PAK1 Antibody – Rabbit Polyclonal

The PAKs are a highly conserved family of serine-threonine protein kinases that bind to and are autophosphorylated and activated by small GTPases. Alpha-PAK (PAK-1) and beta-PAK (PAK-3) are mostly expressed in the brain while gamma-PAK (PAK-2) is expressed ubiquitously. In mammals, PAKs regulate the MAPK pathways and cytoskeletal organisation by increasing actin and tubulin polymerisation. PAKs also phosphorylate steroid receptors such as the estrogen and progesterone receptors. In humans the loss of function of PAK-3 is associated with X-linked, nonsyndromic mental retardation. Various phosphorylation sites exist on the PAKs, phosphorylation of Thr402 is essential for kinase activity. It should be noted that Thr402 in PAK-2 corresponds to Thr423 in PAK-1.

Small volumes of anti-PAK1/2/3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS630105 is an antibody targeting PAK1/2/3. Also known as PAK1/2/3, phosphorylated (Thr423/Thr402/Thr421) (p21 Activated Kinase 1,2,3). Reactive in Human, Mouse, Rat. Host: Rabbit.