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FCGR1A Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6298605

FCGR1A encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. More details

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Product Overview

Online Datasheet in PDF
Product Name
FCGR1A, Polyclonal Antibody
Full Product Name
FCGR1A, ID (FCGR1A, FCG1, FCGR1, IGFR1, High affinity immunoglobulin gamma Fc receptor I, Fc-gamma RI, Fc-gamma RIA, CD64) (APC)
Product Gene Name
anti-FCGR1A antibody
Product Synonym Names
FCGR1A; FCG1; FCGR1; IGFR1; High affinity immunoglobulin gamma Fc receptor I; Fc-gamma RI; Fc-gamma RIA; CD64
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
374
OMIM
146760
3D Structure
ModBase 3D Structure for P12314
Immunogen
FCGR1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between amino acid 225-255 from the Central region of human FCGR1A.
Conjugate
APC
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-FCGR1A antibody

Antibodies; CD Markers
Applications Tested/Suitable for anti-FCGR1A antibody
Flow Cytometry (FC/FACS), FLISA, Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-FCGR1A antibody
FC/FACS: 1:10-50
FLISA: 1:1,000
IHC: 1:50-100
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-FCGR1A antibody

Western blot analysis of FCGR1A Antibody (Center) in NCI-H460 cell line lysates (35ug/lane). FCGR1A (arrow) was detected using the purified Pab.
Rabbit Anti-FCGR1A Polyclonal Antibody – Cat# MBS6298605

Immunohistochemistry (IHC) of anti-FCGR1A antibody

FCGR1A Antibody (Center) IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the FCGR1A Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-FCGR1A Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6298605

Flow Cytometry (FC/FACS) of anti-FCGR1A antibody

FCGR1A Antibody (Center) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-FCGR1A Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6298605

Product References and Citations for anti-FCGR1A antibody

Poon, I.K., et al. Blood 115(12):2473-2482(2010). Jung, S.T., et al. Proc. Natl. Acad. Sci. U.S.A. 107(2):604-609(2010). Hulse, K.E., et al. J. Allergy Clin. Immunol. 125(1):247-256(2010).

Other Notes

Small volumes of anti-FCGR1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FCGR1A purchase

MBS6298605 is an antibody targeting FCGR1A. Also known as FCGR1A, ID (FCGR1A, FCG1, FCGR1, IGFR1, High affinity immunoglobulin gamma Fc receptor I, Fc-gamma RI, Fc-gamma RIA, CD64) (APC). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FCGR1A. It may not necessarily be applicable to this product.

NCBI GI #
50403717
NCBI GeneID
2209
NCBI Accession #
P12314.2
UniProt Primary Accession #
P12314
UniProt Secondary Accession #
P12315; Q5QNW7; Q92495; Q92663
UniProt Related Accession #
P12314
NCBI Official Full Name
High affinity immunoglobulin gamma Fc receptor I
NCBI Official Synonym Full Names
Fc fragment of IgG, high affinity Ia, receptor (CD64)
NCBI Official Symbol
FCGR1A
NCBI Official Synonym Symbols
CD64; FCRI; CD64A; IGFR1
UniProt Protein Name
High affinity immunoglobulin gamma Fc receptor I
UniProt Synonym Protein Names
Fc-gamma RI; FcRI; Fc-gamma RIA; FcgammaRIa; CD_antigen: CD64
UniProt Gene Name
FCGR1A
UniProt Synonym Gene Names
FCG1; FCGR1; IGFR1; IgG Fc receptor I; FcRI; FcgammaRIa
UniProt Entry Name
FCGR1_HUMAN
NCBI Protein Information
high affinity immunoglobulin gamma Fc receptor I; fcgammaRIa; Fc-gamma RI; fc-gamma RIA; Fc gamma receptor; IgG Fc receptor I; Fc-gamma receptor I A1; Fc fragment of IgG, high affinity Ia, receptor for (CD64)

NCBI Summary for FCGR1A

This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008]

UniProt Comments for FCGR1A

FCGR1A: High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. Belongs to the immunoglobulin superfamily. FCGR1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q21.2-q21.3

Cellular Component: early endosome membrane; plasma membrane; integral to membrane

Molecular Function: protein binding; IgG binding; receptor signaling protein activity

Biological Process: antigen processing and presentation of peptide antigen via MHC class I; cytokine and chemokine mediated signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; innate immune response; antigen processing and presentation of exogenous peptide antigen via MHC class I; immune response; signal transduction; phagocytosis, engulfment
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Research Articles on FCGR1A

1. An elevated neutrophil CD64 index is associated with both mucosal inflammation and an increased risk for clinical relapse in pediatric Crohn disease.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-FCGR1A antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing-Cross Presentation Pathway antibodies  Antigen Processing-Cross Presentation Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Cross-presentation Of Soluble Exogenous Antigens (endosomes) Pathway antibodies  Cross-presentation Of Soluble Exogenous Antigens (endosomes) Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 FCGR Activation Pathway antibodies  FCGR Activation Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway antibodies  Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram

Diseases associated with anti-FCGR1A antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >31 publications with FCGR1A and Inflammation
 Necrosis Antibodies  >15 publications with FCGR1A and Necrosis
 Cardiovascular Diseases Antibodies  >8 publications with FCGR1A and Cardiovascular Diseases
 Respiratory Tract Diseases Antibodies  >8 publications with FCGR1A and Respiratory Tract Diseases
 Lung Diseases Antibodies  >6 publications with FCGR1A and Lung Diseases
 Hematologic Diseases Antibodies  >5 publications with FCGR1A and Hematologic Diseases
 Atherosclerosis Antibodies  >3 publications with FCGR1A and Atherosclerosis
 Disease Susceptibility Antibodies  >3 publications with FCGR1A and Disease Susceptibility
 Asthma Antibodies  >3 publications with FCGR1A and Asthma
 Carcinoma Antibodies  >2 publications with FCGR1A and Carcinoma

Organs/Tissues associated with anti-FCGR1A antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >78 publications with FCGR1A and Blood
 Lung Antibodies  >5 publications with FCGR1A and Lung
 Vascular Antibodies  >4 publications with FCGR1A and Vascular
 Kidney Antibodies  >3 publications with FCGR1A and Kidney
 Intestine Antibodies  >2 publications with FCGR1A and Intestine
 Stomach Antibodies  >1 publications with FCGR1A and Stomach
 Brain Antibodies  >1 publications with FCGR1A and Brain
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