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CBX8 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS629678

Chromobox homolog 8 (CBX8 or Pc3) is a member of Drosophila Polycomb group gene family. The polycomb group (PcG) genes are essential for maintenance of appropriate expression patterns of developmental master regulators and thus are essential for proper… More details

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Product Overview

Online Datasheet in PDF
Product Name
CBX8, Polyclonal Antibody
Full Product Name
CBX8, CT (Chromobox Protein Homolog 8, Polycomb 3 Homolog, Pc3, HPC3, Rectachrome 1, PC3, RC1)
Product Gene Name
anti-CBX8 antibody
Product Synonym Names
Anti -CBX8, CT (Chromobox Protein Homolog 8, Polycomb 3 Homolog, Pc3, HPC3, Rectachrome 1, PC3, RC1)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human CBX8. Species Crossreactivity: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
43,396 Da
Chromosome Location
Chromosome: 17; NC_000017.10 (77768176..77770915, complement). Location: 17q25.3
3D Structure
ModBase 3D Structure for Q9HC52
Immunogen
Synthetic peptide selected from the C-terminal region of human CBX8 (KLH).

Product Categories/Family for anti-CBX8 antibody

Antibodies; Abs to Chromatin Proteins
Applications Tested/Suitable for anti-CBX8 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CBX8 antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100

Western Blot (WB) of anti-CBX8 antibody

The anti-CBX8 C-term Pab is used in Western blot to detect CBX8 in mouse kidney tissue lysate.
Rabbit Anti-CBX8 Polyclonal Antibody – Cat# MBS629678

Immunohistochemistry (IHC) of anti-CBX8 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Rabbit Anti-CBX8 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS629678

Western Blot (WB) of anti-CBX8 antibody

CBX8 Antibody (Y321) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the CBX8 antibody detected the CBX8 protein (arrow).
Rabbit Anti-CBX8 Polyclonal Antibody, Western Blot (WB) – Cat# MBS629678

Other Notes

Small volumes of anti-CBX8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CBX8 purchase

MBS629678 is an antibody targeting CBX8. Also known as CBX8, CT (Chromobox Protein Homolog 8, Polycomb 3 Homolog, Pc3, HPC3, Rectachrome 1, PC3, RC1). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CBX8. It may not necessarily be applicable to this product.

NCBI GI #
10190682
NCBI GeneID
57332
NCBI Accession #
NP_065700.1
UniProt Primary Accession #
Q9HC52
UniProt Secondary Accession #
Q96H39; Q9NR07
UniProt Related Accession #
Q9HC52
GenBank Nucleotide #
NM_020649.2
NCBI Official Full Name
chromobox protein homolog 8
NCBI Official Synonym Full Names
chromobox homolog 8
NCBI Official Symbol
CBX8
NCBI Official Synonym Symbols
PC3; RC1
UniProt Protein Name
Chromobox protein homolog 8
UniProt Synonym Protein Names
Polycomb 3 homolog; Pc3; hPc3; Rectachrome 1
Protein Family
Chromobox protein
UniProt Gene Name
CBX8
UniProt Synonym Gene Names
PC3; RC1
UniProt Entry Name
CBX8_HUMAN
NCBI Protein Information
chromobox protein homolog 8; polycomb 3; rectachrome 1; OTTHUMP00000197310; OTTHUMP00000197311; OTTHUMP00000197312; Pc class 3 homolog; chromobox homolog 8 (Pc class homolog, Drosophila)

UniProt Comments for CBX8

CBX8: Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: nucleoplasm; heterochromatin; nuclear chromatin; PcG protein complex; nucleus

Molecular Function: protein binding; single-stranded RNA binding; ubiquitin-protein ligase activity; methylated histone residue binding

Biological Process: transcription, DNA-dependent; histone ubiquitination; negative regulation of transcription from RNA polymerase II promoter
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Research Articles on CBX8

1. CBX8 is an essential component of one of the polycomb repressive complexes, which directly regulate the expression of numerous target genes, including the INK4A-ARF locus, involved in cell-fate decisions.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CBX8 antibody

 Reference Product  PubMed Publications
 RING1 antibody  >3 publications with CBX8 and RING1
 BMI1 antibody  >3 publications with CBX8 and BMI1
 MLLT1 antibody  >1 publications with CBX8 and MLLT1

Diseases associated with anti-CBX8 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1 publications with CBX8 and Neoplasms
 Cell Transformation, Neoplastic Antibodies  >1 publications with CBX8 and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-CBX8 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >1 publications with CBX8 and Lung
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