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PRDX2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS629297

PRDX2 is a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. This protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This… More details

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Product Overview

Online Datasheet in PDF
Product Name
PRDX2, Polyclonal Antibody
Full Product Name
PRDX2, CT (Peroxiredoxin-2, Thioredoxin Peroxidase 1, Thioredoxin-dependent Peroxide Reductase 1, Thiol-specific Antioxidant Protein, TSA, PRP, Natural Killer Cell-enhancing Factor B, NKEF-B, TDPX1, NKEFB)
Product Gene Name
anti-PRDX2 antibody
Product Synonym Names
Anti -PRDX2, CT (Peroxiredoxin-2, Thioredoxin Peroxidase 1, Thioredoxin-dependent Peroxide Reductase 1, Thiol-specific Antioxidant Protein, TSA, PRP, Natural Killer Cell-enhancing Factor B, NKEF-B, TDPX1, NKEFB)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, 0.114% sodium azide.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human PRDX2. Species Crossreactivity: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
21,892 Da
Chromosome Location
Chromosome: 19; NC_000019.9 (12907634..12912694, complement). Location: 19p13.2
OMIM
600538
3D Structure
ModBase 3D Structure for P32119
Immunogen
Synthetic peptide selected from the C-terminal region of human PRDX2 (KLH).

Product Categories/Family for anti-PRDX2 antibody

Antibodies; Abs to Enzymes; Peroxiredoxin
Applications Tested/Suitable for anti-PRDX2 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-PRDX2 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100

Immunofluorescence (IF) of anti-PRDX2 antibody

Fluorescent confocal image of Hela cell stained with PRDX2 Antibody (C-term).Hela cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with PRDX2 primary antibody (1:25, 1 h at 37℃). For secondary antibody, Alexa Fluor® 488 conjugated donkey anti-rabbit antibody (green) was used (1:400, 50 min at 37℃).Cytoplasmic actin was counterstained with Alexa Fluor® 555 (red) conjugated Phalloidin (7units/ml, 1 h at 37℃). Nuclei were counterstained with DAPI (blue) (10 µg/ml, 10 min).PRDX2 immunoreactivity is localized to Cytoplasm significantly.
Rabbit Anti-PRDX2 Polyclonal Antibody – Cat# MBS629297

Western Blot (WB) of anti-PRDX2 antibody

Western blot analysis of PRDX2 Antibody (C-term) in MDA-MB231,293 cell line and mouse brain tissue lysates (35ug/lane).PRDX2 (arrow) was detected using the purified Pab.(2ug/ml)
Rabbit Anti-PRDX2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS629297

Immunohistochemistry (IHC) of anti-PRDX2 antibody

Formalin-fixed and paraffin-embedded human brain tissue reacted with PRDX2 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-PRDX2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS629297

Other Notes

Small volumes of anti-PRDX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PRDX2 purchase

MBS629297 is an antibody targeting PRDX2. Also known as PRDX2, CT (Peroxiredoxin-2, Thioredoxin Peroxidase 1, Thioredoxin-dependent Peroxide Reductase 1, Thiol-specific Antioxidant Protein, TSA, PRP, Natural Killer Cell-enhancing Factor B, NKEF-B, TDPX1, NKEFB). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PRDX2. It may not necessarily be applicable to this product.

NCBI GI #
33188454
NCBI GeneID
7001
NCBI Accession #
NP_859428.1
UniProt Primary Accession #
P32119
UniProt Secondary Accession #
P31945; P32118; P35701; Q6FHG4; Q92763; Q9UC23
UniProt Related Accession #
P32119
GenBank Nucleotide #
NM_181738.1
NCBI Official Full Name
peroxiredoxin-2 isoform c
NCBI Official Synonym Full Names
peroxiredoxin 2
NCBI Official Symbol
PRDX2
NCBI Official Synonym Symbols
PRP; TSA; PRX2; TPX1; NKEFB; PRXII; TDPX1; MGC4104
UniProt Protein Name
Peroxiredoxin-2
UniProt Synonym Protein Names
Natural killer cell-enhancing factor B; NKEF-B; PRP; Thiol-specific antioxidant protein; TSA; Thioredoxin peroxidase 1; Thioredoxin-dependent peroxide reductase 1
Protein Family
Peroxiredoxin
UniProt Gene Name
PRDX2
UniProt Synonym Gene Names
NKEFB; TDPX1
UniProt Entry Name
PRDX2_HUMAN
NCBI Protein Information
peroxiredoxin-2; torin; NKEF-B; OTTHUMP00000165823; OTTHUMP00000165825; thioredoxin peroxidase 1; thiol-specific antioxidant 1; natural killer-enhancing factor B; thiol-specific antioxidant protein; natural killer cell-enhancing factor B; thioredoxin-dependent peroxide reductase 1

NCBI Summary for PRDX2

This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. The crystal structure of this protein has been resolved to 2.7 angstroms. Transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq]
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UniProt Comments for PRDX2

PRDX2: a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). May have a proliferative effect and play a role in cancer development or progression. Three splice-variant isoforms have been identified.

Protein type: EC 1.11.1.15; Oxidoreductase

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: cytoplasm; cytosol

Molecular Function: antioxidant activity; thioredoxin peroxidase activity

Biological Process: regulation of apoptosis; response to reactive oxygen species; removal of superoxide radicals; hydrogen peroxide catabolic process; response to oxidative stress; negative regulation of neuron apoptosis; negative regulation of apoptosis
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Research Articles on PRDX2

1. PRDX2 was up-regulated in women older than 38 years, and its expression in cumulus cells was associated with embryo quality

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PRDX2 antibody

 Products by Pathway  Pathway Diagram
 Selenium Pathway antibodies  Selenium Pathway Diagram

Diseases associated with anti-PRDX2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >24 publications with PRDX2 and Neoplasms
 Carcinoma Antibodies  >11 publications with PRDX2 and Carcinoma
 Death Antibodies  >6 publications with PRDX2 and Death
 Drug Toxicity Antibodies  >5 publications with PRDX2 and Drug Toxicity
 Adenocarcinoma Antibodies  >5 publications with PRDX2 and Adenocarcinoma
 Anemia Antibodies  >4 publications with PRDX2 and Anemia
 Neoplasms, Experimental Antibodies  >4 publications with PRDX2 and Neoplasms, Experimental
 Anemia, Hemolytic Antibodies  >4 publications with PRDX2 and Anemia, Hemolytic
 Genital Neoplasms, Female Antibodies  >4 publications with PRDX2 and Genital Neoplasms, Female
 Neurodegenerative Diseases Antibodies  >4 publications with PRDX2 and Neurodegenerative Diseases

Organs/Tissues associated with anti-PRDX2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >31 publications with PRDX2 and Blood
 Vascular Antibodies  >9 publications with PRDX2 and Vascular
 Brain Antibodies  >9 publications with PRDX2 and Brain
 Muscle Antibodies  >8 publications with PRDX2 and Muscle
 Liver Antibodies  >8 publications with PRDX2 and Liver
 Kidney Antibodies  >6 publications with PRDX2 and Kidney
 Eye Antibodies  >4 publications with PRDX2 and Eye
 Heart Antibodies  >4 publications with PRDX2 and Heart
 Ovary Antibodies  >3 publications with PRDX2 and Ovary
 Lung Antibodies  >3 publications with PRDX2 and Lung
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