Rabbit Anti-NELL2 Polyclonal Antibody – Cat# MBS629307

Protein Kinase C, Mu, Protein Kinase D (NELL2) Antibody – Rabbit Polyclonal

Name: NELL2 Antibody; Polyclonal; Rabbit; Human/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS629307
Price: 765 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS629307

Protein Kinase Cm (PKCm), is a ~140kD member of the novel group (nPKCs: sensitive to diacylglycerol, phosphatidylserine and phorbol esters) of the PKC family of serine/threonine kinases that are involved in a wide range of physiological processes including… More details

$765 / 10 Blots +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Protein Kinase C, mu, Protein Kinase D (Nell2), Polyclonal Antibody

Full Product Name

Protein Kinase C, mu, Protein Kinase D, phosphorylated (Ser742) (PKCm, PKD)

Product Gene Name

anti-Nell2 antibody

Product Synonym Names

Anti -Protein Kinase C, mu, Protein Kinase D, phosphorylated (Ser742) (PKCm, PKD)

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human, Mouse

Form/Format

Supplied as a liquid in PBS (without Mg2+ and Ca2+), 1mg/ml BSA (IgG, protease free), pH 7.2, 0.05% sodium azide, 50% glycerol.

Purity/Purification

Affinity Purified
Purified by immunoaffinity chromatography.

Specificity

Recognizes human and mouse PKCm/PKD when phosphorylated at Ser742. Does not cross react with PKCa [pT497], b I&II [pT500], g [pT514], d [pT507], e [pT566], i [pT403], h [pT512], th [pT538], or z [pT410] as determined by peptide competition experiments.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

91,432 Da

Chromosome Location

Chromosome: 15; NC_000081.6 (95219450..95528706, complement). Location: 15 F1; 15

3D Structure

ModBase 3D Structure for Q61220

Immunogen

Synthetic phosphopeptide derived from a region of human PKCm/PKD that contains serine 742. Species sequence homology: mouse.

Positive Control

K562 cells treated with PMA, or NIH3T3 cells treated with PDGF

Product Categories/Family for anti-Nell2 antibody

Antibodies; Abs to Protein Kinases

Applications Tested/Suitable for anti-Nell2 antibody

Western Blot (WB)

Application Notes for anti-Nell2 antibody

Suitable for use in Western Blot.
Dilution: Western Blot: 1:1000

Other Notes

Small volumes of anti-Nell2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Nell2 purchase

MBS629307 is an antibody targeting Nell2. Also known as Protein Kinase C, mu, Protein Kinase D, phosphorylated (Ser742) (PKCm, PKD). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Nell2. It may not necessarily be applicable to this product.

NCBI GI #

133922561

NCBI GeneID

54003

NCBI Accession #

NP_058023.2

UniProt Primary Accession #

Q61220

UniProt Secondary Accession #

Q80UM5

UniProt Related Accession #

Q61220

GenBank Nucleotide #

NM_016743.2

NCBI Official Full Name

protein kinase C-binding protein NELL2

NCBI Official Synonym Full Names

NEL-like 2

NCBI Official Symbol

Nell2

NCBI Official Synonym Symbols

mel91; R75516; A330108N19Rik

UniProt Protein Name

Protein kinase C-binding protein NELL2

UniProt Synonym Protein Names

MEL91 protein; NEL-like protein 2

Protein Family

Protein kinase C-binding protein

UniProt Gene Name

Nell2

UniProt Synonym Gene Names

Mel91

UniProt Entry Name

NELL2_MOUSE

NCBI Protein Information

protein kinase C-binding protein NELL2; NEL-like protein 2; nel-like 2 homolog

UniProt Comments for Nell2

NELL2: is a glycoprotein containing several von Willebrand factor C domains and epidermal growth factor (EGF)-like domains. The encoded protein acts as a homotrimer and is found in the cytoplasm. Several variants encoding a few different isoforms exist, and at least one isoform appears to be a secreted protein. Studies in mouse suggest that this protein plays a role in neural cell growth and differentiation as well as in oncogenesis. [provided by RefSeq, Feb 2009]

Protein type: Secreted; Secreted, signal peptide

Cellular Component: extracellular space; membrane; cytoplasm; dendrite; extracellular region; perikaryon

Molecular Function: heparin binding; identical protein binding; protein kinase C binding; calcium ion binding

Biological Process: regulation of growth; positive regulation of hormone secretion; development of secondary female sexual characteristics

Research Articles on Nell2

1. Nel interacts with a range of molecules through its different domains and exerts distinct functions.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-Nell2 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>7 publications with Nell2 and Neoplasms
Nervous System Diseases Antibodies	>3 publications with Nell2 and Nervous System Diseases
Kidney Diseases Antibodies	>2 publications with Nell2 and Kidney Diseases
Hyperplasia Antibodies	>2 publications with Nell2 and Hyperplasia
Skin Diseases Antibodies	>1 publications with Nell2 and Skin Diseases
Glioblastoma Antibodies	>1 publications with Nell2 and Glioblastoma
Prostatic Neoplasms Antibodies	>1 publications with Nell2 and Prostatic Neoplasms
Edema Antibodies	>1 publications with Nell2 and Edema
Neoplasms, Experimental Antibodies	>1 publications with Nell2 and Neoplasms, Experimental
Necrosis Antibodies	>1 publications with Nell2 and Necrosis

Organs/Tissues associated with anti-Nell2 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>19 publications with Nell2 and Brain
Embryonic Tissue Antibodies	>9 publications with Nell2 and Embryonic Tissue
Prostate Antibodies	>2 publications with Nell2 and Prostate
Testis Antibodies	>1 publications with Nell2 and Testis
Dorsal Root Ganglion Antibodies	>1 publications with Nell2 and Dorsal Root Ganglion
Spinal Cord Antibodies	>1 publications with Nell2 and Spinal Cord
Eye Antibodies	>1 publications with Nell2 and Eye