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T-Complex Protein 1 Subunit Gamma (CCT3) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS629601

CCT3 is a molecular chaperone that is member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides… More details

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Product Overview

Online Datasheet in PDF
Product Name
T-complex Protein 1 Subunit gamma (CCT3), Polyclonal Antibody
Full Product Name
T-complex Protein 1 Subunit gamma, ID (CCT3, TCP-1-gamma, CCT-gamma, hTRiC5, TRIC5, CCTG)
Product Gene Name
anti-CCT3 antibody
Product Synonym Names
Anti -T-complex Protein 1 Subunit gamma, ID (CCT3, TCP-1-gamma, CCT-gamma, hTRiC5, TRIC5, CCTG)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human CCT3.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
60,534 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (156278752..156308195, complement). Location: 1q23
OMIM
600114
3D Structure
ModBase 3D Structure for P49368
Immunogen
Synthetic peptide selected from the Center region of human CCT3 (KLH).

Product Categories/Family for anti-CCT3 antibody

Antibodies; Abs to Actin Related Proteins
Applications Tested/Suitable for anti-CCT3 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-CCT3 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100

Western Blot (WB) of anti-CCT3 antibody

Western blot analysis of CCT3 Antibody (Center) in MCF7,CEM,K562,HL-60,Hela cell line lysates (35ug/lane).CCT3 (arrow) was detected using the purified Pab.
Rabbit Anti-CCT3 Polyclonal Antibody – Cat# MBS629601

Western Blot (WB) of anti-CCT3 antibody

Western blot analysis of CCT3 (arrow) using rabbit polyclonal CCT3 Antibody (Center) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CCT3 gene (Lane 2) .
Rabbit Anti-CCT3 Polyclonal Antibody, Western Blot (WB) – Cat# MBS629601

Immunohistochemistry (IHC) of anti-CCT3 antibody

Formalin-fixed and paraffin-embedded human lung carcinoma reacted with CCT3 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-CCT3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS629601

Flow Cytometry (FC/FACS) of anti-CCT3 antibody

Flow cytometric analysis of K562 cells using CCT3 Antibody (Center)(bottom histogram) compared to a negative control cell (top histogram)FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-CCT3 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS629601

Other Notes

Small volumes of anti-CCT3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCT3 purchase

MBS629601 is an antibody targeting CCT3. Also known as T-complex Protein 1 Subunit gamma, ID (CCT3, TCP-1-gamma, CCT-gamma, hTRiC5, TRIC5, CCTG). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CCT3. It may not necessarily be applicable to this product.

NCBI GI #
58761484
NCBI GeneID
7203
NCBI Accession #
NP_001008800.1
UniProt Primary Accession #
P49368
UniProt Secondary Accession #
Q5SZY1; Q9BR64
UniProt Related Accession #
P49368; Q2TU64; Q59H77; Q5SZX8; Q5SZY0
GenBank Nucleotide #
NM_001008800.2
NCBI Official Full Name
T-complex protein 1 subunit gamma isoform c
NCBI Official Synonym Full Names
chaperonin containing TCP1, subunit 3 (gamma)
NCBI Official Symbol
CCT3
NCBI Official Synonym Symbols
CCTG; PIG48; TRIC5; CCT-gamma; TCP-1-gamma
UniProt Protein Name
T-complex protein 1 subunit gamma
UniProt Synonym Protein Names
CCT-gamma; hTRiC5
Protein Family
Thermosome
UniProt Gene Name
CCT3
UniProt Synonym Gene Names
CCTG; TRIC5
UniProt Entry Name
TCPG_HUMAN
NCBI Protein Information
T-complex protein 1 subunit gamma; hTRiC5; OTTHUMP00000025735; OTTHUMP00000231494; OTTHUMP00000231497; T-complex protein 1, gamma subunit; TCP1 (t-complex-1) ring complex, polypeptide 5

NCBI Summary for CCT3

The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants have been characterized for this gene. In addition, a pseudogene of this gene has been found on chromosome 8. [provided by RefSeq]
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UniProt Comments for CCT3

CCT-gamma: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin. Belongs to the TCP-1 chaperonin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Chaperone; Cytoskeletal

Chromosomal Location of Human Ortholog: 1q23

Cellular Component: chaperonin-containing T-complex; microtubule; cytoskeleton; cytoplasm; plasma membrane; cytosol

Molecular Function: protein binding; unfolded protein binding; ATP binding

Biological Process: 'de novo' posttranslational protein folding; cellular protein metabolic process; protein folding; binding of sperm to zona pellucida; pore complex biogenesis
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Research Articles on CCT3

1. Observational study of gene-disease association. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CCT3 antibody

 Products by Pathway  Pathway Diagram
 Association Of TriC/CCT With Target Proteins During Biosynthesis Pathway antibodies  Association Of TriC/CCT With Target Proteins During Biosynthesis Pathway Diagram
 Chaperonin-mediated Protein Folding Pathway antibodies  Chaperonin-mediated Protein Folding Pathway Diagram
 Cooperation Of Prefoldin And TriC/CCT In Actin And Tubulin Folding Pathway antibodies  Cooperation Of Prefoldin And TriC/CCT In Actin And Tubulin Folding Pathway Diagram
 Folding Of Actin By CCT/TriC Pathway antibodies  Folding Of Actin By CCT/TriC Pathway Diagram
 Formation Of Tubulin Folding Intermediates By CCT/TriC Pathway antibodies  Formation Of Tubulin Folding Intermediates By CCT/TriC Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Prefoldin Mediated Transfer Of Substrate To CCT/TriC Pathway antibodies  Prefoldin Mediated Transfer Of Substrate To CCT/TriC Pathway Diagram
 Protein Folding Pathway antibodies  Protein Folding Pathway Diagram

Diseases associated with anti-CCT3 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >7 publications with CCT3 and Neoplasms
 Carcinoma Antibodies  >5 publications with CCT3 and Carcinoma
 Adenocarcinoma Antibodies  >3 publications with CCT3 and Adenocarcinoma
 Liver Diseases Antibodies  >3 publications with CCT3 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >3 publications with CCT3 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >3 publications with CCT3 and Liver Neoplasms
 Female Urogenital Diseases Antibodies  >2 publications with CCT3 and Female Urogenital Diseases
 Congenital Abnormalities Antibodies  >1 publications with CCT3 and Congenital Abnormalities
 Lymphoma, B-Cell Antibodies  >1 publications with CCT3 and Lymphoma, B-Cell
 Lung Neoplasms Antibodies  >1 publications with CCT3 and Lung Neoplasms

Organs/Tissues associated with anti-CCT3 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >3 publications with CCT3 and Liver
 Blood Antibodies  >2 publications with CCT3 and Blood
 Kidney Antibodies  >2 publications with CCT3 and Kidney
 Brain Antibodies  >2 publications with CCT3 and Brain
 Muscle Antibodies  >1 publications with CCT3 and Muscle
 Ovary Antibodies  >1 publications with CCT3 and Ovary
 Eye Antibodies  >1 publications with CCT3 and Eye
 Lung Antibodies  >1 publications with CCT3 and Lung
 Testis Antibodies  >1 publications with CCT3 and Testis
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