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ARPC1A Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS629556

ARPC1A is one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein ARPC1B. The similarity between these two proteins suggests that they both may function as p41… More details

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Product Overview

Online Datasheet in PDF
Product Name
ARPC1A, Polyclonal Antibody
Full Product Name
ARPC1A, ID (Actin-related Protein 2/3 Complex Subunit 1A, SOP2-like Protein, SOP2L)
Product Gene Name
anti-ARPC1A antibody
Product Synonym Names
Anti -ARPC1A, ID (Actin-related Protein 2/3 Complex Subunit 1A, SOP2-like Protein, SOP2L)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human ARPC1A.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
40,954 Da
Chromosome Location
Chromosome: 7; NC_000007.13 (98923496..98963885). Location: 7q22.1
3D Structure
ModBase 3D Structure for Q53GB6
Immunogen
Synthetic peptide selected from the Center region of human ARPC1A (KLH).

Product Categories/Family for anti-ARPC1A antibody

Antibodies; Abs to Actin Related Proteins
Applications Tested/Suitable for anti-ARPC1A antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-ARPC1A antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100

Western Blot (WB) of anti-ARPC1A antibody

Western blot analysis of ARPC1A antibody (Center) in Y79 cell line lysates (35ug/lane). ARPC1A (arrow) was detected using the purified Pab.
Rabbit Anti-ARPC1A Polyclonal Antibody – Cat# MBS629556

Flow Cytometry (FC/FACS) of anti-ARPC1A antibody

Flow cytometric analysis of hela cells using ARPC1A Antibody (Center)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-ARPC1A Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS629556

Immunohistochemistry (IHC) of anti-ARPC1A antibody

ARPC1A Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ARPC1A Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-ARPC1A Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS629556

Other Notes

Small volumes of anti-ARPC1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ARPC1A purchase

MBS629556 is an antibody targeting ARPC1A. Also known as ARPC1A, ID (Actin-related Protein 2/3 Complex Subunit 1A, SOP2-like Protein, SOP2L). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ARPC1A. It may not necessarily be applicable to this product.

NCBI GI #
300360515
NCBI GeneID
10552
NCBI Accession #
NP_001177925.1
UniProt Primary Accession #
Q53GB6
UniProt Related Accession #
Q53GB6; Q59GQ0; Q75MY0; Q92747
GenBank Nucleotide #
NM_001190996.1
NCBI Official Full Name
actin-related protein 2/3 complex subunit 1A isoform 2
NCBI Official Synonym Full Names
actin related protein 2/3 complex, subunit 1A, 41kDa
NCBI Official Symbol
ARPC1A
NCBI Official Synonym Symbols
Arc40; SOP2L; SOP2Hs
UniProt Protein Name
Actin related protein 2/3 complex subunit 1A variant
Protein Family
Actin-related protein 2/3 complex
UniProt Entry Name
Q53GB6_HUMAN
NCBI Protein Information
actin-related protein 2/3 complex subunit 1A; SOP2-like protein; OTTHUMP00000206032; OTTHUMP00000206034; actin binding protein (Schizosaccharomyces pombe sop2-like)

NCBI Summary for ARPC1A

This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
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UniProt Comments for ARPC1A

ARPC1A: Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Belongs to the WD repeat ARPC1 family.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 7q22.1

Cellular Component: Arp2/3 protein complex; cytosol; actin cytoskeleton

Molecular Function: actin filament binding; actin binding

Biological Process: axon guidance; ephrin receptor signaling pathway; innate immune response; actin cytoskeleton organization and biogenesis
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Research Articles on ARPC1A

1. Genome-wide association study of gene-disease association. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ARPC1A antibody

 Products by Pathway  Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Pathogenic Escherichia Coli Infection Pathway antibodies  Pathogenic Escherichia Coli Infection Pathway Diagram
 Pathogenic Escherichia Coli Infection Pathway antibodies  Pathogenic Escherichia Coli Infection Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram

Diseases associated with anti-ARPC1A antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1 publications with ARPC1A and Neoplasms

Organs/Tissues associated with anti-ARPC1A antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2 publications with ARPC1A and Blood
 Vascular Antibodies  >1 publications with ARPC1A and Vascular
 Adrenal Gland Antibodies  >1 publications with ARPC1A and Adrenal Gland
 Embryonic Tissue Antibodies  >1 publications with ARPC1A and Embryonic Tissue
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