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CACNG5 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS629999

L-type calcium channels are composed of five subunits. The protein CACNG5 represents one of these subunits, gamma, and is one of several gamma subunit proteins. It is an integral membrane protein that is thought to stabilize the calcium channel in an inactive… More details

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Product Overview

Online Datasheet in PDF
Product Name
CACNG5, Polyclonal Antibody
Full Product Name
CACNG5, CT (Voltage-dependent Calcium Channel gamma-5 Subunit, Neuronal Voltage-gated Calcium Channel gamma-5 Subunit)
Product Gene Name
Product Synonym Names
Anti -CACNG5, CT (Voltage-dependent Calcium Channel gamma-5 Subunit, Neuronal Voltage-gated Calcium Channel gamma-5 Subunit)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human CACNG5.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
30,903 Da
Chromosome Location
Chromosome: 17; NC_000017.10 (64873451..64881357). Location: 17q24
OMIM
606405
3D Structure
ModBase 3D Structure for Q9UF02
Immunogen
Synthetic peptide selected from the C-terminal region of human CACNG5 (KLH).

Product Categories/Family for anti-CACNG5 antibody

Applications Tested/Suitable for anti-CACNG5 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-CACNG5 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100

Western Blot (WB) of anti-CACNG5 antibody

Western blot analysis of CACNG5 antibody (C-term) in K562 cell line lysates (35ug/lane). CACNG5 (arrow) was detected using the purified Pab.
Rabbit Anti-CACNG5 Polyclonal Antibody – Cat# MBS629999

Immunohistochemistry (IHC) of anti-CACNG5 antibody

Formalin-fixed and paraffin-embedded human brain tissue reacted with CACNG5 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-CACNG5 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS629999

Flow Cytometry (FC/FACS) of anti-CACNG5 antibody

Flow cytometric analysis of K562 cells using CACNG5 Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-CACNG5 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS629999

Other Notes

Small volumes of anti-CACNG5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CACNG5 purchase

MBS629999 is an antibody targeting CACNG5. Also known as CACNG5, CT (Voltage-dependent Calcium Channel gamma-5 Subunit, Neuronal Voltage-gated Calcium Channel gamma-5 Subunit). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CACNG5. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
calcium channel gamma 5 subunit
NCBI Official Synonym Full Names
calcium channel, voltage-dependent, gamma subunit 5
NCBI Official Symbol
CACNG5
NCBI Official Synonym Symbols
MGC126656; MGC126682
UniProt Protein Name
Voltage-dependent calcium channel gamma-5 subunit
UniProt Synonym Protein Names
Neuronal voltage-gated calcium channel gamma-5 subunit; Transmembrane AMPAR regulatory protein gamma-5
UniProt Gene Name
CACNG5
UniProt Entry Name
CCG5_HUMAN
NCBI Protein Information
voltage-dependent calcium channel gamma-5 subunit; TARP gamma-5; OTTHUMP00000232948; transmembrane AMPAR regulatory protein gamma-5; neuronal voltage-gated calcium channel gamma-5 subunit

NCBI Summary for CACNG5

The protein encoded by this gene is a type II transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type I TARP and a calcium channel gamma subunit. This gene is a susceptibility locus for schizophrenia and bipolar disorder. [provided by RefSeq]
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UniProt Comments for CACNG5

CACNG5: Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, calcium

Chromosomal Location of Human Ortholog: 17q24

Cellular Component: postsynaptic membrane; postsynaptic density; cell junction

Molecular Function: voltage-gated calcium channel activity; ion transmembrane transporter activity

Biological Process: transport
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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