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CAMK2G Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS629757

MBS629757 is an antibody targeting CAMK2G. Also known as CAMK2G, CT (Calcium/Calmodulin-dependent Protein Kinase Type II Subunit gamma, CaM-kinase II Subunit gamma, CaM Kinase II Subunit gamma, CAMKG). Reactive in Human, Mouse, Rat. Host: Rabbit. More details

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Product Overview

Online Datasheet in PDF
Product Name
CAMK2G, Polyclonal Antibody
Full Product Name
CAMK2G, CT (Calcium/Calmodulin-dependent Protein Kinase Type II Subunit gamma, CaM-kinase II Subunit gamma, CaM Kinase II Subunit gamma, CAMKG)
Product Gene Name
anti-CAMK2G antibody
Product Synonym Names
Anti -CAMK2G, CT (Calcium/Calmodulin-dependent Protein Kinase Type II Subunit gamma, CaM-kinase II Subunit gamma, CaM Kinase II Subunit gamma, CAMKG)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human CAMK2 delta-like. Species Crossreactivity: mouse, rat, primate.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
62,609 Da
Chromosome Location
Chromosome: 10; NC_000010.10 (75572259..75634349, complement). Location: 10q22
OMIM
602123
3D Structure
ModBase 3D Structure for Q13555
Immunogen
Synthetic peptide selected from the C-term region of human CAMK2 delta-like (KLH).

Product Categories/Family for anti-CAMK2G antibody

Antibodies; Abs to Calmodulin
Applications Tested/Suitable for anti-CAMK2G antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CAMK2G antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100

Western Blot (WB) of anti-CAMK2G antibody

The anti-CAMK2 gamma C-term Pab is used in Western blot to detect CAMK2 gamma in mouse heart tissue lysate.
Rabbit Anti-CAMK2G Polyclonal Antibody – Cat# MBS629757

Immunohistochemistry (IHC) of anti-CAMK2G antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Rabbit Anti-CAMK2G Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS629757

Western Blot (WB) of anti-CAMK2G antibody

Western blot analysis of anti-CAMK2 delta-like Antibody (C-term) in Jurkat cell line lysates (35ug/lane). CAMK2G (arrow) was detected using the purified Pab.
Rabbit Anti-CAMK2G Polyclonal Antibody, Western Blot (WB) – Cat# MBS629757

Other Notes

Small volumes of anti-CAMK2G antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CAMK2G. It may not necessarily be applicable to this product.

NCBI GI #
26667203
NCBI GeneID
818
NCBI Accession #
NP_751911.1
UniProt Primary Accession #
Q13555
UniProt Secondary Accession #
O00561; O15378; Q13279; Q13282; Q13556; Q5SQZ3; Q5SQZ4; Q5SWX4; Q7KYX5; Q8N4I3; Q8NIA4
UniProt Related Accession #
Q13555
GenBank Nucleotide #
NM_172171.2
NCBI Official Full Name
calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 1
NCBI Official Synonym Full Names
calcium/calmodulin-dependent protein kinase II gamma
NCBI Official Symbol
CAMK2G
NCBI Official Synonym Symbols
CAMK; CAMKG; CAMK-II
UniProt Protein Name
Calcium/calmodulin-dependent protein kinase type II subunit gamma
Protein Family
Calcium/calmodulin-dependent protein kinase
UniProt Gene Name
CAMK2G
UniProt Synonym Gene Names
CAMK; CAMK-II; CAMKG; CaM kinase II subunit gamma
UniProt Entry Name
KCC2G_HUMAN
NCBI Protein Information
calcium/calmodulin-dependent protein kinase type II subunit gamma; caMK-II subunit gamma; calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma

NCBI Summary for CAMK2G

The product of this gene is one of the four subunits of an enzyme which belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Many alternatively spliced transcripts encoding different isoforms have been described but the full-length nature of all the variants has not been determined.[provided by RefSeq, Mar 2011]
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UniProt Comments for CAMK2G

CAMK2G: a protein kinase of the CAMK2 family. A prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses that may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. The holoenzyme is composed of four different chains: alpha, beta, gamma, and delta. The different chains assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. May interact with BAALC, MPDZ, SYN1 and synGAP. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, CAMK; Kinase, protein; EC 2.7.11.17; Protein kinase, Ser/Thr (non-receptor); CAMK group; CAMK2 family

Chromosomal Location of Human Ortholog: 10q22

Cellular Component: nucleoplasm; sarcoplasmic reticulum membrane; membrane; plasma membrane; cytosol

Molecular Function: calmodulin binding; protein binding; protein homodimerization activity; calcium-dependent protein serine/threonine phosphatase activity; calmodulin-dependent protein kinase activity; ATP binding

Biological Process: nervous system development; synaptic transmission; dephosphorylation; insulin secretion; regulation of skeletal muscle adaptation; calcium ion transport; protein amino acid autophosphorylation; cytokine and chemokine mediated signaling pathway; regulation of calcium ion transport; cell differentiation; protein oligomerization; G1/S transition of mitotic cell cycle
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Research Articles on CAMK2G

1. the chronic gain-of-function defect in RyR2 due to CaMKII hyperphosphorylation is a novel mechanism that contributes to pathogenesis of type 2 diabetes

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CAMK2G antibody

 Products by Pathway  Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 CREB Phosphorylation Through The Activation Of CaMKII Pathway antibodies  CREB Phosphorylation Through The Activation Of CaMKII Pathway Diagram
 CREB Phosphorylation Through The Activation Of Ras Pathway antibodies  CREB Phosphorylation Through The Activation Of Ras Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Cholinergic Synapse Pathway antibodies  Cholinergic Synapse Pathway Diagram

Diseases associated with anti-CAMK2G antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >5 publications with CAMK2G and Neoplasms
 Brain Diseases Antibodies  >2 publications with CAMK2G and Brain Diseases

Organs/Tissues associated with anti-CAMK2G antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >6 publications with CAMK2G and Muscle
 Brain Antibodies  >5 publications with CAMK2G and Brain
 Heart Antibodies  >4 publications with CAMK2G and Heart
 Blood Antibodies  >3 publications with CAMK2G and Blood
 Nerve Antibodies  >2 publications with CAMK2G and Nerve
 Embryonic Tissue Antibodies  >2 publications with CAMK2G and Embryonic Tissue
 Pancreas Antibodies  >2 publications with CAMK2G and Pancreas
 Bone Antibodies  >1 publications with CAMK2G and Bone
 Testis Antibodies  >1 publications with CAMK2G and Testis
 Eye Antibodies  >1 publications with CAMK2G and Eye
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