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DNAJC5 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6292860

This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. The encoded protein plays a role in membrane trafficking and protein folding, and has been shown to… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DNAJC5, Polyclonal Antibody
Full Product Name
DNAJC5, ID (DNAJC5, CSP, DnaJ homolog subfamily C member 5, Cysteine string protein) (PE)
Product Gene Name
anti-DNAJC5 antibody
Product Synonym Names
DNAJC5; CSP; DnaJ homolog subfamily C member 5; Cysteine string protein
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
22,149 Da
Chromosome Location
Chromosome: 20; NC_000020.10 (62526455..62567384). Location: 20q13.33
OMIM
162350
3D Structure
ModBase 3D Structure for Q9H3Z4
Immunogen
DNAJC5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51-80 amino acids from the Central region of human DNAJC5.
Conjugate
PE
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-DNAJC5 antibody

Antibodies; Amino Acids
Applications Tested/Suitable for anti-DNAJC5 antibody
Western Blot (WB), FLISA
Application Notes for anti-DNAJC5 antibody
WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-DNAJC5 antibody

DNAJC5 Antibody (Center) western blot analysis in Y79 cell line lysates (35ug/lane).This demonstrates the DNAJC5 antibody detected the DNAJC5 protein (arrow).
Rabbit Anti-DNAJC5 Polyclonal Antibody – Cat# MBS6292860

Western Blot (WB) of anti-DNAJC5 antibody

DNAJC5 Antibody (Center) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the DNAJC5 antibody detected the DNAJC5 protein (arrow).
Rabbit Anti-DNAJC5 Polyclonal Antibody, Western Blot (WB) – Cat# MBS6292860

Product References and Citations for anti-DNAJC5 antibody

Johnson, J.N., et al. Biochem. Cell Biol. 88(2):157-165(2010). Schmidt, B.Z., et al. J. Biol. Chem. 284(7):4168-4178(2009). Greaves, J., et al. J. Biol. Chem. 283(36):25014-25026(2008). Park, J., et al. Am. J. Respir. Cell Mol. Biol. 39(1):68-76(2008). Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007).

Other Notes

Small volumes of anti-DNAJC5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DNAJC5 purchase

MBS6292860 is an antibody targeting DNAJC5. Also known as DNAJC5, ID (DNAJC5, CSP, DnaJ homolog subfamily C member 5, Cysteine string protein) (PE). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DNAJC5. It may not necessarily be applicable to this product.

NCBI GI #
45504382
NCBI GeneID
80331
NCBI Accession #
NP_079495.1
UniProt Primary Accession #
Q9H3Z4
UniProt Secondary Accession #
Q9H3Z5; Q9H7H2; A8K0M0; B3KY68; E1P5G8
UniProt Related Accession #
Q9H3Z4
GenBank Nucleotide #
NM_025219.2
NCBI Official Full Name
dnaJ homolog subfamily C member 5
NCBI Official Synonym Full Names
DnaJ (Hsp40) homolog, subfamily C, member 5
NCBI Official Symbol
DNAJC5
NCBI Official Synonym Symbols
CSP; NCL; CLN4; CLN4B; DNAJC5A
UniProt Protein Name
DnaJ homolog subfamily C member 5
UniProt Synonym Protein Names
Cysteine string protein
Protein Family
DnaJ homolog subfamily
UniProt Gene Name
DNAJC5
UniProt Synonym Gene Names
CSP; CSP
UniProt Entry Name
DNJC5_HUMAN
NCBI Protein Information
dnaJ homolog subfamily C member 5; cysteine string protein alpha

UniProt Comments for DNAJC5

DNAJC5: a cysteine string protein that inhibits N-type calcium channels which is blocked by huntingtin mutants. May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings. Modulates the maturation of cystic fibrosis transmembrane conductance regulator. Two splice-variant isoforms have been described.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 20q13.33

Cellular Component: synaptic vesicle; membrane; mitochondrion; lysosomal membrane; plasma membrane; melanosome

Molecular Function: ATP-dependent protein binding; glycoprotein binding

Biological Process: regulated secretory pathway; synaptic transmission; synaptic vesicle exocytosis; exocytosis; neurotransmitter secretion; negative regulation of neuron apoptosis
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Research Articles on DNAJC5

1. Palmitoylation-induced aggregation of mutant CSP-alpha proteins may underlie the development of adult-onset neuronal ceroid lipofuscinosis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-DNAJC5 antibody

 Products by Pathway  Pathway Diagram
 GABA Synthesis, Release, Reuptake And Degradation Pathway antibodies  GABA Synthesis, Release, Reuptake And Degradation Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Neurotransmitter Release Cycle Pathway antibodies  Neurotransmitter Release Cycle Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Transmission Across Chemical Synapses Pathway antibodies  Transmission Across Chemical Synapses Pathway Diagram

Diseases associated with anti-DNAJC5 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >5 publications with DNAJC5 and Nervous System Diseases
 Brain Diseases Antibodies  >2 publications with DNAJC5 and Brain Diseases
 Seizures Antibodies  >2 publications with DNAJC5 and Seizures
 Central Nervous System Diseases Antibodies  >1 publications with DNAJC5 and Central Nervous System Diseases
 Epilepsy, Tonic-Clonic Antibodies  >1 publications with DNAJC5 and Epilepsy, Tonic-Clonic
 Cognition Disorders Antibodies  >1 publications with DNAJC5 and Cognition Disorders

Organs/Tissues associated with anti-DNAJC5 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >6 publications with DNAJC5 and Brain
 Nerve Antibodies  >2 publications with DNAJC5 and Nerve
 Muscle Antibodies  >1 publications with DNAJC5 and Muscle
 Skin Antibodies  >1 publications with DNAJC5 and Skin
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