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ERO1LB Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6296648

MBS6296648 is an antibody targeting ERO1LB. Also known as ERO1LB, CT (ERO1LB, ERO1-like protein beta, Endoplasmic oxidoreductin-1-like protein B, Oxidoreductin-1-L-beta) (Biotin). Reactive in Human, Mouse. Host: Rabbit. More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ERO1LB, Polyclonal Antibody
Full Product Name
ERO1LB, CT (ERO1LB, ERO1-like protein beta, Endoplasmic oxidoreductin-1-like protein B, Oxidoreductin-1-L-beta) (Biotin)
Product Gene Name
anti-ERO1LB antibody
Product Synonym Names
ERO1LB; ERO1-like protein beta; Endoplasmic oxidoreductin-1-like protein B; Oxidoreductin-1-L-beta
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
Purity/Purification
Purified by Protein A and Peptide Affinity Chromatography.
Specificity
Recognizes human ERO1LB. Species Crossreactivity: mouse
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
16,096 Da
OMIM
615437
3D Structure
ModBase 3D Structure for Q86YB8
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 266-293 in the C-terminal region of human ERO1LB, Swiss/UniProt Accession: Q86YB8
Conjugate
Biotin
Note
Preservative Free

Product Categories/Family for anti-ERO1LB antibody

Antibodies; Proteins
Applications Tested/Suitable for anti-ERO1LB antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB), Flow Cytometry (FC/FACS), ELISA (EIA)
Application Notes for anti-ERO1LB antibody
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-ERO1LB antibody

Western Blot analysis in MDA-MB435 cell line lysates using MBS6001250 (35ug/lane). This demonstrates MBS6001250 detected the ERO1LB protein (arrow).
Rabbit Anti-ERO1LB Polyclonal Antibody – Cat# MBS6296648

Immunohistochemistry (IHC) of anti-ERO1LB antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded mouse testis tissue using MBS6001250 followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of MBS6001250 for immunohistochemistry.
Rabbit Anti-ERO1LB Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6296648

Flow Cytometry (FC/FACS) of anti-ERO1LB antibody

Flow cytometric analysis of MDA-MB435 cells using MBS6001250 (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-ERO1LB Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6296648

Product References and Citations for anti-ERO1LB antibody

1. Landa, I., et al. PLoS Genet. 5 (9), E1000637 (2009). 2. Savu, M.K., et al. Surg Obes Relat Dis 5(2):172-180(2009). 3. Tavendale, R., et al. J. Allergy Clin. Immunol. 121(4):860-863(2008).

Other Notes

Small volumes of anti-ERO1LB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ERO1LB. It may not necessarily be applicable to this product.

NCBI GI #
697457656
NCBI Accession #
KGL94058.1
UniProt Primary Accession #
Q86YB8
UniProt Secondary Accession #
Q5T1H4; Q8IZ11; Q9NR62; B4DF57
NCBI Official Full Name
ERO1-like beta, partial
UniProt Protein Name
ERO1-like protein beta
UniProt Synonym Protein Names
Endoplasmic reticulum oxidoreductin-1-like protein B; Oxidoreductin-1-L-beta
UniProt Gene Name
ERO1LB
UniProt Synonym Gene Names
ERO1-L-beta
UniProt Entry Name
ERO1B_HUMAN

UniProt Comments for ERO1LB

ERO1LB: Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the being a source of oxidative stress. Required for the folding of cell, thereby being a source of oxidative stress. Belongs to the EROs family.

Protein type: Endoplasmic reticulum; Oxidoreductase; EC 1.8.4.-

Chromosomal Location of Human Ortholog: 1q42.2-q43

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum

Molecular Function: protein binding; unfolded protein binding; protein disulfide isomerase activity; protein disulfide oxidoreductase activity; oxidoreductase activity; oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor

Biological Process: insulin processing; protein maturation via protein folding; extracellular matrix organization and biogenesis; 4-hydroxyproline metabolic process; protein folding; cell redox homeostasis; glucose homeostasis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ERO1LB antibody

 Reference Product  PubMed Publications
 ERP44 antibody  >1 publications with ERO1LB and ERP44
 PDIA4 antibody  >1 publications with ERO1LB and PDIA4
 P4HB antibody  >1 publications with ERO1LB and P4HB

Diseases associated with anti-ERO1LB antibody

 Disease Name  Pubmed Publications
 Weight Loss Antibodies  >1 publications with ERO1LB and Weight Loss
 Disease Models, Animal Antibodies  >1 publications with ERO1LB and Disease Models, Animal
 Inflammation Antibodies  >1 publications with ERO1LB and Inflammation

Organs/Tissues associated with anti-ERO1LB antibody

 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >4 publications with ERO1LB and Pancreas
 Stomach Antibodies  >1 publications with ERO1LB and Stomach
 Blood Antibodies  >1 publications with ERO1LB and Blood
 Muscle Antibodies  >1 publications with ERO1LB and Muscle
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