• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

CLIP1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS630046

CLIP1 may be a intermediate filament associated protein that links endocytic vesicles to microtubules. More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CLIP1, Polyclonal Antibody
Full Product Name
CLIP1, NT (Cytoplasmic Linker Protein 1, Reed-Sternberg Intermediate Filament-Associated Protein, Cytoplasmic Linker Protein 170 alpha-2, CLIP-170, Restin, CAP-Gly Domain-containing Linker Protein 1, CYLN1, RSN)
Product Gene Name
anti-CLIP1 antibody
Product Synonym Names
Anti -CLIP1, NT (Cytoplasmic Linker Protein 1, Reed-Sternberg Intermediate Filament-Associated Protein, Cytoplasmic Linker Protein 170 alpha-2, CLIP-170, Restin, CAP-Gly Domain-containing Linker Protein 1, CYLN1, RSN)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human CLIP1. Species Crossreactivity: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
162,246 Da
Chromosome Location
Chromosome: 12; NC_000012.11 (122755981..122907116, complement). Location: 12q24.3
OMIM
179838
3D Structure
ModBase 3D Structure for P30622
Immunogen
Synthetic peptide selected from the N-terminal region of human CLIP1 (KLH).

Product Categories/Family for anti-CLIP1 antibody

Antibodies; Abs to Proteins
Applications Tested/Suitable for anti-CLIP1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-CLIP1 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500

Western Blot (WB) of anti-CLIP1 antibody

Western blot analysis of CLIP1 Antibody (N-term) in Hela cell line lysates (35ug/lane). CLIP1 (arrow) was detected using the purified Pab.
Rabbit Anti-CLIP1 Polyclonal Antibody – Cat# MBS630046

Western Blot (WB) of anti-CLIP1 antibody

Western blot analysis of CLIP1 Antibody (N-term) in mouse cerebellum tissue lysates (35ug/lane). CLIP1 (arrow) was detected using the purified Pab.
Rabbit Anti-CLIP1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS630046

Immunohistochemistry (IHC) of anti-CLIP1 antibody

CLIP1 Antibody (N-term) IHC analysis in formalin fixed and paraffin embedded mouse brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CLIP1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-CLIP1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS630046

Flow Cytometry (FC/FACS) of anti-CLIP1 antibody

CLIP1 Antibody (N-term) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-CLIP1 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS630046

Other Notes

Small volumes of anti-CLIP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CLIP1 purchase

MBS630046 is an antibody targeting CLIP1. Also known as CLIP1, NT (Cytoplasmic Linker Protein 1, Reed-Sternberg Intermediate Filament-Associated Protein, Cytoplasmic Linker Protein 170 alpha-2, CLIP-170, Restin, CAP-Gly Domain-containing Linker Protein 1, CYLN1, RSN). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CLIP1. It may not necessarily be applicable to this product.

NCBI GI #
116497023
NCBI GeneID
6249
UniProt Primary Accession #
P30622
UniProt Secondary Accession #
Q17RS4; Q29RG0; A0AVD3
UniProt Related Accession #
O43667; P30622; Q59GJ4; Q6P5Z9; Q6Q318; Q86WU4
NCBI Official Full Name
CLIP1 protein
NCBI Official Synonym Full Names
CAP-GLY domain containing linker protein 1
NCBI Official Symbol
CLIP1
NCBI Official Synonym Symbols
RSN; CLIP; CYLN1; CLIP170; CLIP-170; MGC131604
UniProt Protein Name
CAP-Gly domain-containing linker protein 1
UniProt Synonym Protein Names
Cytoplasmic linker protein 1; Cytoplasmic linker protein 170 alpha-2; CLIP-170; Reed-Sternberg intermediate filament-associated protein; Restin
Protein Family
CAP-Gly domain-containing linker protein
UniProt Gene Name
CLIP1
UniProt Synonym Gene Names
CYLN1; RSN
UniProt Entry Name
CLIP1_HUMAN
NCBI Protein Information
CAP-Gly domain-containing linker protein 1; OTTHUMP00000239757; OTTHUMP00000239758; OTTHUMP00000239759; OTTHUMP00000239761; cytoplasmic linker 1; cytoplasmic linker protein 1; cytoplasmic linker protein 170 alpha-2; reed-Sternberg intermediate filament-associated protein; Reed-Steinberg cell-expressed intermediate filament-associated protein; restin (Reed-Steinberg cell-expressed intermediate filament-associated protein)

NCBI Summary for CLIP1

The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

UniProt Comments for CLIP1

Restin: Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. Interacts with MTOR; phosphorylates and regulates CLIP1. Interacts (via CAP-Gly domains) with tubulin. Interacts with SLAIN2. Interacts (via zinc finger) with DCTN1. Interacts with MAPRE1 and MAPRE3. Detected in dendritic cells. Highly expressed in the Reed-Sternberg cells of Hodgkin disease. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 12q24.3

Cellular Component: microtubule cytoskeleton; kinetochore; ruffle; microtubule; centrosome; cytoplasmic vesicle membrane; cytoplasmic microtubule; cytoplasm; intermediate filament; cytosol; endosome

Molecular Function: tubulin binding; microtubule plus-end binding; protein binding; protein homodimerization activity; nucleic acid binding; zinc ion binding; microtubule binding; metal ion binding

Biological Process: mitosis; positive regulation of microtubule polymerization; mitotic cell cycle; microtubule bundle formation
Show more

Research Articles on CLIP1

1. Herein, the authors have identified polo-like kinase 1 (Plk1) and casein kinase 2 (CK2) as two kinases of CLIP-170 and mapped S195 and S1318 as their respective phosphorylation sites.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CLIP1 antibody

 Products by Pathway  Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 DNA Replication Pathway antibodies  DNA Replication Pathway Diagram
 Lissencephaly Gene (LIS1) In Neuronal Migration And Development Pathway antibodies  Lissencephaly Gene (LIS1) In Neuronal Migration And Development Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 Mitotic M-M/G1 Phases Pathway antibodies  Mitotic M-M/G1 Phases Pathway Diagram
 Mitotic Prometaphase Pathway antibodies  Mitotic Prometaphase Pathway Diagram
 MTOR Signaling Pathway antibodies  MTOR Signaling Pathway Diagram

Diseases associated with anti-CLIP1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >2 publications with CLIP1 and Neoplasms
 Leukemia Antibodies  >2 publications with CLIP1 and Leukemia
 Leukemia, Myeloid, Acute Antibodies  >1 publications with CLIP1 and Leukemia, Myeloid, Acute
 Pancreatic Neoplasms Antibodies  >1 publications with CLIP1 and Pancreatic Neoplasms
 Neuroblastoma Antibodies  >1 publications with CLIP1 and Neuroblastoma
 Lymphoma Antibodies  >1 publications with CLIP1 and Lymphoma
 Leukemia, Myeloid Antibodies  >1 publications with CLIP1 and Leukemia, Myeloid
 Cell Transformation, Neoplastic Antibodies  >1 publications with CLIP1 and Cell Transformation, Neoplastic
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000