Rabbit Anti-GCNT2 Polyclonal Antibody – Cat# MBS6301689

GCNT2 Antibody (Center) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the GCNT2 Antibody detected the GCNT2 protein (arrow).

GCNT2 Antibody – Rabbit Polyclonal

Name: GCNT2 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6301689
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6301689

This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a… More details

$1060 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GCNT2, Polyclonal Antibody

Full Product Name

GCNT2, ID (GCNT2, GCNT5, II, NACGT1, N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform A, I-branching enzyme, IGNT) (Biotin)

Product Gene Name

anti-GCNT2 antibody

Product Synonym Names

GCNT2; GCNT5; II; NACGT1; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase; isoform A; I-branching enzyme; IGNT

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

45,873 Da

OMIM

110800

3D Structure

ModBase 3D Structure for Q8N0V5

Immunogen

GCNT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 212-240 amino acids from the Central region of human GCNT2.

Conjugate

Biotin

Note

Preservative Free

Product Categories/Family for anti-GCNT2 antibody

Antibodies; Enzymes; Glycosyltransferase

Applications Tested/Suitable for anti-GCNT2 antibody

Western Blot (WB), ELISA (EIA)

Application Notes for anti-GCNT2 antibody

WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-GCNT2 antibody

Twu, Y.C., et al. Blood 110(13):4526-4534(2007). Wang, L., et al. Biochem. Biophys. Res. Commun. 331(4):958-963(2005). Pras, E., et al. Invest. Ophthalmol. Vis. Sci. 45(6):1940-1945(2004). Inaba, N., et al. Blood 101(7):2870-2876(2003). Yu, L.C., et al. Blood 101(6):2081-2088(2003).

Other Notes

Small volumes of anti-GCNT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GCNT2 purchase

MBS6301689 is an antibody targeting GCNT2. Also known as GCNT2, ID (GCNT2, GCNT5, II, NACGT1, N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform A, I-branching enzyme, IGNT) (Biotin). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GCNT2. It may not necessarily be applicable to this product.

NCBI GI #

21717810

NCBI GeneID

2651

NCBI Accession #

NP_663624.1

UniProt Primary Accession #

Q8N0V5

UniProt Related Accession #

Q06430; Q8N0V5; Q8NFS9

GenBank Nucleotide #

NM_145649.4

NCBI Official Full Name

N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase isoform A

NCBI Official Synonym Full Names

glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)

NCBI Official Symbol

GCNT2

NCBI Official Synonym Symbols

II; CCAT; IGNT; ULG3; GCNT5; GCNT2C; NACGT1; NAGCT1; CTRCT13; bA421M1.1; bA360O19.2

UniProt Protein Name

N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform A

UniProt Synonym Protein Names

I-branching enzyme; IGNT

Protein Family

N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase

UniProt Gene Name

GCNT2

UniProt Synonym Gene Names

GCNT5; II; NACGT1; N-acetylglucosaminyltransferase

UniProt Entry Name

GNT2A_HUMAN

NCBI Protein Information

N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase

UniProt Comments for GCNT2

GCNT2A: Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells. The expression of the blood group I antigen in erythrocytes is determined by isoform C. Belongs to the glycosyltransferase 14 family. 3 isoforms of the human protein are produced by alternative splicing

Protein type: EC 2.4.1.150

Chromosomal Location of Human Ortholog: 6p24.2

Cellular Component: Golgi membrane; membrane; integral to membrane

Molecular Function: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity

Biological Process: glycosaminoglycan biosynthetic process; positive regulation of protein kinase B signaling cascade; positive regulation of heterotypic cell-cell adhesion; multicellular organismal development; transforming growth factor beta receptor signaling pathway; positive regulation of cell proliferation; protein amino acid glycosylation; positive regulation of cell migration

Disease: Blood Group, I System

Research Articles on GCNT2

1. Hypomethylation of the GCNT2 variant 2 reflected lymph node metastasis of colorectal cancer in the tumor and normal tissues.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-GCNT2 antibody

Products by Pathway	Pathway Diagram
Glycosphingolipid Biosynthesis - Lacto And Neolacto Series Pathway antibodies	Glycosphingolipid Biosynthesis - Lacto And Neolacto Series Pathway Diagram
Glycosphingolipid Biosynthesis - Lacto And Neolacto Series Pathway antibodies	Glycosphingolipid Biosynthesis - Lacto And Neolacto Series Pathway Diagram
Metabolic Pathways antibodies	Metabolic Pathways Diagram
Terminal O-glycans Residues Modification Pathway antibodies	Terminal O-glycans Residues Modification Pathway Diagram
Terminal O-glycans Residues Modification Pathway antibodies	Terminal O-glycans Residues Modification Pathway Diagram

Diseases associated with anti-GCNT2 antibody

Disease Name	Pubmed Publications
CATARACT, CONGENITAL OR JUVENILE Antibodies	>67898 publications with GCNT2 and CATARACT, CONGENITAL OR JUVENILE
Lung Diseases Antibodies	>1 publications with GCNT2 and Lung Diseases
Death Antibodies	>1 publications with GCNT2 and Death
Breast Neoplasms Antibodies	>1 publications with GCNT2 and Breast Neoplasms
Neoplasms, Experimental Antibodies	>1 publications with GCNT2 and Neoplasms, Experimental
Lung Neoplasms Antibodies	>1 publications with GCNT2 and Lung Neoplasms

Organs/Tissues associated with anti-GCNT2 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>4 publications with GCNT2 and Blood
Embryonic Tissue Antibodies	>2 publications with GCNT2 and Embryonic Tissue
Pancreas Antibodies	>1 publications with GCNT2 and Pancreas
Liver Antibodies	>1 publications with GCNT2 and Liver
Lung Antibodies	>1 publications with GCNT2 and Lung
Muscle Antibodies	>1 publications with GCNT2 and Muscle
Prostate Antibodies	>1 publications with GCNT2 and Prostate
Lymph Node Antibodies	>1 publications with GCNT2 and Lymph Node