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ERRFI1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6296670

ERRFI1 is a cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995 [PubMed 7641805]). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ERRFI1, Polyclonal Antibody
Full Product Name
ERRFI1, ID (ERRFI1, MIG6, ERBB receptor feedback inhibitor 1, Mitogen-inducible gene 6 protein) (Biotin)
Product Gene Name
anti-ERRFI1 antibody
Product Synonym Names
ERRFI1; MIG6; ERBB receptor feedback inhibitor 1; Mitogen-inducible gene 6 protein
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
50,560 Da
OMIM
608069
3D Structure
ModBase 3D Structure for Q9UJM3
Immunogen
ERRFI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 256-286 amino acids from the Central region of human ERRFI1.
Conjugate
Biotin
Note
Preservative Free

Product Categories/Family for anti-ERRFI1 antibody

Antibodies; Receptors
Applications Tested/Suitable for anti-ERRFI1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-ERRFI1 antibody
WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-ERRFI1 antibody

ERRFI1 Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the ERRFI1 antibody detected the ERRFI1 protein (arrow).
Rabbit Anti-ERRFI1 Polyclonal Antibody – Cat# MBS6296670

Product References and Citations for anti-ERRFI1 antibody

Frosi, Y., et al. J. Cell Biol. 189(3):557-571(2010). Ying, H., et al. Proc. Natl. Acad. Sci. U.S.A. 107(15):6912-6917(2010). Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010). Reschke, M., et al. Hepatology 51(4):1383-1390(2010). Nagashima, T., et al. FEBS J. 276(18):5239-5251(2009).

Other Notes

Small volumes of anti-ERRFI1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ERRFI1 purchase

MBS6296670 is an antibody targeting ERRFI1. Also known as ERRFI1, ID (ERRFI1, MIG6, ERBB receptor feedback inhibitor 1, Mitogen-inducible gene 6 protein) (Biotin). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ERRFI1. It may not necessarily be applicable to this product.

NCBI GI #
10047086
NCBI GeneID
54206
NCBI Accession #
NP_061821.1
UniProt Primary Accession #
Q9UJM3
UniProt Secondary Accession #
Q9NTG9; Q9UD05; B2RDX9
UniProt Related Accession #
Q9UJM3
GenBank Nucleotide #
NM_018948.3
NCBI Official Full Name
ERBB receptor feedback inhibitor 1
NCBI Official Synonym Full Names
ERBB receptor feedback inhibitor 1
NCBI Official Symbol
ERRFI1
NCBI Official Synonym Symbols
MIG6; RALT; MIG-6; GENE-33
UniProt Protein Name
ERBB receptor feedback inhibitor 1
UniProt Synonym Protein Names
Mitogen-inducible gene 6 protein; MIG-6
Protein Family
ERBB receptor feedback inhibitor
UniProt Gene Name
ERRFI1
UniProt Synonym Gene Names
MIG6; MIG-6
UniProt Entry Name
ERRFI_HUMAN
NCBI Protein Information
ERBB receptor feedback inhibitor 1

UniProt Comments for ERRFI1

MIG-6: Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development. Interacts with ERBB2. Interacts with EGFR. Levels are very low in quiescent cells. Up-regulated by mitogens. Belongs to the MIG6 family.

Protein type: Tumor suppressor; Inhibitor

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: extrinsic to internal side of plasma membrane; cytoplasm; nucleus

Molecular Function: protein binding; protein kinase binding

Biological Process: negative regulation of epidermal growth factor receptor activity; skin morphogenesis; response to stress; negative regulation of protein amino acid autophosphorylation; regulation of keratinocyte differentiation; alveolus development
Show more

Research Articles on ERRFI1

1. Cdc42 inhibition is required for Mig-6 suppression of cell migration induced by EGF

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ERRFI1 antibody

 Reference Product  PubMed Publications
 EGFR antibody  >19 publications with ERRFI1 and EGFR
 ERBB2 antibody  >2 publications with ERRFI1 and ERBB2
 CDC42 antibody  >1 publications with ERRFI1 and CDC42

Pathways associated with anti-ERRFI1 antibody

 Products by Pathway  Pathway Diagram
 EGF/EGFR Signaling Pathway antibodies  EGF/EGFR Signaling Pathway Diagram
 Signaling Pathways In Glioblastoma antibodies  Signaling Pathways In Glioblastoma Diagram

Diseases associated with anti-ERRFI1 antibody

 Disease Name  Pubmed Publications
 Hyperplasia Antibodies  >4 publications with ERRFI1 and Hyperplasia
 Skin Neoplasms Antibodies  >3 publications with ERRFI1 and Skin Neoplasms
 Liver Diseases Antibodies  >3 publications with ERRFI1 and Liver Diseases
 Hypertrophy Antibodies  >2 publications with ERRFI1 and Hypertrophy
 Cardiovascular Diseases Antibodies  >2 publications with ERRFI1 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >2 publications with ERRFI1 and Disease Models, Animal
 Weight Gain Antibodies  >1 publications with ERRFI1 and Weight Gain
 Neoplasms, Experimental Antibodies  >1 publications with ERRFI1 and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >1 publications with ERRFI1 and Liver Neoplasms
 Fibrosis Antibodies  >1 publications with ERRFI1 and Fibrosis

Organs/Tissues associated with anti-ERRFI1 antibody

 Organ/Tissue Name  Pubmed Publications
 Uterus Antibodies  >5 publications with ERRFI1 and Uterus
 Skin Antibodies  >5 publications with ERRFI1 and Skin
 Blood Antibodies  >4 publications with ERRFI1 and Blood
 Liver Antibodies  >4 publications with ERRFI1 and Liver
 Lung Antibodies  >3 publications with ERRFI1 and Lung
 Brain Antibodies  >3 publications with ERRFI1 and Brain
 Bone Antibodies  >2 publications with ERRFI1 and Bone
 Pancreas Antibodies  >2 publications with ERRFI1 and Pancreas
 Nerve Antibodies  >1 publications with ERRFI1 and Nerve
 Thyroid Antibodies  >1 publications with ERRFI1 and Thyroid
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