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PDXK Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS629648

Pyridoxal kinase (PDXK) converts vitamin B6 to pyridoxal-5-phosphate (PLP), an essential cofactor in the intermediate metabolism of amino acids and neurotransmitters. The PDXK gene encodes a 312aa polypeptide, and expression of the cDNA reveals pyridoxal… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
PDXK, Polyclonal Antibody
Full Product Name
PDXK, NT (Pyridoxal Kinase, Pyridoxine Kinase, C21orf97, C21orf124, DKFZp566A071, FLJ31940, FLJ37311, MGC15873, MGC31754, MGC52346, PKH, PNK, PRED79)
Product Gene Name
anti-PDXK antibody
Product Synonym Names
Anti -PDXK, NT (Pyridoxal Kinase, Pyridoxine Kinase, C21orf97, C21orf124, DKFZp566A071, FLJ31940, FLJ37311, MGC15873, MGC31754, MGC52346, PKH, PNK, PRED79)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS
Concentration
2.52mg/ml (lot specific)
Specificity
Recognizes human PDXK. Species Crossreactivity: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
35,102 Da
Chromosome Location
Chromosome: 21; NC_000021.8 (45138978..45182188). Location: 21q22.3
OMIM
179020
3D Structure
ModBase 3D Structure for O00764
Type
Pab
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within aa 1-30 from human PDXK.
Grade
Purified

Product Categories/Family for anti-PDXK antibody

Antibodies; Abs to Protein Kinases
Applications Tested/Suitable for anti-PDXK antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-PDXK antibody
ELISA: 1:1000
Optimal dilutions to be determined by researcher

Western Blot (WB) of anti-PDXK antibody

The anti-PDXK Pab is used in Western blot to detect PDXK in mouse intestine tissue lysate (Lane 1) and Hela cell lysate (Lane 2).
Rabbit Anti-PDXK Polyclonal Antibody – Cat# MBS629648

Western Blot (WB) of anti-PDXK antibody

Western blot analysis of PDXK (arrow) using rabbit polyclonal PDXK Antibody (H13) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the PDXK gene.
Rabbit Anti-PDXK Polyclonal Antibody, Western Blot (WB) – Cat# MBS629648

Other Notes

Small volumes of anti-PDXK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PDXK purchase

MBS629648 is an antibody targeting PDXK. Also known as PDXK, NT (Pyridoxal Kinase, Pyridoxine Kinase, C21orf97, C21orf124, DKFZp566A071, FLJ31940, FLJ37311, MGC15873, MGC31754, MGC52346, PKH, PNK, PRED79). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PDXK. It may not necessarily be applicable to this product.

NCBI GI #
13543317
NCBI GeneID
8566
NCBI Accession #
AAH05825.1
UniProt Primary Accession #
O00764
UniProt Secondary Accession #
Q7Z2Y0; Q9BS02
UniProt Related Accession #
O00764
NCBI Official Full Name
PDXK protein
NCBI Official Synonym Full Names
pyridoxal (pyridoxine, vitamin B6) kinase
NCBI Official Symbol
PDXK
NCBI Official Synonym Symbols
PKH; PNK; PRED79; C21orf97; C21orf124
UniProt Protein Name
Pyridoxal kinase
UniProt Synonym Protein Names
Pyridoxine kinase
Protein Family
Putative pyridoxine kinase
UniProt Gene Name
PDXK
UniProt Synonym Gene Names
C21orf124; C21orf97; PKH; PNK
UniProt Entry Name
PDXK_HUMAN
NCBI Protein Information
pyridoxal kinase; pyridoxine kinase; vitamin B6 kinase; pyridoxamine kinase

NCBI Summary for PDXK

The protein encoded by this gene phosphorylates vitamin B6, a step required for the conversion of vitamin B6 to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. The encoded protein is cytoplasmic and probably acts as a homodimer. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
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UniProt Comments for PDXK

PDXK: Required for synthesis of pyridoxal-5-phosphate from vitamin B6. Belongs to the pyridoxine kinase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.1.35; Cofactor and Vitamin Metabolism - vitamin B6; Kinase, other

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: nucleoplasm; cytoplasm; cytosol; nucleus

Molecular Function: potassium ion binding; sodium ion binding; protein homodimerization activity; zinc ion binding; pyridoxal kinase activity; magnesium ion binding; lithium ion binding; ATP binding; pyridoxal phosphate binding

Biological Process: cell proliferation; vitamin metabolic process; vitamin B6 metabolic process; pyridoxal 5'-phosphate salvage; phosphorylation; water-soluble vitamin metabolic process; pyridoxal phosphate biosynthetic process
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Research Articles on PDXK

1. The affected pyridoxine metabolism is discussed as an inborn genetic trait in epilepsy in general, rather than a specific sign of pyridoxine-dependent epilepsy solely.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PDXK antibody

 Reference Product  PubMed Publications
 PDXP antibody  >3 publications with PDXK and PDXP
 TRAPPC4 antibody  >1 publications with PDXK and TRAPPC4
 DBP antibody  >1 publications with PDXK and DBP
 TEF antibody  >1 publications with PDXK and TEF

Pathways associated with anti-PDXK antibody

 Products by Pathway  Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Vitamins And Cofactors Pathway antibodies  Metabolism Of Vitamins And Cofactors Pathway Diagram
 Metabolism Of Water-soluble Vitamins And Cofactors Pathway antibodies  Metabolism Of Water-soluble Vitamins And Cofactors Pathway Diagram
 Vitamin B6 Metabolism Pathway antibodies  Vitamin B6 Metabolism Pathway Diagram
 Vitamin B6 Metabolism Pathway antibodies  Vitamin B6 Metabolism Pathway Diagram
 Vitamins B6 Activation To Pyridoxal Phosphate Pathway antibodies  Vitamins B6 Activation To Pyridoxal Phosphate Pathway Diagram
 Pyridoxal 5'-phosphate Salvage Pathway antibodies  Pyridoxal 5'-phosphate Salvage Pathway Diagram

Diseases associated with anti-PDXK antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >5 publications with PDXK and Carcinoma
 Neoplasms Antibodies  >5 publications with PDXK and Neoplasms
 Seizures Antibodies  >1 publications with PDXK and Seizures
 Cardiovascular Diseases Antibodies  >1 publications with PDXK and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >1 publications with PDXK and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >1 publications with PDXK and Disease Models, Animal
 Inflammation Antibodies  >1 publications with PDXK and Inflammation

Organs/Tissues associated with anti-PDXK antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >4 publications with PDXK and Lung
 Brain Antibodies  >3 publications with PDXK and Brain
 Liver Antibodies  >2 publications with PDXK and Liver
 Muscle Antibodies  >1 publications with PDXK and Muscle
 Blood Antibodies  >1 publications with PDXK and Blood
 Embryonic Tissue Antibodies  >1 publications with PDXK and Embryonic Tissue
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