FGF8 Antibody – Rabbit Polyclonal

FGF8: Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Defects in FGF8 are the cause of Kallmann syndrome type 6 (KAL6). Kallmann syndrome is a disorder that associates hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone- synthesizing neurons. In some patients other developmental anomalies can be present, which include renal agenesis, cleft lip and/or palate, selective tooth agenesis, and bimanual synkinesis. In some cases anosmia may be absent or inconspicuous. Defects in FGF8 are a cause of idiopathic hypogonadotropic hypogonadism (IHH). IHH is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. Belongs to the heparin-binding growth factors family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Secreted; Secreted, signal peptide

Cellular Component: external side of plasma membrane

Molecular Function: chemoattractant activity

Biological Process: adrenocorticotropin hormone secreting cell differentiation; apoptosis; blood vessel remodeling; BMP signaling pathway; cell fate commitment; cell proliferation in forebrain; central nervous system neuron development; determination of left/right symmetry; dorsal/ventral axon guidance; embryonic development ending in birth or egg hatching; embryonic heart tube development; embryonic hindlimb morphogenesis; fibroblast growth factor receptor signaling pathway; forebrain dorsal/ventral pattern formation; forebrain morphogenesis; forebrain neuron development; generation of neurons; gonad development; heart development; heart looping; heart morphogenesis; induction of an organ; inner ear morphogenesis; kidney development; limb morphogenesis; lung development; male genitalia development; MAPKKK cascade; mesodermal cell migration; midbrain-hindbrain boundary development; motor axon guidance; negative regulation of apoptosis; negative regulation of cardiac muscle development; negative regulation of neuron apoptosis; neural plate morphogenesis; otic vesicle formation; pallium development; patterning of blood vessels; pharyngeal system development; positive regulation of cell proliferation; positive regulation of mitosis; positive regulation of organ growth; regulation of odontogenesis of dentine-containing teeth; response to oxidative stress; subpallium development; telencephalon development; thyroid gland development; thyroid stimulating hormone secreting cell differentiation; ureteric bud branching; Wnt receptor signaling pathway through beta-catenin