Zinc Transporter ZIP2 (SLC39A2) Antibody – Rabbit Polyclonal

Zinc is an essential nutrient for all organisms because of the many important roles this metal plays. Movement of zinc into and out of cells and subcellular organelles is mediated by zinc transporter proteins. In many organisms, zinc uptake is mediated by members of the ZIP family of metal ion transporters. In mammals, the Zip1, Zip2, Zip3, Zip4, Zip5, LIV- 1 (Zip6), KE4 (Zip7), and BIGM103 (Zip8) proteins have been implicated in zinc uptake in a variety of cell and tissue types.

ZIP2 (SLC39A2; Eti-1; 6A1) encodes a protein of 309aa, includes an amino terminal signal peptide of 26aa, and has the predicted topology of Zip proteins. The human or mouse Zip2 overexpression in transfected K562 and human embryonic kidney (HEK293) cells, respectively, increased 65Zn uptake in these cells. hZIP2-induced Zn uptake was shown to be highly inhibited by Mn2+ and Co2+, metals that did not substantially affect hZIP1-, mZIP1-, or mZIP2-induced Zn uptake. Zn uptake mediated by hZIP2 appears to be stimulated by HCO 3, non-ATP dependent, but sensitive to N-ethylmaleimide, a sulfhydryl-reactive agent.

Small volumes of anti-SLC39A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS629062 is an antibody targeting SLC39A2. Also known as Anti-Zinc Transporter ZIP2 (Solute Carrier Family 39 Member 2, Zrt- and Irt-like Protein 2, ZIP-2, hZIP2, SLC39A2, 6A1, Eti-1, ZIP2). Reactive in Mouse. Host: Rabbit.