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EPRS Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS629772

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. EPRS is a multifunctional aminoacyl-tRNA synthetase that catalyzes the aminoacylation of glutamic acid and proline tRNA species. More details

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Product Overview

Online Datasheet in PDF
Product Name
EPRS, Polyclonal Antibody
Full Product Name
EPRS, NT (Bifunctional aminoacyl-tRNA Synthetase, Cell Proliferation-inducing Gene 32 Protein, Glutamyl-tRNA Synthetase, Glutamate-tRNA Ligase, GluRS, Prolyl-tRNA Synthetase, Proline-tRNA Ligase, GLNS, PARS, QARS, QPRS, PIG32)
Product Gene Name
anti-EPRS antibody
Product Synonym Names
Anti -EPRS, NT (Bifunctional aminoacyl-tRNA Synthetase, Cell Proliferation-inducing Gene 32 Protein, Glutamyl-tRNA Synthetase, Glutamate-tRNA Ligase, GluRS, Prolyl-tRNA Synthetase, Proline-tRNA Ligase, GLNS, PARS, QARS, QPRS, PIG32)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human EPRS.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
170,591 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (220141942..220220000, complement). Location: 1q41
OMIM
138295
3D Structure
ModBase 3D Structure for P07814
Immunogen
Synthetic peptide selected from the N-terminal region of human EPRS (KLH).

Product Categories/Family for anti-EPRS antibody

Antibodies; Abs to Enzymes; Synthetase
Applications Tested/Suitable for anti-EPRS antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-EPRS antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100
Immunohistochemistry: 1:10-1:50

Western Blot (WB) of anti-EPRS antibody

Western blot analysis of anti-EPRS Pab in Jurkat cell line lysates (35ug/lane). EPRS (arrow) was detected using the purified Pab.
Rabbit Anti-EPRS Polyclonal Antibody – Cat# MBS629772

Immunohistochemistry (IHC) of anti-EPRS antibody

Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with EPRS antibody (N-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-EPRS Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS629772

Other Notes

Small volumes of anti-EPRS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EPRS purchase

MBS629772 is an antibody targeting EPRS. Also known as EPRS, NT (Bifunctional aminoacyl-tRNA Synthetase, Cell Proliferation-inducing Gene 32 Protein, Glutamyl-tRNA Synthetase, Glutamate-tRNA Ligase, GluRS, Prolyl-tRNA Synthetase, Proline-tRNA Ligase, GLNS, PARS, QARS, QPRS, PIG32). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for EPRS. It may not necessarily be applicable to this product.

NCBI GI #
116496781
NCBI GeneID
2058
UniProt Primary Accession #
P07814
UniProt Secondary Accession #
Q05BP6; Q05DF8; Q5DSM1; Q5H9S5; Q6PD57; Q86X73; A0AVA9; B9EGH3
UniProt Related Accession #
P07814; Q3KQZ8
NCBI Official Full Name
EPRS protein
NCBI Official Synonym Full Names
glutamyl-prolyl-tRNA synthetase
NCBI Official Symbol
EPRS
NCBI Official Synonym Symbols
EARS; PARS; QARS; QPRS; PIG32; GLUPRORS; DKFZp313B047
UniProt Protein Name
Bifunctional glutamate/proline--tRNA ligase
UniProt Synonym Protein Names
Bifunctional aminoacyl-tRNA synthetase; Cell proliferation-inducing gene 32 protein; Glutamatyl-prolyl-tRNA synthetaseIncluding the following 2 domains:Glutamate--tRNA ligase (EC:6.1.1.17)Alternative name(s):Glutamyl-tRNA synthetase; GluRS
UniProt Gene Name
EPRS
UniProt Synonym Gene Names
GLNS; PARS; QARS; QPRS; GluRS
UniProt Entry Name
SYEP_HUMAN
NCBI Protein Information
bifunctional aminoacyl-tRNA synthetase; OTTHUMP00000035562; proline tRNA ligase; proline-tRNA ligase; glutamate tRNA ligase; prolyl-tRNA synthetase; glutaminyl-tRNA synthetase; proliferation-inducing protein 32; proliferation-inducing gene 32 protein; cell proliferation-inducing gene 32 protein

