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CANT1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS630047

CANT1 belongs to the apyrase family. It functions as a calcium-dependent nucleotidase with a preference for UDP. More details

$895 / 0.2 mL +1 FREE 8GB USB
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CANT1, Polyclonal Antibody
Full Product Name
CANT1, NT (Putative NF-kappa-B-activating Protein 107, Putative MAPK-activating Protein PM09, Apyrase Homolog, Soluble Calcium-activated Nucleotidase 1, SCAN-1, SHAPY)
Product Gene Name
anti-CANT1 antibody
Product Synonym Names
Anti -CANT1, NT (Putative NF-kappa-B-activating Protein 107, Putative MAPK-activating Protein PM09, Apyrase Homolog, Soluble Calcium-activated Nucleotidase 1, SCAN-1, SHAPY)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human CANT1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
44,840 Da
Chromosome Location
Chromosome: 17; NC_000017.10 (76987798..77005899, complement). Location: 17q25.3
OMIM
251450
3D Structure
ModBase 3D Structure for Q8WVQ1
Immunogen
Synthetic peptide selected from the N-terminal region of human CANT1 (KLH).

Product Categories/Family for anti-CANT1 antibody

Antibodies; Abs to Enzymes; Nucleotidase
Applications Tested/Suitable for anti-CANT1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-CANT1 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500

Western Blot (WB) of anti-CANT1 antibody

Western blot analysis of CANT1 Antibody (N-term) in Jurkat, A375, Y79, WiDr cell line lysates (35ug/lane). CANT1 (arrow) was detected using the purified Pab.
Rabbit Anti-CANT1 Polyclonal Antibody – Cat# MBS630047

Flow Cytometry (FC/FACS) of anti-CANT1 antibody

CANT1 Antibody (N-term) flow cytometric analysis of Jurkat cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-CANT1 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS630047

Other Notes

Small volumes of anti-CANT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CANT1 purchase

MBS630047 is an antibody targeting CANT1. Also known as CANT1, NT (Putative NF-kappa-B-activating Protein 107, Putative MAPK-activating Protein PM09, Apyrase Homolog, Soluble Calcium-activated Nucleotidase 1, SCAN-1, SHAPY). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CANT1. It may not necessarily be applicable to this product.

NCBI GI #
40675592
NCBI GeneID
124583
UniProt Primary Accession #
Q8WVQ1
UniProt Secondary Accession #
Q7Z2J7; Q8NG05; Q8NHP0; Q9BSD5
UniProt Related Accession #
Q8WVQ1
NCBI Official Full Name
CANT1 protein
NCBI Official Synonym Full Names
calcium activated nucleotidase 1
NCBI Official Symbol
CANT1
NCBI Official Synonym Symbols
DBQD; SCAN1; SHAPY; SCAN-1
UniProt Protein Name
Soluble calcium-activated nucleotidase 1
UniProt Synonym Protein Names
Apyrase homolog; Putative MAPK-activating protein PM09; Putative NF-kappa-B-activating protein 107
Protein Family
Soluble calcium-activated nucleotidase
UniProt Gene Name
CANT1
UniProt Synonym Gene Names
SHAPY
UniProt Entry Name
CANT1_HUMAN
NCBI Protein Information
soluble calcium-activated nucleotidase 1; apyrase homolog; putative MAPK-activating protein PM09; putative NF-kappa-B-activating protein 107; soluble Ca-activated nucleotidase, isozyme 1; soluble calcium-activated nucleotidase SCAN-1; Ca2+-dependent endoplasmic reticulum nucleoside diphosphatase; micromelic dwarfism with vertebral and metaphyseal abnormalities and advanced carpotarsal ossification

NCBI Summary for CANT1

This protein encoded by this gene belongs to the apyrase family. It functions as a calcium-dependent nucleotidase with a preference for UDP. Mutations in this gene are associated with Desbuquois dysplasia with hand anomalies. Alternatively spliced transcript variants have been noted for this gene.

UniProt Comments for CANT1

CANT1: Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis. Defects in CANT1 are the cause of Desbuquois dysplasia (DBQD). A chondrodysplasia characterized by severe prenatal and postnatal growth retardation (less than -5 SD), joint laxity, short extremities, progressive scoliosis, round face, midface hypoplasia, prominent bulging eyes. The main radiologic features are short long bones with metaphyseal splay, a 'Swedish key' appearance of the proximal femur (exaggerated trochanter), and advance carpal and tarsal bone age. Two forms of Desbuquois dysplasia are distinguished on the basis of the presence (type 1) or absence (type 2) of characteristic hand anomalies: an extra ossification center distal to the second metacarpal, delta phalanx, bifid distal thumb phalanx, and phalangeal dislocations. Belongs to the apyrase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleotide Metabolism - pyrimidine; Endoplasmic reticulum; Nucleotide Metabolism - purine; EC 3.6.1.6; Hydrolase; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: endoplasmic reticulum membrane; integral to membrane

Molecular Function: signal transducer activity; calcium ion binding; uridine-diphosphatase activity

Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; proteoglycan biosynthetic process; signal transduction

Disease: Desbuquois Dysplasia 1
Show more

Research Articles on CANT1

1. CANT1 is commonly overexpressed in the vast majority of primary prostate carcinomas and in the precursor lesion PIN and may represent a novel prognostic biomarker

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CANT1 antibody

 Products by Pathway  Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram

Diseases associated with anti-CANT1 antibody

 Disease Name  Pubmed Publications
 Prostatic Neoplasms Antibodies  >3 publications with CANT1 and Prostatic Neoplasms
 Bone Diseases, Developmental Antibodies  >2 publications with CANT1 and Bone Diseases, Developmental
 Congenital Abnormalities Antibodies  >2 publications with CANT1 and Congenital Abnormalities
 Craniofacial Abnormalities Antibodies  >1 publications with CANT1 and Craniofacial Abnormalities
 Carcinoma Antibodies  >1 publications with CANT1 and Carcinoma
 Fetal Death Antibodies  >1 publications with CANT1 and Fetal Death
 Desbuquois syndrome Antibodies  >1 publications with CANT1 and Desbuquois syndrome

Organs/Tissues associated with anti-CANT1 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >3 publications with CANT1 and Bone
 Prostate Antibodies  >3 publications with CANT1 and Prostate
 Lung Antibodies  >1 publications with CANT1 and Lung
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