Rabbit Anti-DLEC1 Polyclonal Antibody – Cat# MBS6292299

DLEC1 Antibody (Center) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the DLEC1 antibody detected the DLEC1 protein (arrow).

DLEC1 Antibody – Rabbit Polyclonal

Name: DLEC1 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6292299
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6292299

This gene contains 37 exons, spans approximately 59-kb, and is located in the 3p22-p21.3 chromosomal segment that is commonly deleted in various carcinomas. Several alternatively spliced transcripts have been observed that contain disrupted coding regions and… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

DLEC1, Polyclonal Antibody

Full Product Name

DLEC1, ID (DLEC1, DLC1, Deleted in lung and esophageal cancer protein 1, Deleted in lung cancer protein 1) (PE)

Product Gene Name

anti-DLEC1 antibody

Product Synonym Names

DLEC1; DLC1; Deleted in lung and esophageal cancer protein 1; Deleted in lung cancer protein 1

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

197,898 Da

OMIM

133239

3D Structure

ModBase 3D Structure for Q9Y238

Immunogen

DLEC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 878-908 amino acids from the Central region of human DLEC1.

Conjugate

Note

Preservative Free

Special Handling

Light sensitive

Product Categories/Family for anti-DLEC1 antibody

Antibodies; Cancer Markers

Applications Tested/Suitable for anti-DLEC1 antibody

Western Blot (WB), FLISA

Application Notes for anti-DLEC1 antibody

WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-DLEC1 antibody

Zhang, Q., et al. J. Urol. 184(2):731-737(2010). Zhang, Y., et al. Clin Lung Cancer 11(4):264-270(2010). Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Al Sarakbi, W., et al. Anticancer Res. 30(4):1079-1082(2010). Canova, C., et al. Cancer Res. 69(7):2956-2965(2009).

Other Notes

Small volumes of anti-DLEC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DLEC1 purchase

MBS6292299 is an antibody targeting DLEC1. Also known as DLEC1, ID (DLEC1, DLC1, Deleted in lung and esophageal cancer protein 1, Deleted in lung cancer protein 1) (PE). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DLEC1. It may not necessarily be applicable to this product.

NCBI GI #

90669194

NCBI GeneID

9940

NCBI Accession #

NP_031361

UniProt Primary Accession #

Q9Y238

UniProt Secondary Accession #

Q9NSW0; Q9NTG5

UniProt Related Accession #

Q9Y238

GenBank Nucleotide #

NM_007335.3

NCBI Official Full Name

deleted in lung and esophageal cancer protein 1 isoform DLEC1-N1

NCBI Official Synonym Full Names

deleted in lung and esophageal cancer 1

NCBI Official Symbol

DLEC1

NCBI Official Synonym Symbols

F56; DLC1; DLC-1; CFAP81

UniProt Protein Name

Deleted in lung and esophageal cancer protein 1

UniProt Synonym Protein Names

Deleted in lung cancer protein 1

Protein Family

Deleted in lung and esophageal cancer protein

UniProt Gene Name

DLEC1

UniProt Synonym Gene Names

DLC1; DLC-1

UniProt Entry Name

DLEC1_HUMAN

NCBI Protein Information

deleted in lung and esophageal cancer protein 1

NCBI Summary for DLEC1

The cytogenetic location of this gene is 3p21.3, and it is located in a region that is commonly deleted in a variety of malignancies. Down-regulation of this gene has been observed in several human cancers including lung, esophageal, renal tumors, and head and neck squamous cell carcinoma. In some cases, reduced expression of this gene in tumor cells is a result of aberrant promoter methylation. Several alternatively spliced transcripts have been observed that contain disrupted coding regions and likely encode nonfunctional proteins.[provided by RefSeq, Mar 2016]

UniProt Comments for DLEC1

DLEC1: May act as a tumor suppressor by inhibiting cell proliferation. DLEC1 silencing due to promoter methylation and aberrant transcription are implicated in the development of different cancers, including esophageal (ESCR), renal and lung cancers (LNCR). Defects in DLEC1 are a cause of lung cancer (LNCR). A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis. DLEC1 silencing due to promoter methylation and aberrant transcription are implicated in the development of lung cancer. Defects in DLEC1 are a cause of esophageal cancer (ESCR). A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage. DLEC1 silencing due to promoter methylation and aberrant transcription are implicated in the development of esophageal cancer. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Tumor suppressor

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: cytoplasm

Biological Process: negative regulation of cell proliferation

Disease: Lung Cancer; Esophageal Cancer

Research Articles on DLEC1

1. the expression levels of DLEC1 and ITGA9 were prominently decreased in lung tumor samples

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-DLEC1 antibody

Disease Name	Pubmed Publications
Lung Neoplasms Antibodies	>13 publications with DLEC1 and Lung Neoplasms
Esophageal Neoplasms Antibodies	>6 publications with DLEC1 and Esophageal Neoplasms

Organs/Tissues associated with anti-DLEC1 antibody

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>17 publications with DLEC1 and Lung
Stomach Antibodies	>3 publications with DLEC1 and Stomach
Uterus Antibodies	>1 publications with DLEC1 and Uterus