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Uridine Monophosphate Kinase 1 (MTH879) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS629454

UCK1 (Uridine-cytidine kinase 1) phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. This enzyme does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Of note, UCK1 is able to use either ATP or GTP as a… More details

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Product Overview

Online Datasheet in PDF
Product Name
Uridine Monophosphate Kinase 1 (MTH879), Polyclonal Antibody
Full Product Name
Uridine Monophosphate Kinase 1, NT (Cytidine monophosphokinase 1, UCK 1, Uridine-cytidine kinase 1, Uridine monophosphokinase 1, URK1)
Product Gene Name
Product Synonym Names
Anti -Uridine Monophosphate Kinase 1, NT (Cytidine monophosphokinase 1, UCK 1, Uridine-cytidine kinase 1, Uridine monophosphokinase 1, URK1)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human UCK. Species Crossreactivity: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
24,439 Da
Chromosome Location
NC_000916.1 (800264..800938). Location: clone: MTH
3D Structure
ModBase 3D Structure for O26965
Immunogen
Synthetic peptide selected from the N-terminal region of human UCK (KLH).
Applications Tested/Suitable for anti-MTH879 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-MTH879 antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100

Western Blot (WB) of anti-MTH879 antibody

The anti-UCK Pab is used in Western blot to detect UCK in mouse cerebellum tissue lysate (Lane 1) and HepG2 cell lysate (Lane 2).
Rabbit Anti-MTH879 Polyclonal Antibody – Cat# MBS629454

Immunohistochemistry (IHC) of anti-MTH879 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Rabbit Anti-MTH879 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS629454

Other Notes

Small volumes of anti-MTH879 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MTH879 purchase

MBS629454 is an antibody targeting MTH879. Also known as Uridine Monophosphate Kinase 1, NT (Cytidine monophosphokinase 1, UCK 1, Uridine-cytidine kinase 1, Uridine monophosphokinase 1, URK1). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MTH879. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
uridine monophosphate kinase
NCBI Official Symbol
MTH879
UniProt Protein Name
Uridylate kinase
UniProt Synonym Protein Names
Uridine monophosphate kinase
UniProt Gene Name
pyrH
UniProt Synonym Gene Names
UK; UMP kinase; UMPK
UniProt Entry Name
PYRH_METTH
NCBI Protein Information
uridine monophosphate kinase

UniProt Comments for MTH879

Function: Catalyzes the reversible phosphorylation of UMP to UDP

By similarity. HAMAP-Rule MF_01220

Catalytic activity: ATP + UMP = ADP + UDP. HAMAP-Rule MF_01220

Enzyme regulation: Inhibited by UTP

By similarity. HAMAP-Rule MF_01220

Pathway: Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1. HAMAP-Rule MF_01220

Subunit structure: Homohexamer

By similarity. HAMAP-Rule MF_01220

Subcellular location: Cytoplasm

By similarity HAMAP-Rule MF_01220.

Sequence similarities: Belongs to the UMP kinase family.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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