NCBI Summary for EPRS

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a multifunctional aminoacyl-tRNA synthetase that catalyzes the aminoacylation of glutamic acid and proline tRNA species. Alternative splicing has been observed for this gene, but the full-length nature and biological validity of the variant have not been determined. [provided by RefSeq]
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UniProt Comments for EPRS

EPRS: Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. Component of the multisynthetase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthetase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl, and aspartyl-tRNA synthetases as well as three auxiliary proteins, p18, p48 and p43. Interacts with DUS2L.

Protein type: Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Ligase; EC 6.1.1.17; Translation; EC 6.1.1.15

Chromosomal Location of Human Ortholog: 1q41

Cellular Component: aminoacyl-tRNA synthetase multienzyme complex; membrane; cytoplasm; ribonucleoprotein complex; cytosol

Molecular Function: protein binding; proline-tRNA ligase activity; glutamate-tRNA ligase activity; ATP binding

Biological Process: tRNA aminoacylation for protein translation; negative regulation of translation; prolyl-tRNA aminoacylation; glutamyl-tRNA aminoacylation; protein complex assembly; gene expression
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Research Articles on EPRS

1. Study reveals a unique role of Cdk5/p35 in activation of the major noncanonical function of EPRS, namely translational control of macrophage inflammatory gene expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-EPRS antibody

 Products by Pathway  Pathway Diagram
 Aminoacyl-tRNA Biosynthesis Pathway antibodies  Aminoacyl-tRNA Biosynthesis Pathway Diagram
 Aminoacyl-tRNA Biosynthesis Pathway antibodies  Aminoacyl-tRNA Biosynthesis Pathway Diagram
 Cytosolic TRNA Aminoacylation Pathway antibodies  Cytosolic TRNA Aminoacylation Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Porphyrin And Chlorophyll Metabolism Pathway antibodies  Porphyrin And Chlorophyll Metabolism Pathway Diagram
 Porphyrin And Chlorophyll Metabolism Pathway antibodies  Porphyrin And Chlorophyll Metabolism Pathway Diagram
 TRNA Aminoacylation Pathway antibodies  TRNA Aminoacylation Pathway Diagram

Diseases associated with anti-EPRS antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >6 publications with EPRS and Neoplasms
 Substance-Related Disorders Antibodies  >5 publications with EPRS and Substance-Related Disorders
 Schizophrenia Antibodies  >5 publications with EPRS and Schizophrenia
 Neurotoxicity Syndromes Antibodies  >3 publications with EPRS and Neurotoxicity Syndromes
 Carcinoma Antibodies  >3 publications with EPRS and Carcinoma
 Adenocarcinoma Antibodies  >3 publications with EPRS and Adenocarcinoma
 Prostatic Diseases Antibodies  >2 publications with EPRS and Prostatic Diseases
 Lung Neoplasms Antibodies  >2 publications with EPRS and Lung Neoplasms
 Genital Diseases, Male Antibodies  >2 publications with EPRS and Genital Diseases, Male
 Epilepsy Antibodies  >1 publications with EPRS and Epilepsy

Organs/Tissues associated with anti-EPRS antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >11 publications with EPRS and Blood
 Brain Antibodies  >10 publications with EPRS and Brain
 Lung Antibodies  >4 publications with EPRS and Lung
 Heart Antibodies  >3 publications with EPRS and Heart
 Vascular Antibodies  >3 publications with EPRS and Vascular
 Bone Antibodies  >2 publications with EPRS and Bone
 Eye Antibodies  >2 publications with EPRS and Eye
 Mouth Antibodies  >2 publications with EPRS and Mouth
 Prostate Antibodies  >1 publications with EPRS and Prostate
 Ear Antibodies  >1 publications with EPRS and Ear
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