Integrin, Beta3 Antibody – Rabbit Polyclonal

Integrin b3, also known as CD61, is a 130kD transmembrane glycoprotein that binds noncovalently in complexes with integrin a subunits (aIIb, av) to form the functional receptor that binds to specific extracellular matrix proteins (e.g., fibronectin, vitronectin, etc.). Integrin receptors are involved in the regulation of a variety of important biological functions, including embryonic,development, wound repair, hemostasis, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor cell growth, and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and/or on adjacent cells. The clustering of integrin receptors on the cell surface and their binding to the extracellular matrix leads to the formation of focal contacts and the activation of various signal transduction pathways. Phosphorylation of tyrosine 773 on Integrin b3 activates the receptor and promotes cell adhesion. Tyr773 is commonly referred to as Tyr747, the corresponding site in the chicken Integrin b3 protein.

Small volumes of anti-Integrin, beta3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS629642 is an antibody targeting Integrin, beta3. Also known as Integrin, beta3 (Platelet Glycoprotein IIIa, CD61, GP3A, GPIIIa, ITGB3, NAIT, Platelet Fibrinogen Receptor beta Subunit, Platelet Membrane Glycoprotein IIIa). Reactive in Human, Mouse. Host: Rabbit.