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DUSP14 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS630095

DUSP14 is involved in the inactivation of MAP kinases. This proein dephosphorylates ERK, JNK and p38 MAP-kinases. In addition to antigen recognition by the T-cell receptor, T-cell activation requires a second signal from a costimulatory receptor, such as… More details

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Product Overview

Online Datasheet in PDF
Product Name
DUSP14, Polyclonal Antibody
Full Product Name
DUSP14, CT (Dual Specificity Protein Phosphatase 14, Mitogen-activated Protein Kinase Phosphatase 6, MAP Kinase Phosphatase 6, MKP6, MKP-6, MKP-1-like Protein Tyrosine Phosphatase, MKP-L)
Product Gene Name
anti-DUSP14 antibody
Product Synonym Names
Anti -DUSP14, CT (Dual Specificity Protein Phosphatase 14, Mitogen-activated Protein Kinase Phosphatase 6, MAP Kinase Phosphatase 6, MKP6, MKP-6, MKP-1-like Protein Tyrosine Phosphatase, MKP-L)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human DUSP14. Species Crossreactivity: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
22,255 Da
Chromosome Location
Chromosome: 17; NC_000017.10 (35849951..35873588). Location: 17q12
OMIM
606618
3D Structure
ModBase 3D Structure for O95147
Immunogen
Synthetic peptide selected from the C-terminal region of human DUSP14 (KLH).

Product Categories/Family for anti-DUSP14 antibody

Antibodies; Abs to Enzymes; Phosphatase
Applications Tested/Suitable for anti-DUSP14 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-DUSP14 antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100

Immunohistochemistry (IHC) of anti-DUSP14 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Rabbit Anti-DUSP14 Polyclonal Antibody – Cat# MBS630095

Western Blot (WB) of anti-DUSP14 antibody

Western blot analysis of anti-DUSP14 Pab in mouse kidney tissue lysate (35ug/lane). DUSP14(arrow) was detected using the purified Pab.
Rabbit Anti-DUSP14 Polyclonal Antibody, Western Blot (WB) – Cat# MBS630095

Western Blot (WB) of anti-DUSP14 antibody

Western blot analysis of DUSP14 (arrow) using rabbit polyclonal DUSP14 Antibody (D183) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the DUSP14 gene.
Rabbit Anti-DUSP14 Polyclonal Antibody, Western Blot (WB) – Cat# MBS630095

Other Notes

Small volumes of anti-DUSP14 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DUSP14 purchase

MBS630095 is an antibody targeting DUSP14. Also known as DUSP14, CT (Dual Specificity Protein Phosphatase 14, Mitogen-activated Protein Kinase Phosphatase 6, MAP Kinase Phosphatase 6, MKP6, MKP-6, MKP-1-like Protein Tyrosine Phosphatase, MKP-L). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DUSP14. It may not necessarily be applicable to this product.

NCBI GI #
5902002
NCBI GeneID
11072
NCBI Accession #
NP_008957.1
UniProt Primary Accession #
O95147
UniProt Related Accession #
O95147; Q6FI36
GenBank Nucleotide #
NM_007026.2
NCBI Official Full Name
dual specificity protein phosphatase 14
NCBI Official Synonym Full Names
dual specificity phosphatase 14
NCBI Official Symbol
DUSP14
NCBI Official Synonym Symbols
MKP6; MKP-L
UniProt Protein Name
Dual specificity protein phosphatase 14
UniProt Synonym Protein Names
MKP-1-like protein tyrosine phosphatase; MKP-L; Mitogen-activated protein kinase phosphatase 6
Protein Family
Dual specificity protein phosphatase
UniProt Gene Name
DUSP14
UniProt Synonym Gene Names
MKP6
UniProt Entry Name
DUS14_HUMAN
NCBI Protein Information
dual specificity protein phosphatase 14; MKP-6; OTTHUMP00000164064; MAP kinase phosphatase 6; MKP-1 like protein tyrosine phosphatase; MKP-1-like protein tyrosine phosphatase; mitogen-activated protein kinase phosphatase 6

NCBI Summary for DUSP14

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM]
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UniProt Comments for DUSP14

MKP-6: a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (ERK, JNK, p38). Is a negative regulator of T cell costimulation via CD28.

Protein type: Motility/polarity/chemotaxis; EC 3.1.3.16; Protein phosphatase, dual-specificity; EC 3.1.3.48

Chromosomal Location of Human Ortholog: 17q12

Molecular Function: protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity

Biological Process: inactivation of MAPK activity
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Research Articles on DUSP14

1. The overproduction, purification and crystal structure at 1.88 A resolution of human dual-specificity phosphatase 14, DUSP14 (MKP6), are reported.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DUSP14 antibody

 Reference Product  PubMed Publications
 CD28 antibody  >1 publications with DUSP14 and CD28

Pathways associated with anti-DUSP14 antibody

 Products by Pathway  Pathway Diagram
 Hypertrophy Model Pathway antibodies  Hypertrophy Model Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram

Diseases associated with anti-DUSP14 antibody

 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >1 publications with DUSP14 and Liver Diseases

Organs/Tissues associated with anti-DUSP14 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2 publications with DUSP14 and Blood
 Brain Antibodies  >2 publications with DUSP14 and Brain
 Lymph Node Antibodies  >1 publications with DUSP14 and Lymph Node
 Heart Antibodies  >1 publications with DUSP14 and Heart
 Pancreas Antibodies  >1 publications with DUSP14 and Pancreas
 Liver Antibodies  >1 publications with DUSP14 and Liver
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