Transcription Factor 7-Like 1 (TCF7L1) Antibody – Sheep Polyclonal

This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence. [provided by RefSeq]

TCF3: Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis. Down-regulates NQO1, leading to increased mitomycin c resistance. Belongs to the TCF/LEF family.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 2p11.2

Cellular Component: nucleoplasm; transcription factor complex; nucleus

Molecular Function: DNA binding; sequence-specific DNA binding; beta-catenin binding; chromatin binding; transcription factor activity

Biological Process: skin development; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; somatic stem cell maintenance; regulation of Wnt receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; axial mesoderm morphogenesis; generation of neurons; determination of anterior/posterior axis, embryo; brain development; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter, mitotic