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ERK3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6296544

ERK3 is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation… More details

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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
ERK3, Polyclonal Antibody
Full Product Name
ERK3, Phosphorylated (S189) (Mitogen-activated protein kinase 6, Extracellular signal-regulated kinase 3, ERK-3, MAP kinase isoform p97, p97-MAPK, MAPK6, ERK3, PRKM6,) (MaxLight 650)
Product Gene Name
anti-ERK3 antibody
Product Synonym Gene Name
MAPK6
Product Synonym Names
Mitogen-activated protein kinase 6; Extracellular signal-regulated kinase 3; ERK-3; MAP kinase isoform p97; p97-MAPK; MAPK6; ERK3; PRKM6
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight650.
Purity/Purification
Purified by Peptide Immunoaffinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
82,681 Da
Chromosome Location
Chromosome: 15; NC_000015.9 (52311411..52358462). Location: 15q21
OMIM
602904
3D Structure
ModBase 3D Structure for Q16659
Immunogen
Phospho-ERK3-S189 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S189 of human ERK3.
Conjugate
MaxLight650
Antigen Modification
Phosphorylated
Note
Preservative Free

Product Categories/Family for anti-ERK3 antibody

Antibodies; Protein Kinases
Applications Tested/Suitable for anti-ERK3 antibody
Immunohistochemistry (IHC), FLISA
Application Notes for anti-ERK3 antibody
IHC: 1:50-100
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-ERK3 antibody

Rai, R., et al., Oral Oncol. 40(7):705-712 (2004). Coulombe, P., et al., Mol. Cell. Biol. 24(14):6140-6150 (2004). Coulombe, P., et al., Mol. Cell. Biol. 23(13):4542-4558 (2003). Julien, C., et al., J. Biol. Chem. 278(43):42615-42624 (2003). Robinson, M.J., et al., J. Biol. Chem. 277(7):5094-5100 (2002).

Other Notes

Small volumes of anti-ERK3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ERK3 purchase

MBS6296544 is an antibody targeting ERK3. Also known as ERK3, Phosphorylated (S189) (Mitogen-activated protein kinase 6, Extracellular signal-regulated kinase 3, ERK-3, MAP kinase isoform p97, p97-MAPK, MAPK6, ERK3, PRKM6,) (MaxLight 650). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ERK3. It may not necessarily be applicable to this product.

NCBI GI #
4506091
NCBI GeneID
5597
NCBI Accession #
NP_002739.1
UniProt Primary Accession #
Q16659
UniProt Secondary Accession #
Q68DH4; Q8IYN8
UniProt Related Accession #
Q16659
GenBank Nucleotide #
NM_002748.3
NCBI Official Full Name
mitogen-activated protein kinase 6
NCBI Official Synonym Full Names
mitogen-activated protein kinase 6
NCBI Official Symbol
MAPK6
NCBI Official Synonym Symbols
ERK3; PRKM6; p97MAPK; HsT17250
UniProt Protein Name
Mitogen-activated protein kinase 6
UniProt Synonym Protein Names
Extracellular signal-regulated kinase 3; ERK-3; MAP kinase isoform p97
UniProt Gene Name
MAPK6
UniProt Synonym Gene Names
ERK3; PRKM6; MAP kinase 6; MAPK 6; ERK-3; p97-MAPK
UniProt Entry Name
MK06_HUMAN
NCBI Protein Information
mitogen-activated protein kinase 6; ERK-3; MAPK 6; p97-MAPK; MAP kinase 6; MAP kinase isoform p97; protein kinase, mitogen-activated 5; protein kinase, mitogen-activated 6; extracellular signal-regulated kinase 3; extracellular signal-regulated kinase, p9

NCBI Summary for ERK3

The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. [provided by RefSeq, Jul 2008]
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UniProt Comments for ERK3

ERK3: a protein kinase of the MAPK family. Plays a critical role in the regulation of cell growth and differentiation. Localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters.

Protein type: Kinase, protein; Protein kinase, CMGC; EC 2.7.11.24; Protein kinase, Ser/Thr (non-receptor); CMGC group; MAPK family; MAPK/ERK subfamily; ERK subfamily

Chromosomal Location of Human Ortholog: 15q21

Cellular Component: cytoplasm; nucleus

Molecular Function: MAP kinase activity; protein serine/threonine kinase activity; protein binding; protein heterodimerization activity; protein kinase binding; ATP binding

Biological Process: MAPKKK cascade; signal transduction; cell cycle; protein amino acid phosphorylation
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Research Articles on ERK3

1. Data show that extracellular signal-regulated kinase 3 (ERK3) is conjugated to ubiquitin via its free NH(2) terminus, and that N-terminal tags stabilize expression of p21 but not that of substrates ubiquitinated on internal lysine residues.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ERK3 antibody

 Reference Product  PubMed Publications
 MAPKAPK5 antibody  >10 publications with ERK3 and MAPKAPK5

Pathways associated with anti-ERK3 antibody

 Products by Pathway  Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Integrin-mediated Cell Adhesion Pathway antibodies  Integrin-mediated Cell Adhesion Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 Signal Transduction Of S1P Receptor Pathway antibodies  Signal Transduction Of S1P Receptor Pathway Diagram

Diseases associated with anti-ERK3 antibody

 Disease Name  Pubmed Publications
 Death Antibodies  >11 publications with ERK3 and Death
 Carcinoma Antibodies  >8 publications with ERK3 and Carcinoma
 Inflammation Antibodies  >4 publications with ERK3 and Inflammation
 Necrosis Antibodies  >4 publications with ERK3 and Necrosis
 Neoplasm Metastasis Antibodies  >2 publications with ERK3 and Neoplasm Metastasis
 Cardiovascular Diseases Antibodies  >2 publications with ERK3 and Cardiovascular Diseases
 Heart Diseases Antibodies  >2 publications with ERK3 and Heart Diseases
 Carcinoma, Squamous Cell Antibodies  >2 publications with ERK3 and Carcinoma, Squamous Cell
 Cell Transformation, Neoplastic Antibodies  >2 publications with ERK3 and Cell Transformation, Neoplastic
 Immune System Diseases Antibodies  >2 publications with ERK3 and Immune System Diseases

Organs/Tissues associated with anti-ERK3 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >11 publications with ERK3 and Muscle
 Brain Antibodies  >9 publications with ERK3 and Brain
 Blood Antibodies  >7 publications with ERK3 and Blood
 Eye Antibodies  >7 publications with ERK3 and Eye
 Vascular Antibodies  >5 publications with ERK3 and Vascular
 Lung Antibodies  >5 publications with ERK3 and Lung
 Prostate Antibodies  >4 publications with ERK3 and Prostate
 Kidney Antibodies  >4 publications with ERK3 and Kidney
 Embryonic Tissue Antibodies  >4 publications with ERK3 and Embryonic Tissue
 Skin Antibodies  >3 publications with ERK3 and Skin
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