications with CTF1 and Inflammation
 Ischemia Antibodies  >1 publications with CTF1 and Ischemia
 Necrosis Antibodies  >1 publications with CTF1 and Necrosis

Organs/Tissues associated with anti-CTF1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with CTF1 and Brain
 Nerve Antibodies  >1 publications with CTF1 and Nerve
 Lung Antibodies  >1 publications with CTF1 and Lung
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000