Rabbit Anti-ESX1 Polyclonal Antibody – Cat# MBS6296896

ESX1 Antibody – Rabbit Polyclonal

Name: ESX1 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6296896
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6296896

This gene encodes a dual-function 65 kDa protein that undergoes proteolytic cleavage to produce a 45 kDa N-terminal fragment with a paired-like homeodomain and a 20 kDa C-terminal fragment with a proline-rich domain. The C-terminal fragment localizes to the… More details

$1060 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ESX1, Polyclonal Antibody

Full Product Name

ESX1, NT (ESX1, ESX1L, ESX1R, Homeobox protein ESX1, Extraembryonic, spermatogenesis, homeobox 1, Homeobox protein ESX1-N, Homeobox protein ESX1-C) (MaxLight 650)

Product Gene Name

anti-ESX1 antibody

Product Synonym Names

ESX1; ESX1L; ESX1R; Homeobox protein ESX1; Extraembryonic; spermatogenesis; homeobox 1; Homeobox protein ESX1-N; Homeobox protein ESX1-C

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight650.

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

44,297 Da

OMIM

300154

3D Structure

ModBase 3D Structure for Q8N693

Immunogen

ESX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 27-55 amino acids from the N-terminal region of human ESX1.

Conjugate

MaxLight650

Note

Preservative Free

Product Categories/Family for anti-ESX1 antibody

Antibodies; Spermatogenesis; Testis Proteins

Applications Tested/Suitable for anti-ESX1 antibody

Western Blot (WB), FLISA

Application Notes for anti-ESX1 antibody

WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-ESX1 antibody

Bonaparte, E., et al. Hum. Reprod. 25(6):1398-1403(2010). Wang, X., et al. Hum. Mol. Genet. 16(17):2053-2060(2007). Loschiavo, M., et al. Mamm. Genome 18(1):75-85(2007). Murthi, P., et al. Mol. Hum. Reprod. 12(5):335-340(2006). Yanagihara, M., et al. Oncogene 24(38):5878-5887(2005).

Other Notes

Small volumes of anti-ESX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ESX1 purchase

MBS6296896 is an antibody targeting ESX1. Also known as ESX1, NT (ESX1, ESX1L, ESX1R, Homeobox protein ESX1, Extraembryonic, spermatogenesis, homeobox 1, Homeobox protein ESX1-N, Homeobox protein ESX1-C) (MaxLight 650). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ESX1. It may not necessarily be applicable to this product.

NCBI GI #

23592228

NCBI GeneID

80712

NCBI Accession #

NP_703149.1

UniProt Primary Accession #

Q8N693

UniProt Secondary Accession #

Q7Z6K7; B0QYU3

UniProt Related Accession #

Q8N693

GenBank Nucleotide #

NM_153448.3

NCBI Official Full Name

homeobox protein ESX1

NCBI Official Synonym Full Names

ESX homeobox 1

NCBI Official Symbol

ESX1

NCBI Official Synonym Symbols

ESX1L; ESXR1

UniProt Protein Name

Homeobox protein ESX1

UniProt Synonym Protein Names

Extraembryonic, spermatogenesis, homeobox 1Cleaved into the following 2 chains:Homeobox protein ESX1-N; Homeobox protein ESX1-C

Protein Family

Homeobox protein

UniProt Gene Name

ESX1

UniProt Synonym Gene Names

ESX1L; ESX1R

UniProt Entry Name

ESX1_HUMAN

NCBI Protein Information

homeobox protein ESX1; ESX1-related protein; extraembryonic, spermatogenesis, homeobox 1 homolog

UniProt Comments for ESX1

ESX1L: May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: Xq22.1

Cellular Component: cytoplasm; nucleus

Molecular Function: sequence-specific DNA binding

Biological Process: transcription, DNA-dependent; regulation of cell cycle; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent

Research Articles on ESX1

1. ESX1 emerges as a potentially reliable molecular marker of residual spermatogenesis in azoospermic men

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ESX1 antibody

Products by Pathway	Pathway Diagram
Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies	Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies	Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram

Diseases associated with anti-ESX1 antibody

Disease Name	Pubmed Publications
Fetal Diseases Antibodies	>5 publications with ESX1 and Fetal Diseases
Fetal Growth Retardation Antibodies	>4 publications with ESX1 and Fetal Growth Retardation
Growth Disorders Antibodies	>4 publications with ESX1 and Growth Disorders
Necrosis Antibodies	>4 publications with ESX1 and Necrosis
Infertility, Male Antibodies	>1 publications with ESX1 and Infertility, Male
Cleft Palate Antibodies	>1 publications with ESX1 and Cleft Palate
Congenital Abnormalities Antibodies	>1 publications with ESX1 and Congenital Abnormalities
Fetal Death Antibodies	>1 publications with ESX1 and Fetal Death
Embryo Loss Antibodies	>1 publications with ESX1 and Embryo Loss

Organs/Tissues associated with anti-ESX1 antibody

Organ/Tissue Name	Pubmed Publications
Testis Antibodies	>11 publications with ESX1 and Testis
Brain Antibodies	>1 publications with ESX1 and Brain