IRS-2 (IRS2) Antibody – Rabbit Polyclonal

Insulin receptor substrate (IRS) proteins play a pivotal role in signal transduction by the receptors for insulin, insulin-like growth factor 1 (IGF-1), and a growing number of cytokines and integrins. Four IRS proteins (IRS-1, IRS-2, IRS-3 and IRS-4) have beenidentified and characterized. Recently, two more signaling proteins, IRS5/DOK4 and IRS6/DOK5, have been identified as potentially new members of the IRS family. IRSs are tyrosine-phosphorylated following insulin or IGF-1 stimulation and form signaling complexes at the receptor with Src homology 2 domain-containing proteins, including the p85 regulatory subunit of phosphatidylinositol 3-kinase, Grb2, Nck, and Shc. IRS family of proteins share a number of structural and functional characteristics, including an N-terminal pleckstrin homology (PH) and a phosphotyrosine binding domain (PTB), followed by a large C-terminal region containing multiple sites of tyrosine phosphorylation, which serve as docking sites for Src homology 2 domain-containing signaling proteins. Despite the overall similarity, the IRS proteins differin their subcellular distribution and tissue/developmental expression pattern. Each IRS is phosphorylated on a set of specific tyrosine residues, leading to its binding to the Src homology 2 domains of distinct signaling proteinsand therefore, activation of specific tyrosine residues, leading to its binding to the Src homology 2 domains of distinct signaling proteins and therefore, activation of specific signaling cascades. Disruption of each individual IRS gene causes distinct phenotypes in mice, further indicating that the four IRS proteins play different roles in the regulation of the pleiotropic effects of insulin, IGF-1, and other growth factors.

Small volumes of anti-IRS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS629200 is an antibody targeting IRS2. Also known as Anti-IRS-2 (Insulin Receptor Substrate 2). Reactive in Human; Mouse; Rat. Host: Rabbit.