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FDFT1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS629669

FDFT1 catalyzes the first step in the cholesterol biosynthetic pathway, the conversion of trans-farnesyldiphosphate to squalene. The loss of promoter activity and response to sterols for FDFT1 is localized to a 69-bp section positioned 131 bp 5-prime to the… More details

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Product Overview

Online Datasheet in PDF
Product Name
FDFT1, Polyclonal Antibody
Full Product Name
FDFT1, NT (Farnesyl-diphosphate Farnesyltransferase, Squalene Synthetase, SQS, SS, FPP:FPP farnesyltransferase)
Product Gene Name
anti-FDFT1 antibody
Product Synonym Names
Anti -FDFT1, NT (Farnesyl-diphosphate Farnesyltransferase, Squalene Synthetase, SQS, SS, FPP:FPP farnesyltransferase)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human FDFT1. Species Crossreactivity: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
48,115 Da
Chromosome Location
Chromosome: 8; NC_000008.10 (11660190..11696818). Location: 8p23.1-p22
3D Structure
ModBase 3D Structure for Q6IAX1
Immunogen
Synthetic peptide selected from the N-terminal region of human FDFT1 (KLH).

Product Categories/Family for anti-FDFT1 antibody

Antibodies; Abs to Enzymes; Synthetase
Applications Tested/Suitable for anti-FDFT1 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-FDFT1 antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100

Western Blot (WB) of anti-FDFT1 antibody

The anti-FDFT1 Pab is used in Western blot to detect FDFT1 in mouse cerebellum tissue lysate.
Rabbit Anti-FDFT1 Polyclonal Antibody – Cat# MBS629669

Western Blot (WB) of anti-FDFT1 antibody

Western blot analysis of FDFT1 (arrow) using rabbit polyclonal FDFT1 Antibody (E11) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the FDFT1 gene.
Rabbit Anti-FDFT1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS629669

Immunohistochemistry (IHC) of anti-FDFT1 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Rabbit Anti-FDFT1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS629669

Other Notes

Small volumes of anti-FDFT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FDFT1 purchase

MBS629669 is an antibody targeting FDFT1. Also known as FDFT1, NT (Farnesyl-diphosphate Farnesyltransferase, Squalene Synthetase, SQS, SS, FPP:FPP farnesyltransferase). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FDFT1. It may not necessarily be applicable to this product.

NCBI GI #
48146183
NCBI GeneID
2222
UniProt Primary Accession #
Q6IAX1
UniProt Related Accession #
P37268; Q6IAX1
NCBI Official Full Name
FDFT1
NCBI Official Synonym Full Names
farnesyl-diphosphate farnesyltransferase 1
NCBI Official Symbol
FDFT1
NCBI Official Synonym Symbols
SS; SQS; DGPT; ERG9
UniProt Protein Name
FDFT1 protein
UniProt Gene Name
FDFT1
UniProt Entry Name
Q6IAX1_HUMAN
NCBI Protein Information
squalene synthase; OTTHUMP00000116011; OTTHUMP00000229500; OTTHUMP00000229503; OTTHUMP00000229504; OTTHUMP00000229505; OTTHUMP00000229508; OTTHUMP00000229509; squalene synthetase; FPP:FPP farnesyltransferase; presqualene-di-diphosphate synthase

NCBI Summary for FDFT1

This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq]
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UniProt Comments for FDFT1

FDFT1: a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq, Jul 2008]

Protein type: Lipid Metabolism - steroid biosynthesis; Membrane protein, integral; Membrane protein, multi-pass; Endoplasmic reticulum; Transferase; Oxidoreductase; EC 2.5.1.21

Chromosomal Location of Human Ortholog: 8p23.1-p22

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane

Molecular Function: farnesyl-diphosphate farnesyltransferase activity; oxidoreductase activity

Biological Process: isoprenoid biosynthetic process; cellular lipid metabolic process; farnesyl diphosphate metabolic process; steroid biosynthetic process; cholesterol biosynthetic process
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Research Articles on FDFT1

1. NASH is intimately related to fibrosis progression, the FDFT1 SNP is a good candidate for a link with inflammation and fibrosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-FDFT1 antibody

 Products by Pathway  Pathway Diagram
 Cholesterol Biosynthesis Pathway antibodies  Cholesterol Biosynthesis Pathway Diagram
 Cholesterol Biosynthesis Pathway antibodies  Cholesterol Biosynthesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Statin Pathway antibodies  Statin Pathway Diagram
 Steroid Biosynthesis Pathway antibodies  Steroid Biosynthesis Pathway Diagram
 Steroid Biosynthesis Pathway antibodies  Steroid Biosynthesis Pathway Diagram
 Cholesterol Biosynthesis I Pathway antibodies  Cholesterol Biosynthesis I Pathway Diagram
 Cholesterol Biosynthesis II (via 24,25-dihydrolanosterol) Pathway antibodies  Cholesterol Biosynthesis II (via 24,25-dihydrolanosterol) Pathway Diagram
 Cholesterol Biosynthesis III (via Desmosterol) Pathway antibodies  Cholesterol Biosynthesis III (via Desmosterol) Pathway Diagram

Diseases associated with anti-FDFT1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4 publications with FDFT1 and Neoplasms
 Carcinoma Antibodies  >3 publications with FDFT1 and Carcinoma
 Adenocarcinoma Antibodies  >3 publications with FDFT1 and Adenocarcinoma
 Stomach Neoplasms Antibodies  >3 publications with FDFT1 and Stomach Neoplasms
 Liver Diseases Antibodies  >2 publications with FDFT1 and Liver Diseases
 Head and Neck Neoplasms Antibodies  >2 publications with FDFT1 and Head and Neck Neoplasms
 Stomach Diseases Antibodies  >2 publications with FDFT1 and Stomach Diseases
 Brain Diseases Antibodies  >2 publications with FDFT1 and Brain Diseases
 Esophageal Neoplasms Antibodies  >2 publications with FDFT1 and Esophageal Neoplasms
 Breast Neoplasms Antibodies  >1 publications with FDFT1 and Breast Neoplasms

Organs/Tissues associated with anti-FDFT1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5 publications with FDFT1 and Brain
 Liver Antibodies  >4 publications with FDFT1 and Liver
 Blood Antibodies  >4 publications with FDFT1 and Blood
 Stomach Antibodies  >3 publications with FDFT1 and Stomach
 Heart Antibodies  >2 publications with FDFT1 and Heart
 Eye Antibodies  >2 publications with FDFT1 and Eye
 Prostate Antibodies  >2 publications with FDFT1 and Prostate
 Muscle Antibodies  >1 publications with FDFT1 and Muscle
 Pancreas Antibodies  >1 publications with FDFT1 and Pancreas
 Lung Antibodies  >1 publications with FDFT1 and Lung
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