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ERV3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6296689

The human genome includes many retroelements including the human endogenous retroviruses (HERVs). ERV3, one of the most studied HERVs, is thought to have integrated 30 to 40 million years ago and is present in higher primates with the exception of gorillas.… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ERV3, Polyclonal Antibody
Full Product Name
ERV3, CT (ERV3-1, ERV3, HERV-R_7q21.2 provirus ancestral Env polyprotein, ERV-3 envelope protein, ERV3-1 envelope protein, Envelope polyprotein, HERV-R envelope protein, Surface protein, Transmembrane protein) (PE)
Product Gene Name
anti-ERV3 antibody
Product Synonym Names
ERV3-1; ERV3; HERV-R_7q21.2 provirus ancestral Env polyprotein; ERV-3 envelope protein; ERV3-1 envelope protein; Envelope polyprotein; HERV-R envelope protein; Surface protein; Transmembrane protein
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes human ERV3.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
3D Structure
ModBase 3D Structure for Q14264
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 445-474 in the C-terminal region of human ERV3, UniProt Accession #Q14264; NP_001007254.2.
Conjugate
PE
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-ERV3 antibody

Antibodies; Infectious Disease; HERV
Applications Tested/Suitable for anti-ERV3 antibody
Immunohistochemistry (IHC), FLISA, Western Blot (WB)
Application Notes for anti-ERV3 antibody
IHC: 1:10-50
FLISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-ERV3 antibody

Western Blot analysis in 293, HepG2 cell line lysates (35ug/lane) usingMBS6007937. This demonstrates that MBS6007937 detected the ERV3 protein (arrow).
Rabbit Anti-ERV3 Polyclonal Antibody – Cat# MBS6296689

Immunohistochemistry (IHC) of anti-ERV3 antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human skin tissue using MBS6007937 followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MBS6007937 for immunohistochemistry.
Rabbit Anti-ERV3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6296689

Product References and Citations for anti-ERV3 antibody

1. Andersson, A.C., et al. J. Virol. 79(14):9270-9284(2005). 2. Herve, C.A., et al. Genomics 83(5):940-943(2004). 3. Blaise, S., et al. Proc. Natl. Acad. Sci. U.S.A. 100(22):13013-13018(2003). 4. de Parseval, N., et al. J. Virol. 77(19):10414-10422(2003). 5. Andersson, A.C., et al. Virology 297(2):220-225(2002).

Other Notes

Small volumes of anti-ERV3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ERV3 purchase

MBS6296689 is an antibody targeting ERV3. Also known as ERV3, CT (ERV3-1, ERV3, HERV-R_7q21.2 provirus ancestral Env polyprotein, ERV-3 envelope protein, ERV3-1 envelope protein, Envelope polyprotein, HERV-R envelope protein, Surface protein, Transmembrane protein) (PE). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ERV3. It may not necessarily be applicable to this product.

NCBI GI #
145651814
NCBI GeneID
2086
NCBI Accession #
NP_001007254.2
UniProt Primary Accession #
Q14264
UniProt Related Accession #
Q14264
GenBank Nucleotide #
NM_001007253.3
NCBI Official Full Name
endogenous retrovirus group 3 member 1 Env polyprotein
NCBI Official Synonym Full Names
endogenous retrovirus group 3 member 1
NCBI Official Symbol
ERV3-1
NCBI Official Synonym Symbols
ERV3; ERVR; envR; ERV-R; HERVR; HERV-R
UniProt Protein Name
Endogenous retrovirus group 3 member 1 Env polyprotein
UniProt Synonym Protein Names
ERV-3 envelope protein; ERV3 envelope protein
Protein Family
Endogenous retrovirus group 3 member 1 Env polyprotein
UniProt Gene Name
ERV3-1
UniProt Synonym Gene Names
ERV3; ERV3 envelope protein; ERV-R envelope protein; SU; TM
UniProt Entry Name
ENR1_HUMAN
NCBI Protein Information
endogenous retrovirus group 3 member 1 Env polyprotein

NCBI Summary for ERV3

The human genome includes many retroelements including the human endogenous retroviruses (HERVs). ERV3, one of the most studied HERVs, is thought to have integrated 30 to 40 million years ago and is present in higher primates with the exception of gorillas. Taken together, the observation of genome conservation, the detection of transcript expression, and the presence of conserved ORFs is circumstantial evidence for a functional role. A functional role is also suggested by the observation that downregulation of ERV3 is reported in choriocarcinoma. [provided by RefSeq, Jul 2008]
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UniProt Comments for ERV3

ERV3: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its fusogenic properties. It can inhibit cell growth through decrease expression of cyclin B1 and increased expression of p21 in vitro. Belongs to the gamma type-C retroviral envelope protein family. HERV class-I R env subfamily.

Chromosomal Location of Human Ortholog: 7q11.2

Cellular Component: viral envelope
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Research Articles on ERV3

1. Letter: report elevated ERV3-1 levels in colorectal neoplasms.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-ERV3 antibody

 Organ/Tissue Name  Pubmed Publications
 Placenta Antibodies  >10 publications with ERV3 and Placenta
 Embryonic Tissue Antibodies  >5 publications with ERV3 and Embryonic Tissue
 Adrenal Gland Antibodies  >4 publications with ERV3 and Adrenal Gland
 Testis Antibodies  >4 publications with ERV3 and Testis
 Ovary Antibodies  >2 publications with ERV3 and Ovary
 Kidney Antibodies  >2 publications with ERV3 and Kidney
 Skin Antibodies  >2 publications with ERV3 and Skin
 Thymus Antibodies  >1 publications with ERV3 and Thymus
 Prostate Antibodies  >1 publications with ERV3 and Prostate
 Brain Antibodies  >1 publications with ERV3 and Brain
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