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MAGEA1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS629135

MAGEA1 is a member of the MAGEA gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 80% sequence identity between each other. The promoters and first exons of the MAGEA genes… More details

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Product Overview

Online Datasheet in PDF
Product Name
MAGEA1, Polyclonal Antibody
Full Product Name
MAGEA1, ID (Melanoma-associated Antigen 1, MAGE-1 Antigen, Antigen MZ2-E, Cancer/Testis Antigen 1.1, CT1.1, MAGE1, MAGE1A)
Product Gene Name
anti-MAGEA1 antibody
Product Synonym Names
Anti -MAGEA1, ID (Melanoma-associated Antigen 1, MAGE-1 Antigen, Antigen MZ2-E, Cancer/Testis Antigen 1.1, CT1.1, MAGE1, MAGE1A)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human MAGEA1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
34,342 Da
Chromosome Location
Chromosome: X; NC_000023.10 (152481522..152486116, complement). Location: Xq28
OMIM
300016
3D Structure
ModBase 3D Structure for P43355
Immunogen
Synthetic peptide selected from the center region of human MAGEA1 (KLH).

Product Categories/Family for anti-MAGEA1 antibody

Antibodies; Abs to Cancer Markers
Applications Tested/Suitable for anti-MAGEA1 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-MAGEA1 antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100

Western Blot (WB) of anti-MAGEA1 antibody

Western blot analysis of anti-MAGEA1 Antibody (Center) (RB02082) in Hela cell line lysates (35ug/lane). MAGEA1(arrow) was detected using the purified Pab.
Rabbit Anti-MAGEA1 Polyclonal Antibody – Cat# MBS629135

Immunohistochemistry (IHC) of anti-MAGEA1 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Rabbit Anti-MAGEA1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS629135

Immunohistochemistry (IHC) of anti-MAGEA1 antibody

Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with MAGEA1 Antibody (Center) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-MAGEA1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS629135

Other Notes

Small volumes of anti-MAGEA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MAGEA1 purchase

MBS629135 is an antibody targeting MAGEA1. Also known as MAGEA1, ID (Melanoma-associated Antigen 1, MAGE-1 Antigen, Antigen MZ2-E, Cancer/Testis Antigen 1.1, CT1.1, MAGE1, MAGE1A). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MAGEA1. It may not necessarily be applicable to this product.

NCBI GI #
148276977
NCBI GeneID
4100
NCBI Accession #
NP_004979.3
UniProt Primary Accession #
P43355
UniProt Secondary Accession #
O00346; B2RC81
UniProt Related Accession #
P43355; Q8WX99; AAB33086
GenBank Nucleotide #
NM_004988.4
NCBI Official Full Name
melanoma-associated antigen 1
NCBI Official Synonym Full Names
melanoma antigen family A, 1 (directs expression of antigen MZ2-E)
NCBI Official Symbol
MAGEA1
NCBI Official Synonym Symbols
CT1.1; MAGE1; MGC9326
UniProt Protein Name
Melanoma-associated antigen 1
UniProt Synonym Protein Names
Antigen MZ2-E; Cancer/testis antigen 1.1; CT1.1; MAGE-1 antigen
Protein Family
Melanoma-associated antigen
UniProt Gene Name
MAGEA1
UniProt Synonym Gene Names
MAGE1; MAGE1A
UniProt Entry Name
MAGA1_HUMAN
NCBI Protein Information
melanoma-associated antigen 1; antigen MZ2-E; MAGE-1 antigen; OTTHUMP00000025911; melanoma antigen MAGE-1; cancer/testis antigen 1.1; melanoma antigen family A 1; melanoma-associated antigen MZ2-E; cancer/testis antigen family 1, member 1

NCBI Summary for MAGEA1

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq]
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UniProt Comments for MAGEA1

MAGE-A1: a tumor antigen expressed in a variety of tumor cells and in the testis. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.

Protein type: Cell surface

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: cytoplasm; plasma membrane; nucleus

Molecular Function: protein binding; histone deacetylase binding

Biological Process: transcription, DNA-dependent; negative regulation of Notch signaling pathway; negative regulation of transcription from RNA polymerase II promoter
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Research Articles on MAGEA1

1. High MAGE-1 is associated with differentiated advanced gastric cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MAGEA1 antibody

 Reference Product  PubMed Publications
 HLA-A antibody  >40 publications with MAGEA1 and HLA-A
 HLA-B antibody  >8 publications with MAGEA1 and HLA-B

Pathways associated with anti-MAGEA1 antibody

 Products by Pathway  Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram

Diseases associated with anti-MAGEA1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >241 publications with MAGEA1 and Neoplasms
 Melanoma Antibodies  >149 publications with MAGEA1 and Melanoma
 Head and Neck Neoplasms Antibodies  >19 publications with MAGEA1 and Head and Neck Neoplasms
 Stomach Neoplasms Antibodies  >17 publications with MAGEA1 and Stomach Neoplasms
 Carcinoma, Squamous Cell Antibodies  >14 publications with MAGEA1 and Carcinoma, Squamous Cell
 Endocrine Gland Neoplasms Antibodies  >14 publications with MAGEA1 and Endocrine Gland Neoplasms
 Breast Neoplasms Antibodies  >13 publications with MAGEA1 and Breast Neoplasms
 Leukemia Antibodies  >11 publications with MAGEA1 and Leukemia
 Colorectal Neoplasms Antibodies  >9 publications with MAGEA1 and Colorectal Neoplasms
 Ovarian Neoplasms Antibodies  >6 publications with MAGEA1 and Ovarian Neoplasms

Organs/Tissues associated with anti-MAGEA1 antibody

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >68 publications with MAGEA1 and Testis
 Lung Antibodies  >22 publications with MAGEA1 and Lung
 Skin Antibodies  >18 publications with MAGEA1 and Skin
 Bone Antibodies  >11 publications with MAGEA1 and Bone
 Ovary Antibodies  >3 publications with MAGEA1 and Ovary
 Connective Tissue Antibodies  >1 publications with MAGEA1 and Connective Tissue
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