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DSCR1L1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6293561

DSCR1L1 inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. This protein may play a role during central nervous system development. Expression is detected in fibroblasts, heart, brain, liver, and… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
DSCR1L1, Polyclonal Antibody
Full Product Name
DSCR1L1, NT (RCAN2, DSCR1L1, ZAKI4, Calcipressin-2, Down syndrome candidate region 1-like 1, Myocyte-enriched calcineurin-interacting protein 2, Regulator of calcineurin 2, Thyroid hormone-responsive protein ZAKI-4) (MaxLight 550)
Product Gene Name
Product Synonym Gene Name
RCAN2
Product Synonym Names
RCAN2; DSCR1L1; ZAKI4; Calcipressin-2; Down syndrome candidate region 1-like 1; Myocyte-enriched calcineurin-interacting protein 2; Regulator of calcineurin 2; Thyroid hormone-responsive protein ZAKI-4
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
27,289 Da
OMIM
604876
3D Structure
ModBase 3D Structure for Q14206
Immunogen
DSCR1L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14~44 amino acids from the N-terminal region of human DSCR1L1.
Conjugate
MaxLight550
Note
Preservative Free

Product Categories/Family for anti-DSCR1L1 antibody

Applications Tested/Suitable for anti-DSCR1L1 antibody
Flow Cytometry (FC/FACS), FLISA, Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-DSCR1L1 antibody
FC/FACS: 1:10-50
FLISA: 1:1,000
IHC: 1:10-50
WB: 1:100-500
Applications are based on unconjugated antibody.

Product References and Citations for anti-DSCR1L1 antibody

Rothermel, B., et al., J. Biol. Chem. 275(12):8719-8725 (2000). Fuentes, J.J., et al., Hum. Mol. Genet. 9(11):1681-1690 (2000). Strippoli, P., et al., Genomics 64(3):252-263 (2000). Miyazaki, T., et al., J. Biol. Chem. 271(24):14567-14571 (1996). Cao, X., et al., Biochem. J. 367 (PT 2), 459-466 (2002). (): ().

Other Notes

Small volumes of anti-DSCR1L1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DSCR1L1 purchase

MBS6293561 is an antibody targeting DSCR1L1. Also known as DSCR1L1, NT (RCAN2, DSCR1L1, ZAKI4, Calcipressin-2, Down syndrome candidate region 1-like 1, Myocyte-enriched calcineurin-interacting protein 2, Regulator of calcineurin 2, Thyroid hormone-responsive protein ZAKI-4) (MaxLight 550). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DSCR1L1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
calcipressin-2 isoform 2
NCBI Official Synonym Full Names
regulator of calcineurin 2
NCBI Official Symbol
RCAN2
NCBI Official Synonym Symbols
CSP2; RCN2; MCIP2; ZAKI4; ZAKI-4; DSCR1L1
UniProt Protein Name
Calcipressin-2
UniProt Synonym Protein Names
Down syndrome candidate region 1-like 1; Myocyte-enriched calcineurin-interacting protein 2; MCIP2; Regulator of calcineurin 2; Thyroid hormone-responsive protein ZAKI-4
UniProt Gene Name
RCAN2
UniProt Synonym Gene Names
DSCR1L1; ZAKI4; MCIP2
UniProt Entry Name
RCAN2_HUMAN
NCBI Protein Information
calcipressin-2; Down syndrome candidate region 1-like 1; Down syndrome critical region gene 1-like 1; myocyte-enriched calcineurin-interacting protein 2; thyroid hormone-responsive (skin fibroblasts); thyroid hormone-responsive protein ZAKI-4

NCBI Summary for DSCR1L1

This gene encodes a member of the regulator of calcineurin (RCAN) protein family. These proteins play a role in many physiological processes by binding to the catalytic domain of calcineurin A, inhibiting calcineurin-mediated nuclear translocation of the transcription factor NFATC1. Expression of this gene in skin fibroblasts is upregulated by thyroid hormone, and the encoded protein may also play a role in endothelial cell function and angiogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
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UniProt Comments for DSCR1L1

RCAN2: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. Belongs to the RCAN family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 6p12.3

Molecular Function: nucleotide binding

Biological Process: calcineurin-NFAT signaling pathway; short-term memory; response to oxidative stress; locomotion during locomotory behavior
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DSCR1L1 antibody

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